<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.1002.476_s_001_w2aab3b7b6b1b6b1aab1c16b1Aa"><h3>Background</h3><p>The effects and associations of genetic variation, psychological, and environment factors associated with cigarette smoking and nicotine dependence remain largely unknown.</p></sec><sec id="j_1905-7415.1002.476_s_002_w2aab3b7b6b1b6b1aab1c16b2Aa"><h3>Objective</h3><p>To determine the influence and association of functional genetic polymorphisms of cytochrome P450 2A6 (CYP2A6), anxiety, and environmental factors on cigarette smoking and nicotine dependence.</p></sec><sec id="j_1905-7415.1002.476_s_003_w2aab3b7b6b1b6b1aab1c16b3Aa"><h3>Method</h3><p>A cross-sectional study was conducted at King Chulalongkorn Memorial Hospital, Thailand between October 2014 and June 2015. We recruited 127 Thai adult smokers when they visited for an annual physical check-up. Participants completed questionnaires regarding demographic characteristics, The Fagerstrom Test for Nicotine Dependence, and The Thai Hospital Anxiety and Depression Scale. Blood was collected for CYP2A6 genotyping to determine the enzyme metabolism level/group.</p></sec><sec id="j_1905-7415.1002.476_s_004_w2aab3b7b6b1b6b1aab1c16b4Aa"><h3>Results</h3><p>Factors associated with significantly greater cigarette consumption were age and being ultrarapid/ extensive metabolizers (UM/EM). Anxiety and smoking by household family members were significantly associated with the degree of nicotine dependence. We observed associations between severe nicotine dependence and genotype (UM/EM) and age (b = 0.037; P = 0.005), intermediate metabolizers (IM) and age (b = 0.031; P = 0.43), UM/EM and anxiety (b = 0.258; P &lt; 0.001), IM and anxiety (b = 0.285; P &lt; 0.001), UM/EM and household smoking in the family members (b = 1.427; P = 0.003), and IM and smoking by household family members (b = 1.293; P = 0.024).</p></sec><sec id="j_1905-7415.1002.476_s_005_w2aab3b7b6b1b6b1aab1c16b5Aa"><h3>Conclusions</h3><p>Information regarding the association between the gene encoding enzyme metabolism, anxiety, and their interactions may be beneficial for selecting treatment choices for smoking cessation for individual genotypic metabolizers.</p></sec></abstract>

BackgroundThe effects and associations of genetic variation, psychological, and environment factors associated with cigarette smoking and nicotine dependence remain largely unknown.ObjectiveTo determine the influence and association of functional genetic polymorphisms of cytochrome P450 2A6 (CYP2A6), anxiety, and environmental factors on cigarette smoking and nicotine dependence.MethodA cross-sectional study was conducted at King Chulalongkorn Memorial Hospital, Thailand between October 2014 and June 2015. We recruited 127 Thai adult smokers when they visited for an annual physical check-up. Participants completed questionnaires regarding demographic characteristics, The Fagerstrom Test for Nicotine Dependence, and The Thai Hospital Anxiety and Depression Scale. Blood was collected for CYP2A6 genotyping to determine the enzyme metabolism level/group.ResultsFactors associated with significantly greater cigarette consumption were age and being ultrarapid/ extensive metabolizers (UM/EM). Anxiety and smoking by household family members were significantly associated with the degree of nicotine dependence. We observed associations between severe nicotine dependence and genotype (UM/EM) and age (b = 0.037; P = 0.005), intermediate metabolizers (IM) and age (b = 0.031; P = 0.43), UM/EM and anxiety (b = 0.258; P < 0.001), IM and anxiety (b = 0.285; P < 0.001), UM/EM and household smoking in the family members (b = 1.427; P = 0.003), and IM and smoking by household family members (b = 1.293; P = 0.024).ConclusionsInformation regarding the association between the gene encoding enzyme metabolism, anxiety, and their interactions may be beneficial for selecting treatment choices for smoking cessation for individual genotypic metabolizers.

Association of cytochrome P450 2A6 polymorphism, anxiety, and environmental factors with cigarette smoking by Thai adults

Clinical Pharmacokinetics Research Unit in Renal and Cardiovascular Diseases

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundThe effects and associations of genetic variation, psychological, and environment factors associated with cigarette smoking and nicotine dependence...

Association of cytochrome P450 2A6 polymorphism, anxiety, and environmental factors with cigarette smoking by Thai adults

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 147 - 154

DOI: https://doi.org/10.5372/1905-7415.1002.476

Keywords
Anxiety, cigarette smoking, cytochrome P450 2A6 polymorphism

© 2016 Napakkawat Buathong, Rasmon Kalayasiri, Pajaree Chaliyavilaskul, Khwanruan Phetnoi, Thanapoom Ratananupong

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Association of cytochrome P450 2A6 polymorphism, anxiety, and environmental factors with cigarette smoking by Thai adults

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 147 - 154

DOI: https://doi.org/10.5372/1905-7415.1002.476

KeywordsAnxiety, cigarette smoking, cytochrome P450 2A6 polymorphism

© 2016 Napakkawat Buathong, Rasmon Kalayasiri, Pajaree Chaliyavilaskul, Khwanruan Phetnoi, Thanapoom Ratananupong

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Anxiety, cigarette smoking, cytochrome P450 2A6 polymorphism