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Using the Initial Systolic Time Interval to assess cardiac autonomic nervous function in Parkinson’s disease

Jan H. Meijer
Jan H. Meijer
, 
Eskeline Elbertse
Eskeline Elbertse
, 
Sanne Boesveldt
Sanne Boesveldt
, 
Henk W. Berendse
Henk W. Berendse
 and 
Rudolph M. Verdaasdonk
Rudolph M. Verdaasdonk
   | Dec 19, 2011
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Article Category: Articles
Published Online: Dec 19, 2011
Page range: 98 - 101
Received: Nov 30, 2011
DOI: https://doi.org/10.5617/jeb.216
Keywords
© 2011 Jan H. Meijer, Eskeline Elbertse, Sanne Boesveldt, Henk W. Berendse and Rudolph M. Verdaasdonk, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig.1

Electrode configuration for the measurement of ISTI: A small electrical current i was applied to the upper part of the body by means of the two outer electrodes. The two inner electrodes measured the subsequent electrical voltage difference V over the heart from which the impedance Z was computed.
Electrode configuration for the measurement of ISTI: A small electrical current i was applied to the upper part of the body by means of the two outer electrodes. The two inner electrodes measured the subsequent electrical voltage difference V over the heart from which the impedance Z was computed.

Fig.2

Simultaneous registration of an Impedance CardioGram (ICG) and an ElectroCardioGram (ECG) (arbitrary units). ISTI is defined as the time interval between the R-point in the ECG and the C-point in the ICG.
Simultaneous registration of an Impedance CardioGram (ICG) and an ElectroCardioGram (ECG) (arbitrary units). ISTI is defined as the time interval between the R-point in the ECG and the C-point in the ICG.

Fig.3

Variability in RR-interval (RR-VAR) in the group of patients suffering from Parkinson’s disease and in the control group, during normal breathing at rest and during stimulated, deep breathing. At rest there is no significant difference between the two groups. During stimulated deep breathing RR-VAR increased significantly within both groups. However, this increase was significantly less in the patient group.
Variability in RR-interval (RR-VAR) in the group of patients suffering from Parkinson’s disease and in the control group, during normal breathing at rest and during stimulated, deep breathing. At rest there is no significant difference between the two groups. During stimulated deep breathing RR-VAR increased significantly within both groups. However, this increase was significantly less in the patient group.

Fig.4

Variability in ISTI (ISTI-VAR) in the group of patients suffering from Parkinson’s disease and in the control group, during normal breathing at rest and during stimulated, deep breathing. At rest there is a significant difference between the two groups. During stimulated deep breathing ISTI-VAR increased significantly in the control group. However, ISTI-VAR did not change significantly in the patient group as it was already substantially elevated.
Variability in ISTI (ISTI-VAR) in the group of patients suffering from Parkinson’s disease and in the control group, during normal breathing at rest and during stimulated, deep breathing. At rest there is a significant difference between the two groups. During stimulated deep breathing ISTI-VAR increased significantly in the control group. However, ISTI-VAR did not change significantly in the patient group as it was already substantially elevated.

ISTI-interval ± S.D. [ms] in the group of patients with Parkinson’s disease and in the group of control subjects while breathing at rest and during stimulated, deep breathing at 0.1 Hz.

subjectsISTI [ms] at restISTI [ms] stimulated
controls (24)145 ± 14147 ± 10
patients (18)143 ± 17147 ± 19

Variability in ISTI (ISTI-VAR) ± S.D. [%] in the group of patients with Parkinson’s disease and in the group of control subjects while breathing at rest and during stimulated, deep breathing at 0.1 Hz.

subjectsISTI-VAR [%] at restISTI-VAR [%] stimulated
controls (24)23 ± 1534 ± 17
patients (18)44 ± 4038 ± 20

Variability in RR-interval (RR-VAR) ± S.D. [%] in the group of patients with Parkinson’s disease and in the group of control subjects while breathing at rest and during stimulated, deep breathing at 0.1 Hz.

subjectsRR-VAR [%] at restRR-VAR [%] stimulated
controls (24)19 ± 1031 ± 12
patients (19)17 ± 723 ± 10

RR-interval ± S.D. [ms] in the group of patients with Parkinson’s disease and in the group of control subjects while breathing at rest and during stimulated, deep breathing at 0.1 Hz.

subjectsRR [ms] at restRR [ms] stimulated
controls (24)990 ± 180990 ± 170
patients (19)940 ± 170940 ± 170
eISSN:
1891-5469
Language:
English
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Journal Subjects:
Engineering, Bioengineering and Biomedical Engineering, Biomedical Electronics, Life Sciences, Biophysics, Medicine, Biomedical Engineering, Physics, Spectroscopy and Metrology
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