<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2020-0012_s_006_w2aab3b8c22b1b7b1aab1c16b1Aa"><h3>Background</h3><p>There is no clear evidence on whether radiotherapy (RT) improves treatment result in patients with retroperitoneal sarcomas (RPS).</p></sec><sec id="j_raon-2020-0012_s_007_w2aab3b8c22b1b7b1aab1c16b2Aa"><h3>Methods</h3><p>A systematic literature search was performed using PubMed, Scopus and CENTRAL databases. Data were retrieved from published comparatives studies in patients with RPS undergoing surgery alone or RT plus surgery. The primary endpoints were the 5-year OS and the median OS. The secondary endpoints were the recurrence-free survival (RFS) and the R0-resection rate. Continuous outcomes were calculated by means of weighted mean difference (WMD).</p></sec><sec id="j_raon-2020-0012_s_008_w2aab3b8c22b1b7b1aab1c16b3Aa"><h3>Results</h3><p>Ten out of 374 articles were analyzed. The median OS and the 5-year survival were significantly increased in patients treated with RT and surgery, compared to patients treated with surgery alone (<italic>p</italic> &lt; 0.00001, <italic>p</italic> &lt; 0.001). Median RFS was significantly increased in patients treated with either preoperative (<italic>p</italic> &lt; 0.001) or postoperative (<italic>p</italic> = 0.001) RT compared to patients that underwent surgery alone. Finally, median R0-resection rate was similar between the two groups (<italic>p</italic> = 0.56).</p></sec><sec id="j_raon-2020-0012_s_009_w2aab3b8c22b1b7b1aab1c16b4Aa"><h3>Conclusion</h3><p>RT along with radical surgery could be the standard of care in at least a subgroup of patients with RPS.</p></sec></abstract>

BackgroundThere is no clear evidence on whether radiotherapy (RT) improves treatment result in patients with retroperitoneal sarcomas (RPS).MethodsA systematic literature search was performed using PubMed, Scopus and CENTRAL databases. Data were retrieved from published comparatives studies in patients with RPS undergoing surgery alone or RT plus surgery. The primary endpoints were the 5-year OS and the median OS. The secondary endpoints were the recurrence-free survival (RFS) and the R0-resection rate. Continuous outcomes were calculated by means of weighted mean difference (WMD).ResultsTen out of 374 articles were analyzed. The median OS and the 5-year survival were significantly increased in patients treated with RT and surgery, compared to patients treated with surgery alone (p < 0.00001, p < 0.001). Median RFS was significantly increased in patients treated with either preoperative (p < 0.001) or postoperative (p = 0.001) RT compared to patients that underwent surgery alone. Finally, median R0-resection rate was similar between the two groups (p = 0.56).ConclusionRT along with radical surgery could be the standard of care in at least a subgroup of patients with RPS.

Perioperative radiotherapy versus surgery alone for retroperitoneal sarcomas: a systematic review and meta-analysis

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundThere is no clear evidence on whether radiotherapy (RT) improves treatment result in patients with retroperitoneal sarcomas (RPS).MethodsA systematic...

Perioperative radiotherapy versus surgery alone for retroperitoneal sarcomas: a systematic review and meta-analysis

Article Category: Review

Published Online: Feb 29, 2020

Page range: 14 - 21

Received: Dec 26, 2020

Accepted: Jan 31, 2020

DOI: https://doi.org/10.2478/raon-2020-0012

© 2020 Alexandros Diamantis, Ioannis Baloyiannis, Dimitrios E. Magouliotis, Maria Tolia, Dimitrios Symeonidis, Effrosyni Bompou, Georgios Polymeneas, Konstantinos Tepetes, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.