<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_pneum-2019-0014_s_006_w2aab3b7b4b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Asthma is a common disease with increasing prevalence in children and adults. The WHO estimates that annually 15 million disability-adjusted life-years are lost, and 250,000 asthma deaths are reported worldwide. Approximately, 500,000 annual hospitalizations are due to asthma (1).</p></sec><sec id="j_pneum-2019-0014_s_007_w2aab3b7b4b1b6b1aab1c16b2Aa"><h3>Aim</h3><p>In our study, we aimed to evaluate the endothelial function in children with asthma in remission and the prognosis of severe asthma.</p></sec><sec id="j_pneum-2019-0014_s_008_w2aab3b7b4b1b6b1aab1c16b3Aa"><h3>Materials and methods</h3><p>The study involved examination of 91 children, aged 6–17 years, with persistent asthma in the remission period. Indices of endothelial function (soluble vascular molecule of intercellular adhesion-1 [sVCAM-1], concentration of stable metabolites of nitric oxide in blood serum [NO<sub>2</sub> +NO<sub>3</sub> ], thickness of the intima-media complex [IMC] of the common carotid artery (CCA), and endothelium-dependent dilatation of the brachial artery [FMD%]). Statistical analyses were performed with StatSoft STATISTICA Version 8 (Tulsa, OK). To determine the relation between qualitative characteristics, the criterion χ<sup>2</sup> was used, and the procedure of multiple logistic regression analysis was performed.</p></sec><sec id="j_pneum-2019-0014_s_009_w2aab3b7b4b1b6b1aab1c16b4Aa"><h3>Results</h3><p>The endothelium parameter levels (FMD% [H = <italic>46.02], IMC [H</italic> = <italic>60.75], NO<sub>2</sub></italic> + <italic>NO<sub>3</sub> [H</italic> = <italic>40.82], and sVCAM-1 [H</italic> = <italic>76.57, p</italic> = 0.0000]) depend on the severity of the disease. The study showed that the factors that should be taken into account in prognosis of the formation of the severe course of asthma include positive family allergic history, serum sVCAM-1 and NO<sub>2</sub> + NO<sub>3</sub> levels, and the thickness of IMC CCA.</p></sec><sec id="j_pneum-2019-0014_s_010_w2aab3b7b4b1b6b1aab1c16b5Aa"><h3>Conclusions</h3><p>All the children with asthma in the remission period were found to have endothelial dysfunction. The degree of disruption of the function of the endothelium depends on the severity of the course of asthma. An algorithm for predicting the severe course of asthma in children has been developed.</p></sec></abstract>

BackgroundAsthma is a common disease with increasing prevalence in children and adults. The WHO estimates that annually 15 million disability-adjusted life-years are lost, and 250,000 asthma deaths are reported worldwide. Approximately, 500,000 annual hospitalizations are due to asthma (1).AimIn our study, we aimed to evaluate the endothelial function in children with asthma in remission and the prognosis of severe asthma.Materials and methodsThe study involved examination of 91 children, aged 6–17 years, with persistent asthma in the remission period. Indices of endothelial function (soluble vascular molecule of intercellular adhesion-1 [sVCAM-1], concentration of stable metabolites of nitric oxide in blood serum [NO2 +NO3 ], thickness of the intima-media complex [IMC] of the common carotid artery (CCA), and endothelium-dependent dilatation of the brachial artery [FMD%]). Statistical analyses were performed with StatSoft STATISTICA Version 8 (Tulsa, OK). To determine the relation between qualitative characteristics, the criterion χ2 was used, and the procedure of multiple logistic regression analysis was performed.ResultsThe endothelium parameter levels (FMD% [H = 46.02], IMC [H = 60.75], NO2 + NO3 [H = 40.82], and sVCAM-1 [H = 76.57, p = 0.0000]) depend on the severity of the disease. The study showed that the factors that should be taken into account in prognosis of the formation of the severe course of asthma include positive family allergic history, serum sVCAM-1 and NO2 + NO3 levels, and the thickness of IMC CCA.ConclusionsAll the children with asthma in the remission period were found to have endothelial dysfunction. The degree of disruption of the function of the endothelium depends on the severity of the course of asthma. An algorithm for predicting the severe course of asthma in children has been developed.

Prognosing a severe course of asthma in children following the study of endothelial function

Pneumologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Prezicerea evoluției severe a astmului la copii prin studiul funcției endoteliale

BackgroundAsthma is a common disease with increasing prevalence in children and adults. The WHO estimates that annually 15 million disability-adjusted...

Prognosing a severe course of asthma in children following the study of endothelial function

Article Category: Original Papers

Published Online: Oct 11, 2019

Page range: 68 - 74

DOI: https://doi.org/10.2478/pneum-2019-0014

Keywords
asthma, children, prognosis, endothelial dysfunction

© 2019 Amanda et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Prognosing a severe course of asthma in children following the study of endothelial function

Article Category: Original Papers

Published Online: Oct 11, 2019

Page range: 68 - 74

DOI: https://doi.org/10.2478/pneum-2019-0014

Keywordsasthma, children, prognosis, endothelial dysfunction

© 2019 Amanda et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
asthma, children, prognosis, endothelial dysfunction