<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_jvetres-2018-0034_s_005_w2aab3b7b1b1b6b1aab1c16b1Aa"><h3>Introduction</h3><p>Simvastatin is a substance which is commonly used as a medicine to reduce cholesterol level. Unfortunately, it shows numerous side effects. Simvastatin affects various internal organs, and among other detriments to health may cause persistent muscle weakness, osteolytic processes, headaches, and rashes. Until now knowledge of the influence of simvastatin on bone marrow cells has been rather scant and fragmentary.</p></sec><sec id="j_jvetres-2018-0034_s_006_w2aab3b7b1b1b6b1aab1c16b2Aa"><h3>Material and Methods</h3><p>During this experiment the numbers of all types of cells in the leukocytic system of porcine bone marrow were evaluated after 28 and 56 days of oral administration of simvastatin at a dose of 40 mg/day/animal.</p></sec><sec id="j_jvetres-2018-0034_s_007_w2aab3b7b1b1b6b1aab1c16b3Aa"><h3>Results</h3><p>Simvastatin caused an increase in the number of all types of cells in the leukocytic system, and the most visible fluctuations concerned promyelocytes.</p></sec><sec id="j_jvetres-2018-0034_s_008_w2aab3b7b1b1b6b1aab1c16b4Aa"><h3>Conclusion</h3><p>Observations obtained during the present study indicated that the results of the action of simvastatin on porcine bone marrow differ from those observed in other mammal species, including human. This may be due to various metabolic pathways within the bone marrow in the particular species, but the exact mechanisms of these actions are unknown at the present time.</p></sec></abstract>

IntroductionSimvastatin is a substance which is commonly used as a medicine to reduce cholesterol level. Unfortunately, it shows numerous side effects. Simvastatin affects various internal organs, and among other detriments to health may cause persistent muscle weakness, osteolytic processes, headaches, and rashes. Until now knowledge of the influence of simvastatin on bone marrow cells has been rather scant and fragmentary.Material and MethodsDuring this experiment the numbers of all types of cells in the leukocytic system of porcine bone marrow were evaluated after 28 and 56 days of oral administration of simvastatin at a dose of 40 mg/day/animal.ResultsSimvastatin caused an increase in the number of all types of cells in the leukocytic system, and the most visible fluctuations concerned promyelocytes.ConclusionObservations obtained during the present study indicated that the results of the action of simvastatin on porcine bone marrow differ from those observed in other mammal species, including human. This may be due to various metabolic pathways within the bone marrow in the particular species, but the exact mechanisms of these actions are unknown at the present time.

Simvastatin-induced changes in the leukocytic system of porcine bone marrow

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Simvastatin-induced changes in the leukocytic system of porcine bone marrow"}

IntroductionSimvastatin is a substance which is commonly used as a medicine to reduce cholesterol level. Unfortunately, it shows numerous side effects....

Simvastatin-induced changes in the leukocytic system of porcine bone marrow

Published Online: Oct 23, 2018

Page range: 329 - 333

Received: May 14, 2018

Accepted: Aug 28, 2018

DOI: https://doi.org/10.2478/jvetres-2018-0034

Keywords
pig, statins, bone marrow, leukocytic system

© 2018 A. Snarska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Simvastatin-induced changes in the leukocytic system of porcine bone marrow

Published Online: Oct 23, 2018

Page range: 329 - 333

Received: May 14, 2018

Accepted: Aug 28, 2018

DOI: https://doi.org/10.2478/jvetres-2018-0034

Keywordspig, statins, bone marrow, leukocytic system

© 2018 A. Snarska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
pig, statins, bone marrow, leukocytic system