Investigation of the Therapeutic Effects of Chloroquine in Adriamycin-Induced Hepatotoxicity

1Ölgen S BaI, Nebioğlu D. Angiogenesis and New Aspects of Cancer Chemotherapy. Journal of Faculty of Pharmacy of Ankara University. 2002;31 (3):193-214.ÖlgenS BaINebioğluDAngiogenesis and New Aspects of Cancer ChemotherapyJournal of Faculty of Pharmacy of Ankara University2002313193214Search in Google Scholar

2Meister LA MALeocctCPP, 102-131. Late effects of childhood cancer therapy. Current Problems in Pediatrics 1993 23:102-31.MeisterLAMALeocctCPP, 102-131Late effects of childhood cancer therapyCurrent Problems in Pediatrics1993231023110.1016/0045-9380(93)90019-9Search in Google Scholar

3Doroshow JH, Locker GY, Myers CE. Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin. J Clin Invest. 1980;65(1):128-35.DoroshowJHLockerGYMyersCEEnzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicinJ Clin Invest19806511283510.1172/JCI1096423713477350193Search in Google Scholar

4Kısmet E DE, Yurttutan N, Berberoğlu S, Karademir S, Aydın Hİ, Kalman S, Köseoğlu V. Serum BNP levels in children treated with Doxorubicin for their solif tumors. Gülhane Tıp Dergisi 2004;46(1):38-42.KısmetE DEYurttutanNBerberoğluSKarademirSAydınHİKalmanSKöseoğluV.Serum BNP levels in children treated with Doxorubicin for their solif tumorsGülhane Tıp Dergisi20044613842Search in Google Scholar

5Liu Y, Yang Y, Liu X, Jiang T. Quantification of pegylated liposomal doxorubicin and doxorubicinol in rat plasma by liquid chromatography/electrospray tandem mass spectroscopy: Application to preclinical pharmacokinetic studies. Talanta. 2008;74(4):887-95.LiuYYangYLiuXJiangTQuantification of pegylated liposomal doxorubicin and doxorubicinol in rat plasma by liquid chromatography/electrospray tandem mass spectroscopy: Application to preclinical pharmacokinetic studiesTalanta20087448879510.1016/j.talanta.2007.07.02218371724Search in Google Scholar

6Wallace K. Doxorubicin-induced cardiac mitochondrionopathy. Pharmacology and Toxicology. 2003;93(3):105-15.WallaceKDoxorubicin-induced cardiac mitochondrionopathyPharmacology and Toxicology20039331051510.1034/j.1600-0773.2003.930301.x12969434Search in Google Scholar

7Li J, Li L, Li X, Wu S. Long noncoding RNA LINC00339 aggravates doxorubicin-induced cardiomyocyte apoptosis by targeting MiR-484. Biochem Biophys Res Commun. 2018;503(4):3038-43.LiJLiLLiXWuSLong noncoding RNA LINC00339 aggravates doxorubicin-induced cardiomyocyte apoptosis by targeting MiR-484Biochem Biophys Res Commun2018503430384310.1016/j.bbrc.2018.08.09030170730Search in Google Scholar

8El-Sayed EM, Mansour AM, El-Sawy WS. Protective effect of proanthocyanidins against doxorubicin-induced nephrotoxicity in rats. J Biochem Mol Toxicol. 2017;31(11).El-SayedEMMansourAMEl-SawyWSProtective effect of proanthocyanidins against doxorubicin-induced nephrotoxicity in ratsJ Biochem Mol Toxicol2017311110.1002/jbt.2196528759702Search in Google Scholar

9Omobowale TO, Oyagbemi AA, Ajufo UE, Adejumobi OA, Ola-Davies OE, Adedapo AA, et al. Ameliorative Effect of Gallic Acid in Doxorubicin-Induced Hepatotoxicity in Wistar Rats Through Antioxidant Defense System. J Diet Suppl. 2018;15(2):183-96.OmobowaleTOOyagbemiAAAjufoUEAdejumobiOAOla-DaviesOEAdedapoAAet alAmeliorative Effect of Gallic Acid in Doxorubicin-Induced Hepatotoxicity in Wistar Rats Through Antioxidant Defense SystemJ Diet Suppl20181521839610.1080/19390211.2017.133582228718673Search in Google Scholar

10Hozayen W. Effect of hesperidin and rutin on doxorubicin induced testicular toxicity in male rats. International Journal of Food Sciences and Nutrition. 2012;1:31-42.HozayenWEffect of hesperidin and rutin on doxorubicin induced testicular toxicity in male ratsInternational Journal of Food Sciences and Nutrition201213142Search in Google Scholar

11Fimognari C, Sestili P, Lenzi M, Bucchini A, Cantelli-Forti G, Hrelia P. RNA as a new target for toxic and protective agents. Mutat Res. 2008;648(1-2):15-22.FimognariCSestiliPLenziMBucchiniACantelli-FortiGHreliaPRNA as a new target for toxic and protective agentsMutat Res20086481-2152210.1016/j.mrfmmm.2008.09.00318840453Search in Google Scholar

12Pang B, Qiao X, Janssen L, Velds A, Groothuis T, Kerkhoven R, et al. Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nat Commun. 2013;4:1908.PangBQiaoXJanssenLVeldsAGroothuisTKerkhovenRet alDrug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicinNat Commun20134190810.1038/ncomms2921367428023715267Search in Google Scholar

13Bilgic S, Ozgocmen M. The protective effect of misoprostol against doxorubicin induced liver injury. Biotech Histochem. 2019;94(8):583-91.BilgicSOzgocmenMThe protective effect of misoprostol against doxorubicin induced liver injuryBiotech Histochem20199485839110.1080/10520295.2019.160545731478750Search in Google Scholar

14Liu J, Qu W, Kadiiska MB. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol. 2009;238(3):209-14.LiuJQuWKadiiskaMBRole of oxidative stress in cadmium toxicity and carcinogenesisToxicol Appl Pharmacol200923832091410.1016/j.taap.2009.01.029428735719236887Search in Google Scholar

15Noronha IL, Niemir Z, Stein H, Waldherr R. Cytokines and growth factors in renal disease. Nephrol Dial Transplant. 1995;10(6):775-86.NoronhaILNiemirZSteinHWaldherrRCytokines and growth factors in renal diseaseNephrol Dial Transplant199510677586Search in Google Scholar

16Azuma MM, Gomes-Filho JE, Prieto AKC, Samuel RO, de Lima VMF, Sumida DH, et al. Diabetes increases interleukin-17 levels in periapical, hepatic, and renal tissues in rats. Arch Oral Biol. 2017;83:230-5.AzumaMMGomes-FilhoJEPrietoAKCSamuelROde LimaVMFSumidaDHet alDiabetes increases interleukin-17 levels in periapical, hepatic, and renal tissues in ratsArch Oral Biol201783230510.1016/j.archoralbio.2017.08.00128818706Search in Google Scholar

17Aggarwal S, Gurney AL. IL-17: prototype member of an emerging cytokine family. J Leukoc Biol. 2002;71(1):1-8.AggarwalSGurneyALIL-17: prototype member of an emerging cytokine familyJ Leukoc Biol200271118Search in Google Scholar

18Yu JJ, Gaffen SL. Interleukin-17: a novel inflammatory cytokine that bridges innate and adaptive immunity. Front Biosci. 2008;13:170-7.YuJJGaffenSLInterleukin-17: a novel inflammatory cytokine that bridges innate and adaptive immunityFront Biosci200813170710.2741/266717981535Search in Google Scholar

19He Y, Yang Z, Li J, Li E. Dexmedetomidine reduces the inflammation and apoptosis of doxorubicin-induced myocardial cells. Exp Mol Pathol. 2020;113:104371.HeYYangZLiJLiEDexmedetomidine reduces the inflammation and apoptosis of doxorubicin-induced myocardial cellsExp Mol Pathol202011310437110.1016/j.yexmp.2020.10437131917290Search in Google Scholar

20Zhang S, You ZQ, Yang L, Li LL, Wu YP, Gu LQ, et al. Protective effect of Shenmai injection on doxorubicin-induced cardiotoxicity via regulation of inflammatory mediators. BMC Complement Altern Med. 2019;19(1):317.ZhangSYouZQYangLLiLLWuYPGuLQet alProtective effect of Shenmai injection on doxorubicin-induced cardiotoxicity via regulation of inflammatory mediatorsBMC Complement Altern Med201919131710.1186/s12906-019-2686-2686279431744501Search in Google Scholar

21Liu Y, Su L, Lin Q, Han Y, You P, Fan Q. Induction of C-Mip by IL-17 Plays an Important Role in Adriamycin-Induced Podocyte Damage. Cell Physiol Biochem. 2015;36(4):1274-90.LiuYSuLLinQHanYYouPFanQInduction of C-Mip by IL-17 Plays an Important Role in Adriamycin-Induced Podocyte DamageCell Physiol Biochem201536412749010.1159/00043029626160339Search in Google Scholar

22Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, et al. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med. 2011;208(3):491-503.MaYAymericLLocherCMattarolloSRDelahayeNFPereiraPet alContribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapyJ Exp Med2011208349150310.1084/jem.20100269305857521383056Search in Google Scholar

23Ben-Zvi I, Kivity S, Langevitz P, Shoenfeld Y. Hydroxychloroquine: from malaria to autoimmunity. Clin Rev Allergy Immunol. 2012;42(2):145-53.Ben-ZviIKivitySLangevitzPShoenfeldY.Hydroxychloroquine: from malaria to autoimmunityClin Rev Allergy Immunol20124221455310.1007/s12016-010-8243-x709106321221847Search in Google Scholar

24Lalloo DG, Shingadia D, Pasvol G, Chiodini PL, Whitty CJ, Beeching NJ, et al. UK malaria treatment guidelines. J Infect. 2007;54(2):111-21.LallooDGShingadiaDPasvolGChiodiniPLWhittyCJBeechingNJet alUK malaria treatment guidelinesJ Infect20075421112110.1016/j.jinf.2006.12.00317215045Search in Google Scholar

25Rainsford KD, Parke AL, Clifford-Rashotte M, Kean WF. Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases. Inflammopharmacology. 2015;23(5):231-69.RainsfordKDParkeALClifford-RashotteMKeanWFTherapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseasesInflammopharmacology20152352316910.1007/s10787-015-0239-y26246395Search in Google Scholar

26Huang M, Tang T, Pang P, Li M, Ma R, Lu J, et al. Treating COVID-19 with Chloroquine. J Mol Cell Biol. 2020;12(4):322-5.HuangMTangTPangPLiMMaRLuJet alTreating COVID-19 with ChloroquineJ Mol Cell Biol2020124322510.1093/jmcb/mjaa014723213032236562Search in Google Scholar

27Lehmann GL, Carreras FI, Soria LR, Gradilone SA, Marinelli RA. LPS induces the TNF-alpha-mediated down-regulation of rat liver aquaporin-8: role in sepsis-associated cholestasis. Am J Physiol Gastrointest Liver Physiol. 2008;294(2):G567-75.LehmannGLCarrerasFISoriaLRGradiloneSAMarinelliRALPS induces the TNF-alpha-mediated down-regulation of rat liver aquaporin-8: role in sepsis-associated cholestasisAm J Physiol Gastrointest Liver Physiol20082942G5677510.1152/ajpgi.00232.200718174273Search in Google Scholar

28Yang M, Cao L, Xie M, Yu Y, Kang R, Yang L, et al. Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis. Biochem Pharmacol. 2013;86(3):410-8.YangMCaoLXieMYuYKangRYangLet alChloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsisBiochem Pharmacol2013863410810.1016/j.bcp.2013.05.013371308923707973Search in Google Scholar

29Shivakumar P, Rani MU, Reddy AG, Anjaneyulu Y. A study on the toxic effects of Doxorubicin on the histology of certain organs. Toxicol Int. 2012;19(3):241-4.ShivakumarPRaniMUReddyAGAnjaneyuluYA study on the toxic effects of Doxorubicin on the histology of certain organsToxicol Int2012193241410.4103/0971-6580.103656353276723293460Search in Google Scholar

30Long L, Yang X, Southwood M, Lu J, Marciniak SJ, Dunmore BJ, et al. Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. Circ Res. 2013;112(8):1159-70.LongLYangXSouthwoodMLuJMarciniakSJDunmoreBJet alChloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradationCirc Res2013112811597010.1161/CIRCRESAHA.111.30048323446737Search in Google Scholar

31Bayatli F, Akkus D, Kilic E, Saraymen R, Sonmez MF. The protective effects of grape seed extract on MDA, AOPP, apoptosis and eNOS expression in testicular torsion: an experimental study. World J Urol. 2013;31(3):615-22.BayatliFAkkusDKilicESaraymenRSonmezMFThe protective effects of grape seed extract on MDA, AOPP, apoptosis and eNOS expression in testicular torsion: an experimental studyWorld J Urol20133136152210.1007/s00345-013-1049-823475212Search in Google Scholar

32Karabulut D, Ulusoy HB, Kaymak E, Sönmez MF. Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. Anatolian journal of cardiology. 2016;16(5):310-5.KarabulutDUlusoyHBKaymakESönmezMFTherapeutic effects of pentoxifylline on diabetic heart tissue via NOSAnatolian journal of cardiology2016165310510.5152/akd.2015.6252533677726488377Search in Google Scholar

33Öztürk E, Kaymak E, Akin AT, Karabulut D, Ünsal HM, Yakan B. Thymoquinone is a protective agent that reduces the negative effects of doxorubicin in rat testis. Hum Exp Toxicol. 2020:960327120924108.ÖztürkEKaymakEAkinATKarabulutDÜnsalHMYakanBThymoquinone is a protective agent that reduces the negative effects of doxorubicin in rat testisHum Exp Toxicol202096032712092410810.1177/096032712092410832394736Search in Google Scholar

34Afsar T, Razak S, Almajwal A. Effect of Acacia hydaspica R. Parker extract on lipid peroxidation, antioxidant status, liver function test and histopathology in doxorubicin treated rats. Lipids in Health and Disease. 2019;18(1):126.AfsarTRazakSAlmajwalAEffect of Acacia hydaspica RParker extract on lipid peroxidation, antioxidant status, liver function test and histopathology in doxorubicin treated rats. Lipids in Health and Disease201918112610.1186/s12944-019-1051-2654210131142345Search in Google Scholar

35Kuzu M, Yıldırım S, Kandemir FM, Küçükler S, Çağlayan C, Türk E, et al. Protective effect of morin on doxorubicin-induced hepatorenal toxicity in rats. Chem Biol Interact. 2019;308:89-100.KuzuMYıldırımSKandemirFMKüçüklerSÇağlayanCTürkEet alProtective effect of morin on doxorubicin-induced hepatorenal toxicity in ratsChem Biol Interact20193088910010.1016/j.cbi.2019.05.01731100273Search in Google Scholar

36Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, et al. Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF κb Signal. Front Pharmacol. 2019;10:1030.SongSChuLLiangHChenJLiangJHuangZet alProtective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF κb SignalFront Pharmacol201910103010.3389/fphar.2019.01030675363831572199Search in Google Scholar

37Doğanyiğit Z, Yakan B, Okan A, Silici S. Antioxidative role of propolis on LPS induced renal damage. The EuroBiotech Journal. 2020;4:156-60.DoğanyiğitZYakanBOkanASiliciS.Antioxidative role of propolis on LPS induced renal damageThe EuroBiotech Journal202041566010.2478/ebtj-2020-0018Search in Google Scholar

38Karabulut D, Ozturk E, Kuloglu N, Akin AT, Kaymak E, Yakan B. Effects of vitamin B12 on methotrexate hepatotoxicity: evaluation of receptor-interacting protein (RIP) kinase. Naunyn Schmiedebergs Arch Pharmacol. 2020;393(12):2473-80.KarabulutDOzturkEKulogluNAkinATKaymakEYakanBEffects of vitamin B12 on methotrexate hepatotoxicity: evaluation of receptor-interacting protein (RIP) kinaseNaunyn Schmiedebergs Arch Pharmacol20203931224738010.1007/s00210-020-01992-133052426Search in Google Scholar

39Akin A. T. KE, Karabulut D. , Doğanyiğit Z., Ceylan T., Toluk A. , Özdamar S. Comparison of the acute and cumulative dose administrations in doxorubicin-induced hepatotoxicity via evaluation of the histopathological changes and inflammation in rats. Experimental and Applied Medical Science. 2020;1(3):73-81.AkinA. T. KEKarabulutD.DoğanyiğitZ.CeylanT.TolukA.ÖzdamarSComparison of the acute and cumulative dose administrations in doxorubicin-induced hepatotoxicity via evaluation of the histopathological changes and inflammation in ratsExperimental and Applied Medical Science2020137381Search in Google Scholar

40Doğanyiğit Z, Silici S, Demirtaş A, Kaya E, 1. Kaymak E. Determination of histological, immunohistochemical and biochemical effects of acute and chronic grayanotoxin III administration in different doses in rats. Environ Sci Pollut Res Int. 2019;26(2):1323-35.DoğanyiğitZSiliciSDemirtaşAKayaE1KaymakEDetermination of histological, immunohistochemical and biochemical effects of acute and chronic grayanotoxin III administration in different doses in ratsEnviron Sci Pollut Res Int201926213233510.1007/s11356-018-3700-930426365Search in Google Scholar

41Çakır M, Tekin S, Doğanyiğit Z, Çakan P, Kaymak E. The protective effect of cannabinoid type 2 receptor activation on renal ischemia-reperfusion injury. Mol Cell Biochem. 2019;462(1-2):123-32.ÇakırMTekinSDoğanyiğitZÇakanPKaymakEThe protective effect of cannabinoid type 2 receptor activation on renal ischemia-reperfusion injuryMol Cell Biochem20194621-21233210.1007/s11010-019-03616-631446615Search in Google Scholar

42Sönmez MF, Ozdemir Ş, Guzel M, Kaymak E. The ameliorative effects of vinpocetine on apoptosis and HSP-70 expression in testicular torsion in rats. Biotech Histochem. 2017;92(2):92-9.SönmezMFOzdemirŞ, Guzel MKaymakE.The ameliorative effects of vinpocetine on apoptosis and HSP-70 expression in testicular torsion in ratsBiotech Histochem201792292910.1080/10520295.2016.125949928296551Search in Google Scholar