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Impact of perioperative treatment on survival of resectable gastric cancer patients after D2 lymphadenectomy: a single European centre propensity score matching analysis


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Figure 1

Overall survival of patients in Surgery compared to Surgery with chemotherapy group.Surgery+CT = surgery with chemotherapy group
Overall survival of patients in Surgery compared to Surgery with chemotherapy group.Surgery+CT = surgery with chemotherapy group

Figure 2

Overall survival of patients in Surgery compared to Surgery with chemotherapy group in different TNM T stages.Surgery+CT: Surgery with chemotherapy
Overall survival of patients in Surgery compared to Surgery with chemotherapy group in different TNM T stages.Surgery+CT: Surgery with chemotherapy

Figure 3

Overall survival of patients with surgery compared to patients with surgery and chemotherapy in different TNM N stages.Surgery+CT: surgery with chemotherapy
Overall survival of patients with surgery compared to patients with surgery and chemotherapy in different TNM N stages.Surgery+CT: surgery with chemotherapy

Clinicopathological characteristics of the gastric cancer patients

Clinicopathological characteristicAll patientsSurgery onlyPerioperative and adjuvant treatmentP
(n = 482)(n = 241)(n = 241)
Age [years ± SD]62.2 ± 11.262.02 ± 12.362.35 ± 9.9NS
Gender [n(%)]NS
Male322 (66.8)153 (63.5)169 (70.1)
Female160 (33.2)88 (36.5)72 (29.9)
Capecitabine 111(46)
EOX 91(37.7)
XELOX 16(6.6)
Type of chemotherapy [n (%)]*5FUCP 19(7.9)
5FULV 3(1.2)
Paclitaxel+CP 1(0.4)
Tumor site
Distal third151 (31.3)75 (31.1)76 (31.5)
Middle third226 (46.9)113 (46.9)113 (46.9)NS
Proximal third85 (17.6)38 (15.8)47 (19.5)
Whole stomach11 (2.3)7 (2.9)4 (1.7)
Stump9 (1.9)8 (3.3)1 (0.4)
ASA score [n (%)]0.044
I188 (39)90 (37.3)98 (40.7)
II239 (49.6)113 (46.9)126 (52.3)
III55 (11.4)38 (15.8)17 (7.1)
T stage [n (%)]NS
T06 (1.2)2 (0.8)4 (1.7)
T162 (12.9)36 (14.9)26 (10.8)
T275 (15.6)35 (14.5)40 (16.6)
T3266 (55.2)138 (57.3)128 (53.1)
T473 (15.1)30 (12.4)43 (17.8)
N stage [n (%)]NS
N0158 (32.8)86 (35.7)72 (29.9)
N182 (17)31 (12.9)51 (21.2)
N297 (20.1)42 (17.4)55 (22.8)
N3a89 (18.5)53 (22)36 (14.9)
N3b56 (11.6)29 (12)27 (11.2)
UICC stage [n (%)]
08 (8)1 (0.4)3 (1.2)
Ia54 (11.2)35 (14.5)19 (7.9)
Ib35 (7.3)16 (6.6)19 (7.9)
IIa73 (15.1)36 (14.9)37 (15.4)
IIb83 (17.2)30 (12.4)53 (22)NS
IIc2 (0.4)2 (0.8)0 (0)
IIIa94 (19.5)44 (18.3)50 (20.7)
IIIb79 (16.4)47 (19.5)32 (13.3)
IIIc57 (11.8)30 (12.4)27 (11.2)
IV1 (0.2)0 (0)1 (0.4)
Clavien-Dindo classification [n (%)]
0388 (80.5)197 (81.7)191 (79.3)NS
I0 (0.0)0 (0)0 (0)
II44 (9.1)14 (5.8)30 (12.4)
IIIa10 (2.1)3 (1.2)7 (2.9)
IIIb27 (5.6)16 (6.6)11 (4.6)
IV0 (0)0 (0)0 (0)
V13 (2.7)11 (4.6)2 (0.8)
Number of extracted LNs [n ± SD]25.6 ± 13.124.9 ± 13.526.3 ± 12.6NS
Number of positive LNs [n ± SD]6.2 ± 9.36.8 ± 10.55.6 ± 8NS
Tumour [mm ± SD] diameter59.4 ± 35.861.4 ± 38.657.6 ± 33.3NS
CEA [μg/l ± SD]5 ± 14.54.25 ± 10.95.7 ± 16.9NS
CA 19-9 [μU/l ± SD]135.1 ± 799.566.8 ± 287.8189.9 ± 1037.3NS
Perioperative morbidity [%]9 (33.3)2 (28.6)7 (35)NS
Mortality [%]0 (0)0 (0)0 (0)NS

Predictors of survival

SignificanceHR95.0% CI for HR
LowerUpper
Age0.0001.0241.0111.037
CA 19-90.0161.0001.0001.000
UICC stage0.0002.1471.6772.748
Positive lymph nodes0.0001.0301.0171.044
Perioperative therapy0.0320.7410.5630.975

Recorded reccurence patterns for T and N stage

Peritoneal carcinomatosis [n (%)]Haemathogenous spread [n (%)]P
T stage
T10 (0)0 (0)
T21 (8.3)4 (36.4)0.019
T35 (41.7)6 (54.5)
T46 (50)1 (9.1)
N stage
N02 (16.7)1 (9.1)
N11 (8.3)2 (18.2)
N23 (25)6 (54.5)NS
N3a4 (33.3)1 (9.1)
N3b2 (16.7)1 (9.1)
eISSN:
1581-3207
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Clinical Medicine, Radiology, Internal Medicine, Haematology, Oncology