<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The Initial Systolic Time Interval (ISTI) has been defined as the time difference between the peak electrical and peak mechanical activity of the heart. ISTI is obtained from the electro-cardiogram and the impedance cardiogram. The response of ISTI while breathing at rest and to a deep breathing stimulus was studied in a group of patients suffering from Parkinson’s disease (PD) and a group of healthy control subjects. ISTI showed substantial variability during these manoeuvres. The tests showed that the variability of RR and ISTI was substantially different between PD patients and controls. It is hypothesized that in PD patients the sympathetic nervous system compensates for the loss of regulatory control function of the blood-pressure by the parasympathetic system. It is concluded that ISTI is a practical, additional and independent parameter that can be used to assist other tests in evaluating autonomic nervous control of the heart in PD patients.</p></abstract>

The Initial Systolic Time Interval (ISTI) has been defined as the time difference between the peak electrical and peak mechanical activity of the heart. ISTI is obtained from the electro-cardiogram and the impedance cardiogram. The response of ISTI while breathing at rest and to a deep breathing stimulus was studied in a group of patients suffering from Parkinson’s disease (PD) and a group of healthy control subjects. ISTI showed substantial variability during these manoeuvres. The tests showed that the variability of RR and ISTI was substantially different between PD patients and controls. It is hypothesized that in PD patients the sympathetic nervous system compensates for the loss of regulatory control function of the blood-pressure by the parasympathetic system. It is concluded that ISTI is a practical, additional and independent parameter that can be used to assist other tests in evaluating autonomic nervous control of the heart in PD patients.

Using the Initial Systolic Time Interval to assess cardiac autonomic nervous function in Parkinson’s disease

Journal of Electrical Bioimpedance

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Initial Systolic Time Interval (ISTI) has been defined as the time difference between the peak electrical and peak mechanical activity of the heart. ISTI...

Using the Initial Systolic Time Interval to assess cardiac autonomic nervous function in Parkinson’s disease

Article Category: Articles

Published Online: Dec 19, 2011

Page range: 98 - 101

Received: Nov 30, 2011

DOI: https://doi.org/10.5617/jeb.216

Keywords
Initial systolic time interval, Impedance cardiography, Parkinson’s disease, cardiac autonomic nervous function

© 2011 Jan H. Meijer, Eskeline Elbertse, Sanne Boesveldt, Henk W. Berendse and Rudolph M. Verdaasdonk, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Using the Initial Systolic Time Interval to assess cardiac autonomic nervous function in Parkinson’s disease

Article Category: Articles

Published Online: Dec 19, 2011

Page range: 98 - 101

Received: Nov 30, 2011

DOI: https://doi.org/10.5617/jeb.216

KeywordsInitial systolic time interval, Impedance cardiography, Parkinson’s disease, cardiac autonomic nervous function

© 2011 Jan H. Meijer, Eskeline Elbertse, Sanne Boesveldt, Henk W. Berendse and Rudolph M. Verdaasdonk, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Initial systolic time interval, Impedance cardiography, Parkinson’s disease, cardiac autonomic nervous function