<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Biofilms can form on living or inert surfaces and prevail in natural, industrial, and hospital environments. They are made of bacteria organized in a coordinated functional community. Biofilms do not respond to antibiotic treatment due to multiple mechanisms of tolerance and resistance. If bacteria are coordinated in a biofilm form, they are significantly less susceptible to antibiotics, thus making the therapeutic approach difficult. The possibility of using drugs aimed at inhibiting the formation of biofilms in combination with current antibiotics is a therapeutic approach with a major potential for this type of persistent bacterial infection. This bibliographic study aims to present the main compounds that act by inhibiting or destroying the bacterial biofilm.</p></abstract>

Biofilms can form on living or inert surfaces and prevail in natural, industrial, and hospital environments. They are made of bacteria organized in a coordinated functional community. Biofilms do not respond to antibiotic treatment due to multiple mechanisms of tolerance and resistance. If bacteria are coordinated in a biofilm form, they are significantly less susceptible to antibiotics, thus making the therapeutic approach difficult. The possibility of using drugs aimed at inhibiting the formation of biofilms in combination with current antibiotics is a therapeutic approach with a major potential for this type of persistent bacterial infection. This bibliographic study aims to present the main compounds that act by inhibiting or destroying the bacterial biofilm.

Biofilm Inhibition: Compounds with Antibacterial Effects

Department of Orthopedics and Traumatology

University of Medicine, Pharmacy, Science and Technology

Journal of Interdisciplinary Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Biofilm Inhibition: Compounds with Antibacterial Effects"}

Biofilms can form on living or inert surfaces and prevail in natural, industrial, and hospital environments. They are made of bacteria organized in a...

Biofilm Inhibition: Compounds with Antibacterial Effects

Published Online: Feb 01, 2019

Page range: 234 - 238

Received: Jul 31, 2018

Accepted: Sep 17, 2018

DOI: https://doi.org/10.2478/jim-2018-0042

Keywords
biofilm inhibition, bacterial infection, polysaccharides

© 2018 Andrei-Marian Feier et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Biofilm Inhibition: Compounds with Antibacterial Effects

Published Online: Feb 01, 2019

Page range: 234 - 238

Received: Jul 31, 2018

Accepted: Sep 17, 2018

DOI: https://doi.org/10.2478/jim-2018-0042

Keywordsbiofilm inhibition, bacterial infection, polysaccharides

© 2018 Andrei-Marian Feier et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
biofilm inhibition, bacterial infection, polysaccharides