<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_fon-2018-0039_s_006_w2aab3b7b7b1b6b1aab1c17b1Aa"><h3>Background</h3><p>Early mobilization (EM) is a regimen that was carried out by physiotherapists in a relatively early stage. It has been investigated by an increasing number of researchers. However, there has not been a meta-analysis concerning whether EM could benefit the clinical outcomes of critically ill patients requiring mechanical ventilation (MV). The present systematic review aims to evaluate the effect of EM compared with immobilization for mechanically ventilated patients.</p></sec><sec id="j_fon-2018-0039_s_007_w2aab3b7b7b1b6b1aab1c17b2Aa"><h3>Methods</h3><p>A computerized literature search was performed in six databases for related articles from inception to June 2017. We included randomized controlled trials and controlled clinical trials and used the Physiotherapy Evidence Database scale to assess the quality of included studies. Primary outcomes were measures of muscle function, duration of MV, and incidence of mortality. Secondary outcomes were adverse effects and length of stay (LOS) in intensive care unit (ICU) and hospital.</p></sec><sec id="j_fon-2018-0039_s_008_w2aab3b7b7b1b6b1aab1c17b3Aa"><h3>Results</h3><p>Eight trials were included; of those, only one study without standard EM reported that the intervention was invalid to improve the outcomes. The result of meta-analysis indicated that EM shortened the duration of MV; however, it had no positive effect on mortality and LOS in ICU.</p></sec><sec id="j_fon-2018-0039_s_009_w2aab3b7b7b1b6b1aab1c17b4Aa"><h3>Conclusions</h3><p>This review suggests that EM improves the muscle function and ventilation duration. Further research highlighting standard intervention and specific groups is needed.</p></sec></abstract>

BackgroundEarly mobilization (EM) is a regimen that was carried out by physiotherapists in a relatively early stage. It has been investigated by an increasing number of researchers. However, there has not been a meta-analysis concerning whether EM could benefit the clinical outcomes of critically ill patients requiring mechanical ventilation (MV). The present systematic review aims to evaluate the effect of EM compared with immobilization for mechanically ventilated patients.MethodsA computerized literature search was performed in six databases for related articles from inception to June 2017. We included randomized controlled trials and controlled clinical trials and used the Physiotherapy Evidence Database scale to assess the quality of included studies. Primary outcomes were measures of muscle function, duration of MV, and incidence of mortality. Secondary outcomes were adverse effects and length of stay (LOS) in intensive care unit (ICU) and hospital.ResultsEight trials were included; of those, only one study without standard EM reported that the intervention was invalid to improve the outcomes. The result of meta-analysis indicated that EM shortened the duration of MV; however, it had no positive effect on mortality and LOS in ICU.ConclusionsThis review suggests that EM improves the muscle function and ventilation duration. Further research highlighting standard intervention and specific groups is needed.

Early mobilization for mechanically ventilated patients in the intensive care unit: a systematic review and meta-analysis

Frontiers of Nursing

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

BackgroundEarly mobilization (EM) is a regimen that was carried out by physiotherapists in a relatively early stage. It has been investigated by an increasing...

Early mobilization for mechanically ventilated patients in the intensive care unit: a systematic review and meta-analysis

Article Category: Original article

Published Online: Dec 31, 2018

Page range: 301 - 310

Received: Aug 11, 2017

Accepted: Mar 26, 2018

DOI: https://doi.org/10.1515/fon-2018-0039

Keywords
early mobilization, exercise, mechanical ventilation, intensive care unit, meta-analysis, review

© 2018 Meng Yue et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Early mobilization for mechanically ventilated patients in the intensive care unit: a systematic review and meta-analysis

Article Category: Original article

Published Online: Dec 31, 2018

Page range: 301 - 310

Received: Aug 11, 2017

Accepted: Mar 26, 2018

DOI: https://doi.org/10.1515/fon-2018-0039

Keywordsearly mobilization, exercise, mechanical ventilation, intensive care unit, meta-analysis, review

© 2018 Meng Yue et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
early mobilization, exercise, mechanical ventilation, intensive care unit, meta-analysis, review