Perioperative radiotherapy versus surgery alone for retroperitoneal sarcomas: a systematic review and meta-analysis
Article Category: Review
Published Online: Feb 29, 2020
Page range: 14 - 21
Received: Dec 26, 2020
Accepted: Jan 31, 2020
DOI: https://doi.org/10.2478/raon-2020-0012
© 2020 Alexandros Diamantis, Ioannis Baloyiannis, Dimitrios E. Magouliotis, Maria Tolia, Dimitrios Symeonidis, Effrosyni Bompou, Georgios Polymeneas, Konstantinos Tepetes, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Background
There is no clear evidence on whether radiotherapy (RT) improves treatment result in patients with retroperitoneal sarcomas (RPS).
Methods
A systematic literature search was performed using PubMed, Scopus and CENTRAL databases. Data were retrieved from published comparatives studies in patients with RPS undergoing surgery alone or RT plus surgery. The primary endpoints were the 5-year OS and the median OS. The secondary endpoints were the recurrence-free survival (RFS) and the R0-resection rate. Continuous outcomes were calculated by means of weighted mean difference (WMD).
Results
Ten out of 374 articles were analyzed. The median OS and the 5-year survival were significantly increased in patients treated with RT and surgery, compared to patients treated with surgery alone (
Conclusion
RT along with radical surgery could be the standard of care in at least a subgroup of patients with RPS.