Blood pressure in haemophilia and its relation to clotting factor usage
, , , , and | Dec 23, 2019
About this article
Article Category: Clinical Research
Published Online: Dec 23, 2019
Page range: 42 - 50
DOI: https://doi.org/10.17225/jhp00147
Keywords
© 2019 Srila Gopal, Richard FW Barnes, Doris V Quon, Hao Wei (Linda) Sun, Shannon Jackson, Annette von Drygalski, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1A
Figure 1B
Figure 1C
Figure 2A
Figure 2B
Figure 2C
Hypertension categories based on American Heart Association guidelines, 2017
| CATEGORY | BP RANGE (MM HG) | NUMBER | % |
|---|---|---|---|
| Normal | < 120/ 80 mm Hg | 54 | 28 |
| Elevated | SBP 12-129 mm Hg | 53 | 27 |
| Hypertension | SBP 130-139 or DBP | 58 | 30 |
| Hypertension | SBP > 139 mm Hg or | 28 | 15 |
3B. Regression coefficients for systolic blood pressure, adjusted for logBMI
| QUANTILE | REGRESSION COEFFICIENT X 10-3 | 95% CI X 10-3 | R1 | P |
|---|---|---|---|---|
| 0.1 Lower | -0.19 | -1.45, 0.70 | 0.236 | 0.634 |
| 0.5 Median | -0.05 | -0.89, 1.30 | 0.235 | 0.704 |
| 0.9 Upper | -0.29 | -3.05, 2.63 | 0.213 | 0.672 |
3C. Regression coefficients for diastolic blood pressure (unadjusted)
| QUANTILE | REGRESSION COEFFICIENT X 10-3 | 95% CI X 10-3 | R1 | P |
|---|---|---|---|---|
| 0.1 Lower | -0.65 | -1.26, -0.21 | 0.044 | 0.002 |
| 0.5 Median | 0.00 | -1.31, 0.70 | 0.000 | 0.523 |
| 0.9 Upper | -0.39 | -2.19, 1.29 | 0.009 | 0.596 |
Demographic characteristics of patients by factor use category
| MEDIAN (IQR) | COMPARISON OF PROPHYLAXIS | |||
|---|---|---|---|---|
| ALL PATIENTS | PROPHYLAXIS | ON DEMAND | AND ON-DEMAND PATIENTS, WILCOXON W (P) | |
| Age (years) | 30 (25, 41) | 30 (25, 38) | 37 (26, 49) | 4510 (0.010) |
| Systolic BP (mmHg) | 125 (118, 133) | 124 (118, 132) | 125 (115, 134) | 3706 (0.953) |
| Diastolic BP (mmHg) | 76 (71, 82) | 76 (71, 81) | 78 (71, 85) | 3950 (0.462) |
| BMI (kg/m2) | 24.5 (22.0, 27.8) | 24.5 (22.4, 27.8) | 24.4 (21.4, 28.7) | 2878 (0.995) |
| Factor usage | 3651 (1705, 5771) | 4179 (2889, 6551) | 818 (485, 1409) | 1341 (<0.001) |
Quantile regression for systolic and diastolic blood pressure on factor usage for patients on prophylaxisThe regression coefficients for the 0.1 (lower), 0.5 (median) and 0.9 (upper) quantiles are shown.3A. Regression coefficients for systolic blood pressure (unadjusted)
| QUANTILE | REGRESSION COEFFICIENT X 10-3 | 95% CI X 10-3 | R1 | P |
|---|---|---|---|---|
| 0.1 Lower | -0.29 | -1.68, 0.38 | 0.004 | 0.366 |
| 0.5 Median | -0.57 | -1.43, 0.13 | 0.012 | 0.146 |
| 0.9 Upper | -0.75 | -3.43, 0.75 | 0.001 | 0.378 |
3D. Regression coefficients for diastolic blood pressure, adjusted for logBMI and HCV
| QUANTILE | REGRESSION COEFFICIENT X 10-3 | 95% CI X 10-3 | R1 | P |
|---|---|---|---|---|
| 0.1 Lower | -0.67 | -1.33, -0.19 | 0.254 | 0.061 |
| 0.5 Median | -0.24 | -0.65, 0.51 | 0.261 | 0.914 |
| 0.9 Upper | -0.01 | -2.59, 2.18 | 0.266 | 0.698 |