<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_jccm-2020-0018_s_006_w2aab3b7c30b1b6b1aab1c15b1Aa"><h3>Introduction</h3><p>Peptic mucosal damage induced by acute stress is a serious cause of morbidity and mortality in critically ill patients. The study aimed to investigate the protective, antioxidant and anti-inflammatory effects of pretreatment with Chios mastic gum (CMG), a traditionally consumed herbal resin naturally deriving from the trunk of Pistacia Lentiscus var. Chia compared to Omeprazole, a standard medication used in the prevention and treatment of gastritis, against the effects of cold restraint stress (CRS) in rat gastric and colonic mucosa.</p></sec><sec id="j_jccm-2020-0018_s_007_w2aab3b7c30b1b6b1aab1c15b2Aa"><h3>Methods</h3><p>Twenty-one male Wistar rats were randomly assigned to three groups: Control (C), Omeprazole (O), and CMG (M), according to the pre-treatment regime, and were subjected to CRS at 4<sup>0</sup>C for 3 hours. The gastric and colonic mucosal lesions were histologically assessed. ELISA measured blood concentrations of TNF-α, IL-1β, peroxidase, superoxide dismutase (SOD) and total antioxidant capacity (TEAC).</p></sec><sec id="j_jccm-2020-0018_s_008_w2aab3b7c30b1b6b1aab1c15b3Aa"><h3>Results</h3><p>In both groups, O and M, gastric mucosal hyperemia, haemorrhagic infiltration and mucosal oedema, as well as colonic mucosal hyperaemia and haemorrhagic infiltration were significantly reduced compared to the controls (p&lt;0.05). No significant differences were observed between Groups O and M. TNF-α levels were significantly lower in group M compared to Group O (p=0.013). IL-1β levels were significantly depressed in groups M and O compared to control (p≤ 0.001). The activity of both peroxidase and SOD enzymes decreased in group M compared to group O (p= 0.043 and p=0.047 respectively) and the control (p=0.018 and p&lt; 0.001 respectively).</p></sec><sec id="j_jccm-2020-0018_s_009_w2aab3b7c30b1b6b1aab1c15b4Aa"><h3>Conclusions</h3><p>The natural Chios mastic gum is a promising nutritional supplement with protective properties to the peptic mucosa against CRS, exerting anti-inflammatory and antioxidant effects.</p></sec></abstract>

IntroductionPeptic mucosal damage induced by acute stress is a serious cause of morbidity and mortality in critically ill patients. The study aimed to investigate the protective, antioxidant and anti-inflammatory effects of pretreatment with Chios mastic gum (CMG), a traditionally consumed herbal resin naturally deriving from the trunk of Pistacia Lentiscus var. Chia compared to Omeprazole, a standard medication used in the prevention and treatment of gastritis, against the effects of cold restraint stress (CRS) in rat gastric and colonic mucosa.MethodsTwenty-one male Wistar rats were randomly assigned to three groups: Control (C), Omeprazole (O), and CMG (M), according to the pre-treatment regime, and were subjected to CRS at 40C for 3 hours. The gastric and colonic mucosal lesions were histologically assessed. ELISA measured blood concentrations of TNF-α, IL-1β, peroxidase, superoxide dismutase (SOD) and total antioxidant capacity (TEAC).ResultsIn both groups, O and M, gastric mucosal hyperemia, haemorrhagic infiltration and mucosal oedema, as well as colonic mucosal hyperaemia and haemorrhagic infiltration were significantly reduced compared to the controls (p<0.05). No significant differences were observed between Groups O and M. TNF-α levels were significantly lower in group M compared to Group O (p=0.013). IL-1β levels were significantly depressed in groups M and O compared to control (p≤ 0.001). The activity of both peroxidase and SOD enzymes decreased in group M compared to group O (p= 0.043 and p=0.047 respectively) and the control (p=0.018 and p< 0.001 respectively).ConclusionsThe natural Chios mastic gum is a promising nutritional supplement with protective properties to the peptic mucosa against CRS, exerting anti-inflammatory and antioxidant effects.

The Use of Pistacia Lentiscus Chia Resin versus Omeprazole in Protecting Male Rats Peptic Mucosa against Cold Restraint Stress

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

IntroductionPeptic mucosal damage induced by acute stress is a serious cause of morbidity and mortality in critically ill patients. The study aimed to...

The Use of Pistacia Lentiscus Chia Resin versus Omeprazole in Protecting Male Rats Peptic Mucosa against Cold Restraint Stress

Article Category: Research article

Published Online: May 06, 2020

Page range: 100 - 110

Received: Feb 11, 2020

Accepted: Apr 14, 2020

DOI: https://doi.org/10.2478/jccm-2020-0018

Keywords
cold restraint stress, colitis, gastric ulcer, oxidative stress, Pistacia Lentiscus Chia, Omeprazole

© 2020 Despoina Kakagia, Apostolos Papalois, Maria Lambropoulou, Fotini Papachristou, Gregory Trypsiannis, Constantinos Anagnostopoulos, Mike Pitiakoudis, Alexandra Tsaroucha, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The Use of Pistacia Lentiscus Chia Resin versus Omeprazole in Protecting Male Rats Peptic Mucosa against Cold Restraint Stress

Article Category: Research article

Published Online: May 06, 2020

Page range: 100 - 110

Received: Feb 11, 2020

Accepted: Apr 14, 2020

DOI: https://doi.org/10.2478/jccm-2020-0018

Keywordscold restraint stress, colitis, gastric ulcer, oxidative stress, Pistacia Lentiscus Chia, Omeprazole

© 2020 Despoina Kakagia, Apostolos Papalois, Maria Lambropoulou, Fotini Papachristou, Gregory Trypsiannis, Constantinos Anagnostopoulos, Mike Pitiakoudis, Alexandra Tsaroucha, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
cold restraint stress, colitis, gastric ulcer, oxidative stress, Pistacia Lentiscus Chia, Omeprazole