Perioperative radiotherapy versus surgery alone for retroperitoneal sarcomas: a systematic review and meta-analysis
, , , , , , and | Feb 29, 2020
About this article
Article Category: Review
Published Online: Feb 29, 2020
Page range: 14 - 21
Received: Dec 26, 2020
Accepted: Jan 31, 2020
DOI: https://doi.org/10.2478/raon-2020-0012
© 2020 Alexandros Diamantis, Ioannis Baloyiannis, Dimitrios E. Magouliotis, Maria Tolia, Dimitrios Symeonidis, Effrosyni Bompou, Georgios Polymeneas, Konstantinos Tepetes, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
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Characteristics
| Study ID,Year | Journal | Country | Time Period | Type of Study | Patients, n | Female, n (%) | Median Age(Range) | Stars In Ottawa | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SA | RT+S | SA | RT+S | SA | RT+S | ||||||
| Ann Surg | USA | 2003-2011 | R | 172 | 321 | 84 (49%) | 17 (53%) | 62 (26-92 | 57 (41-85) | 6 | |
| J Surg Onc | USA | - | R | 45 | 29 | 23 (51,1%) | 16 (55,2%) | 60 (52, 68) | 57 (51, 61) | 5 | |
| Lancet Oncol | USA | 2003-2011 | R | 3322 | 5631 | 1713 (51,5%) | 250 (44%) | 59,5 (± 14,5) | 59,2 (±13,8), | 6 | |
| EJSO | USA | 1973-1998 | P | 21 | 412 | N/A | N/A | N/A | N/A | 5 | |
| Radiother Oncol | Canada | 1996-2000 | R | 104 | 401 | 49 (47%) | 25 (62%) | N/A | N/A | 6 | |
| Cancer | France | 1980-1994 | R | 55 | 892 | N/A | N/A | N/A | N/A | 5 | |
| J Surg Onc | USA | 1996-2011 | R | 26 | 371 | 9 (35%) | 17 (46%) | 74 | 56 | 6 | |
| Annals of Oncology | France | 1988-2008 | R | 262 | 127 | - | - | - | - | 5 | |
| Acta Oncologica | Sweden | 1988-2009 | R | 55 | 42 | 22 (58,2%) | 15 (33%) | 63(15-83) | 61(35-82) | 6 | |
| Arch Surg | USA | 1988-2005 | R | 1175 | 3722 | - | - | - | - | 5 | |
Summary of the analysis of the categorical and continuous outcomes
| Categorical Outcomes | n | OR (95% CI)* | Heterogeneity | ||
|---|---|---|---|---|---|
| 9 | 0.69 [0.62, 0.77] | <0.0001 | 67 % | 0.002 | |
| 5 | 0.69 [0.56, 0.85] | 0.0005 | 50 % | 0.09 | |
| 4 | 0.69 [0.61, 0.79] | <0.0001 | 82 % | 0.001 | |
| 6 | 0.33 [0.24, 0.46] | <0.0001 | 69 % | 0.006 | |
| 4 | 0.19 [0.11, 0.33] | <0.0001 | 72 % | 0.001 | |
| 2 | 0.49 [0.32, 0.75] | 0.001 | 0 % | 0.81 | |
| 3 | 0.90 [0.81, 0.99] | 0.03 | 69 % | 0.04 | |
| 2 | 1.21 [0.65, 2.25] | 0.56 | 82 % | 0.02 | |
| 1 | 0.89 [0.81, 0.98] | 0.02 | N/A | - | |
| 5 | -18.94 [-19.14, -18.74] | <0.0001 | 100 % | < 0.0001 | |
| 2 | -22.93 [-27.91, -17.96] | <0.0001 | 30 % | 0.23 | |
| 3 | -18.93 [-19.13, -18.74] | <0.0001 | 100 % | < 0.0001- | |