<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_jhp00147_s_006_w2aab3b7c61b1b6b1aab1c14b1Aa"><h3>Background</h3><p>Patients with haemophilia have a higher prevalence of hypertension than the general population that cannot be explained by traditional cardiovascular risk factors such as age, race, diabetes or obesity. Patients with severe haemophilia, who are on clotting factor prophylaxis, have a higher prevalence of hypertension compared to patients with milder forms of haemophilia, who infuse clotting factor less frequently. This raises the question of whether there is a link between clotting factor usage and blood pressure in haemophilia patients.</p></sec><sec id="j_jhp00147_s_007_w2aab3b7c61b1b6b1aab1c14b2Aa"><h3>Methods</h3><p>Data was collected from 193 patients with severe haemophilia presenting to three haemophilia treatment centres in the United States and Canada, including age, body mass index (BMI), blood pressure (BP), Hepatitis C (HCV) and Human Immunodeficiency Virus (HIV) infection status, and clotting factor usage from pharmacy prescriptions (units/kg/year). The correlation between BP and factor usage was examined using quantile regression models.</p></sec><sec id="j_jhp00147_s_008_w2aab3b7c61b1b6b1aab1c14b3Aa"><h3>Results</h3><p>Systolic and diastolic BP plotted against factor use showed a cone-shaped scatter of points. There was no association between clotting factor usage and higher systolic or diastolic BP.</p></sec><sec id="j_jhp00147_s_009_w2aab3b7c61b1b6b1aab1c14b4Aa"><h3>Conclusion</h3><p>Our observations provide no evidence for an association between increased clotting factor usage and high BP.</p></sec></abstract>

BackgroundPatients with haemophilia have a higher prevalence of hypertension than the general population that cannot be explained by traditional cardiovascular risk factors such as age, race, diabetes or obesity. Patients with severe haemophilia, who are on clotting factor prophylaxis, have a higher prevalence of hypertension compared to patients with milder forms of haemophilia, who infuse clotting factor less frequently. This raises the question of whether there is a link between clotting factor usage and blood pressure in haemophilia patients.MethodsData was collected from 193 patients with severe haemophilia presenting to three haemophilia treatment centres in the United States and Canada, including age, body mass index (BMI), blood pressure (BP), Hepatitis C (HCV) and Human Immunodeficiency Virus (HIV) infection status, and clotting factor usage from pharmacy prescriptions (units/kg/year). The correlation between BP and factor usage was examined using quantile regression models.ResultsSystolic and diastolic BP plotted against factor use showed a cone-shaped scatter of points. There was no association between clotting factor usage and higher systolic or diastolic BP.ConclusionOur observations provide no evidence for an association between increased clotting factor usage and high BP.

Blood pressure in haemophilia and its relation to clotting factor usage

Hemostasis and Thrombosis, Department of Medicine

Hemophilia and Thrombosis Treatment Center, Department of Medicine

Orthopaedic Hemophilia Treatment Center, Orthopaedic Institute for Children

Division of Hematology, Department of Medicine

St. Paul’s Hospital and University of British Columbia

Department of Molecular Medicine, The Scripps Research Institute, Department of Molecular Medicine

The Journal of Haemophilia Practice

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Blood pressure in haemophilia and its relation to clotting factor usage"}

BackgroundPatients with haemophilia have a higher prevalence of hypertension than the general population that cannot be explained by traditional cardiovascular...

Blood pressure in haemophilia and its relation to clotting factor usage

Article Category: Clinical Research

Published Online: Dec 23, 2019

Page range: 42 - 50

DOI: https://doi.org/10.17225/jhp00147

Keywords
Haemophilia, hypertension, clotting factor use, blood pressure

© 2019 Srila Gopal, Richard FW Barnes, Doris V Quon, Hao Wei (Linda) Sun, Shannon Jackson, Annette von Drygalski, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Blood pressure in haemophilia and its relation to clotting factor usage

Article Category: Clinical Research

Published Online: Dec 23, 2019

Page range: 42 - 50

DOI: https://doi.org/10.17225/jhp00147

KeywordsHaemophilia, hypertension, clotting factor use, blood pressure

© 2019 Srila Gopal, Richard FW Barnes, Doris V Quon, Hao Wei (Linda) Sun, Shannon Jackson, Annette von Drygalski, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Haemophilia, hypertension, clotting factor use, blood pressure