Prognosing a severe course of asthma in children following the study of endothelial function
, , and | Oct 11, 2019
About this article
Article Category: Original Papers
Published Online: Oct 11, 2019
Page range: 68 - 74
DOI: https://doi.org/10.2478/pneum-2019-0014
Keywords
© 2019 Amanda et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
General characteristics of children with persistent BA
| Group 1 | Group 2 | Group 3 | ||
|---|---|---|---|---|
| Age, years | 10.78 ± 3.62 | 10.75 ± 2.83 | 10.94 ± 3.14 | |
| mean ± SD | ||||
| Girls/boys | 22/18 | 18/16 | 7/10 | |
| Duration of the disease (years) | 3 (1; 4) | 5 (2; 7) | 9 (6; 11) | |
| Median (IQR) | ||||
| Concomitant allergic disorders | 22 (55%) | 16 (47%) | 14 (82%) | |
| Positive family allergic history | 27 (68%) | 20 (59%) | 16 (94%) | |
| Recurrent respiratory diseases | 11 (28%) | 21 (62%) | 15 (88%) | |
| PFT | 94.0 (85.0; 100.5) | 85.5 (80.0; 91.0) | 81.0 (79.0; 86.0) | |
| FEV,% 1 | 87.0 (80.0; 94.5) | 92.0 (86.0; 97.0) | 79.0 (70.0; 85.0) | |
| FEF,% 25 | 87.5 (81.0; 95.5) | 91.0 (85.0; 96.0) | 82.0 (77.0; 87.0) | |
| FEF50,% | 88.5 (82.0; 95.0) | 86.0 (81.0; 92.0) | 84.0 (79.0; 89.0) | |
| FEF75,% | ||||
| IgE, IU/ml | 456.1 (248.0; 698.0) | 577.0 (180.1; 812.3) | 249.3 (65.7; 440.6) | |
| Blood serum | ||||
| Median (IQR) | ||||
| ACQ | 0.14 (0.11–0.19) | 0.34 (0.24–0.41) | 0.60 (0.44–0.86) | |
Statistical characteristics of the multiple logistic regression of factors potentially able to have an impact on the development of severe bronchial asthma in children
| Coeficient | Standard coefficient | p | |
|---|---|---|---|
| Constant | 0.633 | - | |
| Positive family allergic history | 0.359 | 0.383 | <0.001 |
| sVCAM-1 | 0.00063 | 0.250 | <0.001 |
| IMC CCA thickness | 0.477 | 0.160 | <0.001 |
| NO2+NO3 | 0.0147 | 0.186 | <0.001 |
Risk factors for severe asthma
| Variables | RR | 95% CI | χ2 | |
|---|---|---|---|---|
| Positive family allergic history | 7.1 | 1.991–51.025 | 6.078 | |
| Recurrent respiratory diseases | 8.9 | 2.249–35.555 | 11.206 | |
| Concomitant allergic diseases | 3.5 | 1.080–11.343 | 5.425 |
Statistical characteristics of endothelial function in children with BA in the remission period (Me [Lq; Uq])
| Children with BA | ||||
|---|---|---|---|---|
| Indices | Group 1 ( | Group 2 ( | Group 3 ( | Control group ( |
| sVCAM-1, mmol/l | 885.42 (800.57;990.47) | 1150.43 (990.37;1280.77) | 1500.18 (1300.32;1700.25) | 730.01 (690.63;790.19) |
| MW | ||||
| NO2+NO3, mcmol/l | 35.47 (32.00; 42.01) | 28.73 (25.23; 34.48) | 26.18 (22.57; 32.42) | 41.19 (38.22; 43.23) |
| MW | ||||
| FMD% | 11.27 (8.28; 13.33) | 10.12 (8.88; 11.76) | 8.33 (6.45; 8.82) | 23.33 (17.07; 27.77) |
| MW | ||||
| IMC CCA thickness, mm | 0.8 (0.8; 0.9) | 1.0 (0.8; 1.1) | 1.1 (1.1; 1.2) | 0.6 (0.5; 0.7) |
| MW | ||||