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Early mobilization for mechanically ventilated patients in the intensive care unit: a systematic review and meta-analysis


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Figure 1

Flow diagram of process for identification of included studies.
Flow diagram of process for identification of included studies.

Figure 2

Forest plot for the effect of EM on duration of MV. Abbreviations: EM, early mobilization; MV, mechanical ventilation.
Forest plot for the effect of EM on duration of MV. Abbreviations: EM, early mobilization; MV, mechanical ventilation.

Figure 3

Subgroup analysis of the effect of EM on duration of MV according to standard intervention.
Abbreviations: EM, early mobilization; MV, mechanical ventilation.
Subgroup analysis of the effect of EM on duration of MV according to standard intervention. Abbreviations: EM, early mobilization; MV, mechanical ventilation.

Figure 4

Forest plot for the effect of EM on mortality rate. Abbreviation: EM, early mobilization.
Forest plot for the effect of EM on mortality rate. Abbreviation: EM, early mobilization.

Figure 5

Forest plot for the effect of EM on length of stay in ICU. Abbreviations: EM, early mobilization; ICU, intensive care unit.
Forest plot for the effect of EM on length of stay in ICU. Abbreviations: EM, early mobilization; ICU, intensive care unit.

Characteristics of included studies.

StudyDesignParticipantsInterventionOutcomes
Dong et al. 201420RCTExp: n=30 (male 70.0%); Age (y) =55.3 (16.1); APACHE II=15.0 (4.2) Con: n=30 (male 66%); Age (y)=55.5 (16.2); APACHE II=16.0 (4.1)Exp: EM Con: no mobilityDuration of MV Mortality ICULOS
Morris et al. 200821CCTExp: n=145 (male 56.4%); Age (y) =54.0 (16.8); APACHE II=23.5 (8.8) Con: n=135 (male 53.3%); Age (y) =55.4 (16.8); APACHE II=23.5 (8.8)Exp: EM Con: no mobilityMortality Duration of MV ICULOS Hospital LOS
Schweickert et al. 200922RCTExp: n=49 (male 41.0%); Age (y) =57.7 (36.3-69.1)*; APACHE II=20 (15.8-24)* Con: n=55 (male 58.0%); Age (y) =54.4 (46.5-66.4)*; APACHE II=19 (13.3-23)*Exp: EM Con: ordered by the primary care teamDuration of MV ICULOS
Patman et al. 200123RCTExp: n=101 (male 80.0 %); Age (y) =62.8 (12.2) Con: n=102 (male 71.0 %); Age (y) =63.3 (14.4)Exp: EM Con: physiotherapyDuration of MV ICULOS Hospital LOS
Caruso et al. 200524RCTExp: n=12 (male 67.0%); Age (y) =67 (10); APACHE II=23 (6) Con: n=13 (male 69.0%); Age (y) =66 (17); APACHE II=24 (7)Exp: EM Con: no inspiratory muscle trainingDuration of MV
Meesen et al. 201025RCTExp: n=7 (male 42.9%); Age (y) =63.5 (16.5) Con: n=12 (male 75.0%); Age (y) =67.2 (13.2)Exp: stimulated by an electro-stimulator Con: no stimulationThigh circumference Cardio-respiratory characteristics
Poulsen et al. 201126RCTExp: n=8 (male 100%); Age (y) =67 (64–72); APACHE II=25 (20-29) Con: patients served as own controlExp: stimulated by a battery-stimulator Con: no stimulationQuadriceps muscle volume
Rodriguez et al. 201227RCTExp: n=14 (male 50%); Age (y) =72 (63-80); APACHE II= 20 (18-27) Con: patients served as own controlCon: patients served as own control Con: no stimulationQuadriceps muscle strength Limb circumference Biceps thickness

PEDro scores for included studies.

StudyRandom allocationConcealed allocationGroups similar at baselineParticipant blindingTherapist blindingAssessor blinding<15% dropoutsIntention to-treat analysisBetween- group difference reportedPoint and variability reported
Dong et al. 201420YNYNNNYNYY
Morris et al. 200821NNYNNNYYYY
Schweickert et al. 200922YYYNNYNYYY
Patman et al. 200123YNYNNNNYYY
Caruso et al. 200524YNYNYNYNYY
Meesen et al. 201025YNYNNNYNYY
Poulsen et al. 201126YNYNNNYNYY
Rodriguez al. 201227 etYYYNNNYNYY
eISSN:
2544-8994
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Assistive Professions, Nursing