<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The aim of this experimental work was the enhancement of water solubility of the lipid lowering atorvastatin, by embedding it in polymer based micro sized fibers obtained by electrospinning. We prepared a polyvinylpyrrolidone (Kollidon 90F<sup>®</sup>) dispersion and added the active substance. By setting the experimental parameters we obtained four different microfibers containing atorvastatin, and one without the drug. The pH, viscosity and conductivity of the dispersions have been measured. The drug content and dissolution of atorvastatin had been studied by capillary electrophoresis. The size and thermal behavior of the fibers was determined. The parameters of the microfibers are influenced by the experimental parameters of electrospinning. The micro-method for dissolution showed a twofold solubility enhancement.</p></abstract>

The aim of this experimental work was the enhancement of water solubility of the lipid lowering atorvastatin, by embedding it in polymer based micro sized fibers obtained by electrospinning. We prepared a polyvinylpyrrolidone (Kollidon 90F®) dispersion and added the active substance. By setting the experimental parameters we obtained four different microfibers containing atorvastatin, and one without the drug. The pH, viscosity and conductivity of the dispersions have been measured. The drug content and dissolution of atorvastatin had been studied by capillary electrophoresis. The size and thermal behavior of the fibers was determined. The parameters of the microfibers are influenced by the experimental parameters of electrospinning. The micro-method for dissolution showed a twofold solubility enhancement.

Solubility enhancement of atorvastatin by embedding in micro sized carrier

University of Medicine, Pharmacy, Sciences and Technology of Targu Mureş

Faculty of Pharmacy, Pharmaceutical Technology and cosmetology discipline

Faculty of Pharmacy, Pharmaceutical chemistry discipline

Faculty of Pharmacy, Pharmaceutical industry and management discipline

Bulletin of Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Solubility enhancement of atorvastatin by embedding in micro sized carrier"}

The aim of this experimental work was the enhancement of water solubility of the lipid lowering atorvastatin, by embedding it in polymer based micro sized...

Solubility enhancement of atorvastatin by embedding in micro sized carrier

Published Online: Feb 13, 2020

Page range: 47 - 52

Received: Feb 28, 2019

Accepted: Apr 02, 2019

DOI: https://doi.org/10.2478/orvtudert-2019-0004

Keywords
atorvastatin, microfiber, Kollidon 90F

© 2019 Rédai Emőke et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Solubility enhancement of atorvastatin by embedding in micro sized carrier

Published Online: Feb 13, 2020

Page range: 47 - 52

Received: Feb 28, 2019

Accepted: Apr 02, 2019

DOI: https://doi.org/10.2478/orvtudert-2019-0004

Keywordsatorvastatin, microfiber, Kollidon 90F

© 2019 Rédai Emőke et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
atorvastatin, microfiber, Kollidon 90F