<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.0901.372_s_101_w2aab3b7c12b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Osteoporosis is a metabolic bone disease with a risk factor of being female, particularly after the onset of menopause.</p></sec><sec id="j_1905-7415.0901.372_s_102_w2aab3b7c12b1b6b1aab1c16b2Aa"><h3>Objectives</h3><p>To evaluate the influence of age, anthropometric, and reproductive variables on spinal bone mineral density (BMD) in women with postmenopausal vertebral osteoporosis.</p></sec><sec id="j_1905-7415.0901.372_s_103_w2aab3b7c12b1b6b1aab1c16b3Aa"><h3>Methods</h3><p>The study was retrospective and included data from 171 patients with postmenopausal vertebral osteoporosis. We performed both simple and multiple regressions considering BMD in spine as the dependent variable. Coefficients of correlation (<italic>r</italic>), coefficients of determination (<italic>r</italic><sup>2</sup>), and their level of significance were calculated.</p></sec><sec id="j_1905-7415.0901.372_s_104_w2aab3b7c12b1b6b1aab1c16b4Aa"><h3>Results</h3><p>The associations between spinal BMD and each of the following variables were extremely significant: age at menarche (<italic>P</italic> = 0.0003), weight (<italic>P</italic> &lt; 0.0001), stature (<italic>P</italic> = 0.0004), and BMI (<italic>P</italic> &lt; 0.0001). The associations between spinal BMD and age (<italic>P</italic> = 0.004), and between spinal BMD and number of years after menopause were very significant (P = 0.0093). BMD was not associated with age at menopause or number of reproductive years. For multiple regressions there was an increasing trend of <italic>r</italic><sup>2</sup> with increasing number of independent variables included in the analysis: <italic>r</italic><sup>2</sup> = 21.84% (2 variables), <italic>r</italic><sup>2</sup> = 24.93% (3 variables), 26.45% (4 variables), and <italic>r</italic><sup>2</sup> = 27% (5 variables).</p></sec><sec id="j_1905-7415.0901.372_s_105_w2aab3b7c12b1b6b1aab1c16b5Aa"><h3>Conclusion</h3><p>BMD is positively associated with weight, BMI, and stature, and is negatively associated with age, time of menarche, and years after menopause. BMD is not associated with age at menopause and reproductive period.</p></sec></abstract>

BackgroundOsteoporosis is a metabolic bone disease with a risk factor of being female, particularly after the onset of menopause.ObjectivesTo evaluate the influence of age, anthropometric, and reproductive variables on spinal bone mineral density (BMD) in women with postmenopausal vertebral osteoporosis.MethodsThe study was retrospective and included data from 171 patients with postmenopausal vertebral osteoporosis. We performed both simple and multiple regressions considering BMD in spine as the dependent variable. Coefficients of correlation (r), coefficients of determination (r2), and their level of significance were calculated.ResultsThe associations between spinal BMD and each of the following variables were extremely significant: age at menarche (P = 0.0003), weight (P < 0.0001), stature (P = 0.0004), and BMI (P < 0.0001). The associations between spinal BMD and age (P = 0.004), and between spinal BMD and number of years after menopause were very significant (P = 0.0093). BMD was not associated with age at menopause or number of reproductive years. For multiple regressions there was an increasing trend of r2 with increasing number of independent variables included in the analysis: r2 = 21.84% (2 variables), r2 = 24.93% (3 variables), 26.45% (4 variables), and r2 = 27% (5 variables).ConclusionBMD is positively associated with weight, BMI, and stature, and is negatively associated with age, time of menarche, and years after menopause. BMD is not associated with age at menopause and reproductive period.

Body weight, BMI, and stature have a protective effect on bone mineral density in women with postmenopausal vertebral osteoporosis, whereas greater age at menarche and years after menopause have a negative effect

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundOsteoporosis is a metabolic bone disease with a risk factor of being female, particularly after the onset of menopause.ObjectivesTo evaluate the...

Independent variable	r	P
Age	-0.22	0.004 P < 0.01 = very significant,
Age at menarche	-0.27	0.0003 P < 0.001 = very significant,
Age at menopause	-0.02	0.715
Reproductive period	0.05	0.506
Number of years after menopause	-0.19	0.0093 P < 0.01 = very significant,
Weight	0.42	<0.0001 P < 0.001 = very significant,
Body mass index	0.31	<0.0001 P < 0.001 = very significant,
Stature	0.26	0.0004 P < 0.001 = very significant,

Variable	Min.	Max.	Mean ± SD
Age	33	70	57.8 ± 7.6
Age at menarche (y)	10	19	13.9 ± 1.7
Age at menopause (y)	22	58	45.3 ± 5.8
Reproductive period (y)	5	44	31.4 ± 6.0
Number of years after menopause (y)	1	34	12.5 ± 12.5
Stature (m)	1.40	1.75	1.6 ± 0.1
Weight (kg)	36	98	63.7 ± 11.5
BMI (kg/m²)	14.8	38.4	25.5 ± 4.5
Bone mineral density in spine (g/cm²)	0.24	0.77	0.68 ± 0.08

Body weight, BMI, and stature have a protective effect on bone mineral density in women with postmenopausal vertebral osteoporosis, whereas greater age at menarche and years after menopause have a negative effect

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 81 - 86

DOI: https://doi.org/10.5372/1905-7415.0901.372

Keywords
Age, bone mineral density, menarche, menopause, osteoporosis, stature, weight

© 2017 Rodica Török-Oance, Melania Bala’

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Correlation coefficient (r) and significance of simple linear regression between bone mineral density (BMD) in spine and age, anthropometric, and reproductive factors.

Patient characteristics

Body weight, BMI, and stature have a protective effect on bone mineral density in women with postmenopausal vertebral osteoporosis, whereas greater age at menarche and years after menopause have a negative effect

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 81 - 86

DOI: https://doi.org/10.5372/1905-7415.0901.372

KeywordsAge, bone mineral density, menarche, menopause, osteoporosis, stature, weight

© 2017 Rodica Török-Oance, Melania Bala’

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Correlation coefficient (r) and significance of simple linear regression between bone mineral density (BMD) in spine and age, anthropometric, and reproductive factors.

Patient characteristics

Keywords
Age, bone mineral density, menarche, menopause, osteoporosis, stature, weight