Simvastatin-induced changes in the leukocytic system of porcine bone marrow
Published Online: Oct 23, 2018
Page range: 329 - 333
Received: May 14, 2018
Accepted: Aug 28, 2018
DOI: https://doi.org/10.2478/jvetres-2018-0034
Keywords
© 2018 A. Snarska et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Fig. 1
Fig. 2
The average number (mean ±SEM) of leukocytic system cells as count per 1,000 bone marrow cells of all types under physiological conditions (control group) and after simvastatin administration (experimental group)
| Cell type | Day of experiment | Control group | Experimental group |
|---|---|---|---|
| 0 | 0.67 ±0.4 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 0.53 ±1.8 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Myeloblasts | 28 | 0.59 ±0.31 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 5.32 ±1.6 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 56 | 0.48 ±0.29 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 4.37 ±1.59 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 0 | 0.66 ±0.23 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 0.64 ±2.8 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Promyelocytes, | 28 | 0.69 ±0.23 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 9.62 ±4.2 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 56 | 0.54 ±0.34 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 9.31 ±3.0 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 0 | 2.18 ±0.69 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 2.31 ±5.1 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Neutrophilic myelocytes | 28 | 2.13 ±0.75 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 14.82 ±4.61 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 56 | 2.11 ±0.76 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 15.18 ±5.23 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 0 | 7.76 ±3.28 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 8.62 ±8.4 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Neutrophilic metamyelocytes | 28 | 8.41 ±2.36 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 32.54 ±6.21 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 56 | 8.28 ±2.27 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 38.68 ±7.38 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 0 | 56.95 ±11.39 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 66.87 ±20.7 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Band neutrophils | 28 | 54.75 ±16.40 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 109.81 ±21.77 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 56 | 68.1 ±15.84 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 112.81 ±2.48 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 0 | 156.31 ±48.91 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 143.25 ±40.65 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Neutrophilic granulocytes | 28 | 167.0 ±36.34 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 235.38 ±56.1 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 56 | 139.43 ±31.62 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 235.27 ±46.09 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 0 | 0.45 ±0.35 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 0.39 ±1.2 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Eosinophilic myelocytes | 28 | 0.36 ±0.48 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 4.21 ±1.9 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 56 | 0.32 ±0.21 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 4.43 ±1.86 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 0 | 0.76 ±0.34 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 0.62 ±1.74 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Eosinophilic metamyelocytes | 28 | 0.85 ±0.86 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 6.24 ±2.34 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 56 | 0.53 ±0.28 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 6.56 ±1.90 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 0 | 5.46 ±2.75 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 5.43 ±4.0 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Band eosinophils | 28 | 6.50 ±2.66 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 8.42 ±2.40 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 56 | 5.43 ±1.0 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 8.52.4 ±4.03 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 0 | 16.95 ±6.67 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 15.18 ±8.5 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Eosinophilic granulocytes | 28 | 16.25 ±6.59 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 27.18 ±9.6 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 56 | 15.74 ±6.66 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 27.18 ±9.57 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Basophilic myelocytes | 0 | 0.51 ±0.09 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 0.51 ±1.6 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 28 | 0.45 ±0.1 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 1.65 ±2.3 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 56 | 0.75 ±0.96 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 1.04 ±1.92 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Basophilic metamyelocytes | 0 | 1.4 ±0.23 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 1.57 ±1.5 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 28 | 1.56 ±0.24 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 2.68 ±2.8 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 56 | 1.43 ±1.23 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 2.34 ±1.82 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Band basophiles | 0 | 1.96 ±0.34 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 1.62 ±1.6 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 28 | 1.24 ±0.31 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 1.68 ±1.5 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 56 | 1.43 ±1.31 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 1.56 ±1.59 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| Basophilic granulocytes | 0 | 1.49 ±3.24 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 1.54 ±1.4 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |
| 28 | 2.22 ±5.21 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 1.75 ±1.3 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | |
| 56 | 1.26 ± 3.69 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row | 1.75 ±1.29 Statistically significant data (P ≤ 0.05) in particular cell types are marked by different letters in the same row andunsignificant data are marked by the same letters in the same row |