<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Radiosensitization of the cancer cells by the heavy atoms of nanoparticles was the subject of some studies. But, the physical characterization to determine the weight of all interactions hasn’t been made numerically. The aim of this study was to calculate and compare the dose enhancement (DE) for different energies. The Monte Carlo simulation method was used in the current study. The influence of gold nanoparticles (GNP) size, beam quality, the GNP concentration, and dose inhomogeneity on the radiosensitization by DE was studied. A 35% increase in the photoelectric effect was observed while energy decreased from 18 MV to 300 kV. In the microscopic study which DE calculated in 30 µm from a single GNP, a 79% decreasing in DE within the first 1µm was seen and it declined to 2% in 30 µm from the GNP center. The effect was observed at small distances only. Our study revealed that the dose inhomogeneity around a nanoparticle is the main and very strong effect of DE on a macroscopic scale. In the location which 35% DE occurs most malignant cells survival will be effectively reduced. Our research indicates the need for further research.</p></abstract>

Radiosensitization of the cancer cells by the heavy atoms of nanoparticles was the subject of some studies. But, the physical characterization to determine the weight of all interactions hasn’t been made numerically. The aim of this study was to calculate and compare the dose enhancement (DE) for different energies. The Monte Carlo simulation method was used in the current study. The influence of gold nanoparticles (GNP) size, beam quality, the GNP concentration, and dose inhomogeneity on the radiosensitization by DE was studied. A 35% increase in the photoelectric effect was observed while energy decreased from 18 MV to 300 kV. In the microscopic study which DE calculated in 30 µm from a single GNP, a 79% decreasing in DE within the first 1µm was seen and it declined to 2% in 30 µm from the GNP center. The effect was observed at small distances only. Our study revealed that the dose inhomogeneity around a nanoparticle is the main and very strong effect of DE on a macroscopic scale. In the location which 35% DE occurs most malignant cells survival will be effectively reduced. Our research indicates the need for further research.

Monte Carlo characterization of the gold nanoparticles dose enhancement and estimation of the physical interactions weight in dose enhancement mechanism

Polish Journal of Medical Physics and Engineering

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Radiosensitization of the cancer cells by the heavy atoms of nanoparticles was the subject of some studies. But, the physical characterization to determine the...

Monte Carlo characterization of the gold nanoparticles dose enhancement and estimation of the physical interactions weight in dose enhancement mechanism

Published Online: Dec 24, 2020

Page range: 217 - 223

DOI: https://doi.org/10.2478/pjmpe-2020-0026

Keywords
gold nanoparticles, dose enhancement, Monte Carlo

© 2020 Mohammad Mohammadzadeh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Monte Carlo characterization of the gold nanoparticles dose enhancement and estimation of the physical interactions weight in dose enhancement mechanism

Published Online: Dec 24, 2020

Page range: 217 - 223

DOI: https://doi.org/10.2478/pjmpe-2020-0026

Keywordsgold nanoparticles, dose enhancement, Monte Carlo

© 2020 Mohammad Mohammadzadeh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
gold nanoparticles, dose enhancement, Monte Carlo