<abstract xmlns="http://www.w3.org/1999/xhtml"> Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.</abstract>

Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.

Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Regulation of the Ca3.2 calcium channels in health and disease Regulácia Ca3.2 vápnikových kanálov v zdraví a chorobe

Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical...

Regulation of the Ca_V3.2 calcium channels in health and disease Regulácia Ca_V3.2 vápnikových kanálov v zdraví a chorobe

Published Online: Nov 30, 2017

Page range: 15 - 21

Received: Oct 24, 2016

Accepted: Mar 16, 2017

DOI: https://doi.org/10.1515/afpuc-2017-0019

Keywords
T-type calcium channel - CaV3.2 - regulation - trafficking - glycosylation

© by Ľ. Lacinová

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe

Published Online: Nov 30, 2017

Page range: 15 - 21

Received: Oct 24, 2016

Accepted: Mar 16, 2017

DOI: https://doi.org/10.1515/afpuc-2017-0019

KeywordsT-type calcium channel - CaV3.2 - regulation - trafficking - glycosylation

© by Ľ. Lacinová

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Regulation of the Ca_V3.2 calcium channels in health and disease Regulácia Ca_V3.2 vápnikových kanálov v zdraví a chorobe

Keywords
T-type calcium channel - CaV3.2 - regulation - trafficking - glycosylation