<abstract xmlns="http://www.w3.org/1999/xhtml"> Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.</abstract>

Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.

Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Regulation of the Ca3.2 calcium channels in health and disease Regulácia Ca3.2 vápnikových kanálov v zdraví a chorobe

Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical...

Regulation of the Ca_V3.2 calcium channels in health and disease Regulácia Ca_V3.2 vápnikových kanálov v zdraví a chorobe

Publié en ligne: 30 nov. 2017

Pages: 15 - 21

Reçu: 24 oct. 2016

Accepté: 16 mars 2017

DOI: https://doi.org/10.1515/afpuc-2017-0019

Mots clés
T-type calcium channel - CaV3.2 - regulation - trafficking - glycosylation

© by Ľ. Lacinová

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe

Publié en ligne: 30 nov. 2017

Pages: 15 - 21

Reçu: 24 oct. 2016

Accepté: 16 mars 2017

DOI: https://doi.org/10.1515/afpuc-2017-0019

Mots clésT-type calcium channel - CaV3.2 - regulation - trafficking - glycosylation

© by Ľ. Lacinová

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Regulation of the Ca_V3.2 calcium channels in health and disease Regulácia Ca_V3.2 vápnikových kanálov v zdraví a chorobe

Mots clés
T-type calcium channel - CaV3.2 - regulation - trafficking - glycosylation