This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Darby SC, Kan SW, Spooner RJ, et al Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV. Blood 2007; 110: 815–25. doi: 10.1182/ blood-2006-10-050435.DarbySCKanSWSpoonerRJet alMortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIVBlood20071108152510.1182/blood-2006-10-05043517446349Open DOISearch in Google Scholar
von Drygalski A, Kolaitis NA, Bettencourt R, et al Prevalence and risk factors for hypertension in hemophilia. Hypertension 2013; 62: 209–15. doi: 10.1161/ HYPERTENSIONAHA.113.01174.von DrygalskiAKolaitisNABettencourtRet alPrevalence and risk factors for hypertension in hemophiliaHypertension2013622091510.1161/HYPERTENSIONAHA.113.01174385077523630949Open DOISearch in Google Scholar
Fransen van de Putte DE, Fischer K, Makris M, et al Increased prevalence of hypertension in haemophilia patients. Thromb Haemost 2012; 108: 750–5. doi: 10.1160/TH12-05-0313.Fransen van de PutteDEFischerKMakrisMet alIncreased prevalence of hypertension in haemophilia patientsThromb Haemost2012108750510.1160/TH12-05-031322955860Open DOISearch in Google Scholar
Minuk L, Jackson S, Iorio A, et al Cardiovascular disease (CVD) in Canadians with haemophilia: Age-Related CVD in Haemophilia Epidemiological Research (ARCHER study). Haemophilia 2015; 21: 736–41. doi: 10.1111/hae.12768.MinukLJacksonSIorioAet alCardiovascular disease (CVD) in Canadians with haemophilia: Age-Related CVD in Haemophilia Epidemiological Research (ARCHER study)Haemophilia2015217364110.1111/hae.1276826222883Open DOISearch in Google Scholar
Ariesen MJ, Claus SP, Rinkel GJ, Algra A. Risk factors for intracerebral hemorrhage in the general population: a systematic review. Stroke 2003; 34: 2060–5. doi: 10.1161/01. STR.0000080678.09344.8D.AriesenMJClausSPRinkelGJAlgraARisk factors for intracerebral hemorrhage in the general population: a systematic reviewStroke2003342060510.1161/01.STR.0000080678.09344.8D12843354Open DOISearch in Google Scholar
Stieltjes N, Calvez T, Demiguel V, et al French ICH Study Group. Intracranial haemorrhages in French haemophilia patients (1991-2001): clinical presentation, management and prognosis factors for death. Haemophilia 2005; 11: 452–8. doi: 10.1111/j.1365-2516.2005.01090.x.StieltjesNCalvezTDemiguelVet alFrench ICH Study Group. Intracranial haemorrhages in French haemophilia patients (1991-2001): clinical presentation, management and prognosis factors for deathHaemophilia200511452810.1111/j.1365-2516.2005.01090.x16128887Open DOISearch in Google Scholar
Barnes RF, Cramer TJ, Sait AS, Kruse-Jarres R, Quon DV, von Drygalski A. The hypertension of hemophilia is not explained by the usual cardiovascular risk factors: results of a cohort study. Int J Hypertens 2016; 2016: 2014201. doi: 10.1155/2016/2014201.BarnesRFCramerTJSaitASKruse-JarresRQuonDVvon DrygalskiAThe hypertension of hemophilia is not explained by the usual cardiovascular risk factors: results of a cohort studyInt J Hypertens20162016201420110.1155/2016/2014201512466227965893Open DOISearch in Google Scholar
Sait AS, Kuo A, Bettencourt R, Bergstrom J, Allison M, von Drygalski A. Risk assessment for coronary heart disease in patients with haemophilia: a single centre study in the United States. Haemophilia 2014; 20: 763–70. doi: 10.1111/hae.12472.SaitASKuoABettencourtRBergstromJAllisonMvon DrygalskiARisk assessment for coronary heart disease in patients with haemophilia: a single centre study in the United StatesHaemophilia2014207637010.1111/hae.1247224893625Open DOISearch in Google Scholar
Sun HL, Yang M, Sait AS, von Drygalski A, Jackson S. Haematuria is not a risk factor of hypertension or renal impairment in patients with haemophilia. Haemophilia 2016; 22: 549–55. doi: 10.1111/hae.12921.SunHLYangMSaitASvon DrygalskiAJacksonSHaematuria is not a risk factor of hypertension or renal impairment in patients with haemophiliaHaemophilia2016225495510.1111/hae.1292127030081Open DOISearch in Google Scholar
Bhat V, Olmer M, Joshi S, et al Vascular remodeling underlies rebleeding in hemophilic arthropathy. Am J Hematol 2015; 90: 1027–35. doi: 10.1002/ajh.24133.BhatVOlmerMJoshiSet alVascular remodeling underlies rebleeding in hemophilic arthropathyAm J Hematol20159010273510.1002/ajh.24133461806726257191Open DOISearch in Google Scholar
Barnes RFW, Cramer TJ, Hughes TH, von Drygalski A. The hypertension of hemophilia is associated with vascular remodeling in the joint. Microcirculation 2017; 24. doi: 10.1111/ micc.12387.BarnesRFWCramerTJHughesTHvon DrygalskiAThe hypertension of hemophilia is associated with vascular remodeling in the jointMicrocirculation20172410.1111/micc.1238728627086Open DOISearch in Google Scholar
Pickering TG, Hall JE, Appel LJ, et al Recommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Circulation 2005; 111: 697–716. doi: 10.1161/01. CIR.0000154900.76284.F6.PickeringTGHallJEAppelLJet alRecommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure ResearchCirculation200511169771610.1161/01.CIR.0000154900.76284.F615699287Open DOISearch in Google Scholar
Koenker R. Quantile regression. 2005. New York: Cambridge University Press.KoenkerRQuantile regression2005New YorkCambridge University Press10.1017/CBO9780511754098Search in Google Scholar
Hao L, Naiman D. Quantile regression. 2007. Thousand Oaks, CA: Sage Publications.HaoLNaimanDQuantile regression2007Thousand Oaks, CASage Publications10.4135/9781412985550Search in Google Scholar
SAS. SAS/STAT 9.22 User's Guide. 2010. Cary, NC: SAS Institute Inc. Available from https://support.sas.com/documentation/cdl/en/statug/63347/HTML/default/viewer.htm (accessed 26 August 2019).SAS. SAS/STAT 9.22User's Guide2010Cary, NCSAS Institute IncAvailable fromhttps://support.sas.com/documentation/cdl/en/statug/63347/HTML/default/viewer.htmaccessed 26 August 2019Search in Google Scholar
Statcompute. SAS macro calculating goodness-of-fit statistics for quantile regression. 15 April 2017. Available from https://statcompute.wordpress.com/2017/04/15/sas-macro-calculating-goodness-of-fit-statistics-for-quantile-regression/ (accessed 29 August 2019).Statcompute. SAS macro calculating goodness-of-fit statistics for quantile regression. 15 April2017Available fromhttps://statcompute.wordpress.com/2017/04/15/sas-macro-calculating-goodness-of-fit-statistics-for-quantile-regression/accessed 29 August 2019Search in Google Scholar
Koenker R, Machado J. Goodness of fit and related inference processes for quantile regression. J Am Stat Assoc 1999; 94: 1296–310.KoenkerRMachadoJGoodness of fit and related inference processes for quantile regressionJ Am Stat Assoc199994129631010.1080/01621459.1999.10473882Search in Google Scholar
Whelton PK, Carey RM, Aronow WS, et al 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 2018; 138: e426-e83. doi: 10.1161/CIR.0000000000000597.WheltonPKCareyRMAronowWSet al2017ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice GuidelinesCirculation2018138e426e8310.1161/CIR.000000000000059730354655Open DOISearch in Google Scholar
Schroeder V, Kohler HP. New developments in the area of factor XIII. J Thromb Haemost 2013; 11: 234–44. doi: 10.1111/ jth.12074.SchroederVKohlerHPNew developments in the area of factor XIIIJ Thromb Haemost2013112344410.1111/jth.1207423279671Open DOISearch in Google Scholar
Bouma BN, Mosnier LO. Thrombin activatable fibrinolysis inhibitor (TAFI) – how does thrombin regulate fibrinolysis? Ann Med 2006; 38: 378–88. doi: 10.1080/07853890600852898.BoumaBNMosnierLOThrombin activatable fibrinolysis inhibitor (TAFI) – how does thrombin regulate fibrinolysis?Ann Med2006383788810.1080/0785389060085289817008302Open DOISearch in Google Scholar
Poli KA, Tofler GH, Larson MG, et al Association of blood pressure with fibrinolytic potential in the Framingham offspring population. Circulation 2000; 101: 264–9. doi: 10.1161/01.CIR.101.3.264.PoliKAToflerGHLarsonMGet alAssociation of blood pressure with fibrinolytic potential in the Framingham offspring populationCirculation2000101264910.1161/01.CIR.101.3.26410645922Open DOISearch in Google Scholar
Sane DC, Kontos JL, Greenberg CS. Roles of transglutaminases in cardiac and vascular diseases. Front Biosci. 2007; 12: 2530-45.SaneDCKontosJLGreenbergCSRoles of transglutaminases in cardiac and vascular diseasesFront Biosci20071225304510.2741/2253276254917127261Search in Google Scholar
Loof TG, Mörgelin M, Johansson L, et al Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense. Blood 2011; 118: 2589–98. doi: 10.1182/blood-2011-02-337568.LoofTGMörgelinMJohanssonLet alCoagulation, an ancestral serine protease cascade, exerts a novel function in early immune defenseBlood201111825899810.1182/blood-2011-02-337568Open DOISearch in Google Scholar
Mian MO, Paradis P, Schiffrin EL. Innate immunity in hypertension. Curr Hypertens Rep 2014; 16: 413. doi: 10.1007/ s11906-013-0413-9.MianMOParadisPSchiffrinELInnate immunity in hypertensionCurr Hypertens Rep20141641310.1007/s11906-013-0413-9Open DOISearch in Google Scholar
Myles T, Nishimura T, Yun TH, et al Thrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation. J Biol Chem 2003; 278: 51059–67. doi: 10.1074/ jbc.M306977200.MylesTNishimuraTYunTHet alThrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammationJ Biol Chem2003278510596710.1074/jbc.M306977200Open DOISearch in Google Scholar
Mosnier LO, Lisman T, van den Berg HM, et al The defective down regulation of fibrinolysis in haemophilia A can be restored by increasing the TAFI plasma concentration. Thromb Haemost 2001; 86: 1035–9.MosnierLOLismanTvan den BergHMet alThe defective down regulation of fibrinolysis in haemophilia A can be restored by increasing the TAFI plasma concentrationThromb Haemost2001861035910.1055/s-0037-1616530Search in Google Scholar
Wyseure T, Cooke EJ, Declerck PJ, et al Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding. Blood 2018; 132: 1593–603. doi: 10.1182/ blood-2018-01-828434.WyseureTCookeEJDeclerckPJet alDefective TAFI activation in hemophilia A mice is a major contributor to joint bleedingBlood2018132159360310.1182/blood-2018-01-828434Open DOISearch in Google Scholar
Sharma JN. Hypertension and the bradykinin system. Curr Hypertens Rep 2009; 11: 178–81.SharmaJNHypertension and the bradykinin systemCurr Hypertens Rep2009111788110.1007/s11906-009-0032-7Search in Google Scholar
Urano T, Ihara H, Suzuki Y, Takada Y, Takada A. Coagulation-associated enhancement of fibrinolytic activity via a neutralization of PAI-1 activity. Semin Thromb Hemost 2000; 26: 39–42.UranoTIharaHSuzukiYTakadaYTakadaACoagulation-associated enhancement of fibrinolytic activity via a neutralization of PAI-1 activitySemin Thromb Hemost200026394210.1055/s-2000-9801Search in Google Scholar
Levi M, Keller TT, van Gorp E, ten Cate H. Infection and inflammation and the coagulation system. Cardiovasc Res 2003; 60: 26–39.LeviMKellerTTvan GorpEten CateHInfection and inflammation and the coagulation systemCardiovasc Res200360263910.1016/S0008-6363(02)00857-XSearch in Google Scholar
Fahs SA, Hille MT, Shi Q, Weiler H, Montgomery RR. A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII. Blood 2014; 123: 3706–13. doi: 10.1182/ blood-2014-02-555151.FahsSAHilleMTShiQWeilerHMontgomeryRRA conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIIIBlood201412337061310.1182/blood-2014-02-555151405592124705491Open DOISearch in Google Scholar
Everett LA, Cleuren AC, Khoriaty RN, Ginsburg D. Murine coagulation factor VIII is synthesized in endothelial cells. Blood 2014; 123: 3697–705. doi: 10.1182/blood-2014-02-554501.EverettLACleurenACKhoriatyRNGinsburgDMurine coagulation factor VIII is synthesized in endothelial cellsBlood2014123369770510.1182/blood-2014-02-554501405592024719406Open DOISearch in Google Scholar
Sun H, Yang M, Fung M, et al Adult males with haemophilia have a different macrovascular and microvascular endothelial function profile compared with healthy controls. Haemophilia 2017; 23: 777–83. doi: 10.1111/hae.13278.SunHYangMFungMet alAdult males with haemophilia have a different macrovascular and microvascular endothelial function profile compared with healthy controlsHaemophilia2017237778310.1111/hae.1327828621454Open DOISearch in Google Scholar
Sartori MT, Bilora F, Zanon E, et al Endothelial dysfunction in haemophilia patients. Haemophilia 2008; 14: 1055–62. doi: 10.1111/j.1365-2516.2008.01808.x.SartoriMTBiloraFZanonEet alEndothelial dysfunction in haemophilia patientsHaemophilia20081410556210.1111/j.1365-2516.2008.01808.x18624700Open DOISearch in Google Scholar
Higashi Y, Kihara Y, Noma K. Endothelial dysfunction and hypertension in aging. Hypertens Res 2012; 35: 1039–47. doi: 10.1038/hr.2012.138.HigashiYKiharaYNomaKEndothelial dysfunction and hypertension in agingHypertens Res20123510394710.1038/hr.2012.13822972557Open DOISearch in Google Scholar
Srivastava A, Brewer AK, Mauser-Bunschoten EP, et al Hemophilia Treatment Guidelines Working Group on Behalf of the World Federation of Hemophilia. Guidelines for the management of hemophilia. Haemophilia 2013; 19: e1–47. doi: 10.1111/j.1365-2516.2012.02909.x.SrivastavaABrewerAKMauser-BunschotenEPet alHemophilia Treatment Guidelines Working Group on Behalf of the World Federation of Hemophilia. Guidelines for the management of hemophiliaHaemophilia201319e14710.1111/j.1365-2516.2012.02909.x22776238Open DOISearch in Google Scholar
Manco-Johnson MJ, Abshire TC, Shapiro AD, et al Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. N Engl J Med 2007; 357: 535–44. doi: 10.1056/NEJMoa067659.Manco-JohnsonMJAbshireTCShapiroADet alProphylaxis versus episodic treatment to prevent joint disease in boys with severe hemophiliaN Engl J Med20073575354410.1056/NEJMoa06765917687129Open DOISearch in Google Scholar
, 