<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Comparative statistical analysis of the infiuence of processing parameters, for electrospinning (ES) and solution blow spinning (SBS) processes, on nanofibrous poly(L-lactic acid) (PLLA) material morphology and average fiber diameter was conducted in order to identify the key processing parameter for tailoring the product properties. Further, a comparative preliminary biocompatibility evaluation was performed. Based on Design of Experiment (DOE) principles, analysis of standard effects of voltage, air pressure, solution feed rate and concentration, on nanofibers average diameter was performed with the Pareto’s charts and the best fitted surface charts. Nanofibers were analyzed by scanning electron microscopy (SEM). The preliminary biocompatibility comparative tests were performed based on SEM microphotographs of CP5 cells cultured on materials derived from ES and SBS. Polymer solution concentration was identified as the key parameter infiuencing morphology and dimensions of nanofibrous mat produced from both techniques. In both cases, when polymer concentration increases the average fiber diameter increase. The preliminary biocompatibility test suggests that nanofibers produced by ES as well as SBS are suitable as the biomedical engineering scaffold material.</p></abstract>

Comparative statistical analysis of the infiuence of processing parameters, for electrospinning (ES) and solution blow spinning (SBS) processes, on nanofibrous poly(L-lactic acid) (PLLA) material morphology and average fiber diameter was conducted in order to identify the key processing parameter for tailoring the product properties. Further, a comparative preliminary biocompatibility evaluation was performed. Based on Design of Experiment (DOE) principles, analysis of standard effects of voltage, air pressure, solution feed rate and concentration, on nanofibers average diameter was performed with the Pareto’s charts and the best fitted surface charts. Nanofibers were analyzed by scanning electron microscopy (SEM). The preliminary biocompatibility comparative tests were performed based on SEM microphotographs of CP5 cells cultured on materials derived from ES and SBS. Polymer solution concentration was identified as the key parameter infiuencing morphology and dimensions of nanofibrous mat produced from both techniques. In both cases, when polymer concentration increases the average fiber diameter increase. The preliminary biocompatibility test suggests that nanofibers produced by ES as well as SBS are suitable as the biomedical engineering scaffold material.

Comparative Studies of Electrospinning and Solution Blow Spinning Processes for the Production of Nanofibrous Poly(L-Lactic Acid) Materials for Biomedical Engineering

Warsaw University of Technology, Faculty of Chemical and Process Engineering, Biotechnology and Bioprocess Engineering Division, BioMedical Engineering Laboratory, Waryńskiego 1, 00-645 Warszawa, Poland

Polish Journal of Chemical Technology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Comparative statistical analysis of the infiuence of processing parameters, for electrospinning (ES) and solution blow spinning (SBS) processes, on nanofibrous...

Comparative Studies of Electrospinning and Solution Blow Spinning Processes for the Production of Nanofibrous Poly(L-Lactic Acid) Materials for Biomedical Engineering

Published Online: Jun 26, 2014

Page range: 43 - 50

DOI: https://doi.org/10.2478/pjct-2014-0028

Keywords
electrospinning, solution blow spinning, nanofibers, biomedical engineering, design of experiments, biocompatibility

© 2014 Michal Wojasiński et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Comparative Studies of Electrospinning and Solution Blow Spinning Processes for the Production of Nanofibrous Poly(L-Lactic Acid) Materials for Biomedical Engineering

Published Online: Jun 26, 2014

Page range: 43 - 50

DOI: https://doi.org/10.2478/pjct-2014-0028

Keywordselectrospinning, solution blow spinning, nanofibers, biomedical engineering, design of experiments, biocompatibility

© 2014 Michal Wojasiński et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
electrospinning, solution blow spinning, nanofibers, biomedical engineering, design of experiments, biocompatibility