<abstract xmlns="http://www.w3.org/1999/xhtml">In recent years, a new form of medicine has become increasingly significant, namely, personalised medicine (PM). PM is a form of care in which treatment is tailored for an individual patient.PM is about using multiple data sets to create a digital human mapping. A person’s biological traits are determined by the interactions of hundreds of genes and gene networks, as well as external factors such as diet and exercise. Combining and then investigating these multiple databases with powerful statistical tools, allows a new understanding of how genetic intricacy drives health and disease and so leads to a closer personalised medical approach that targets each individual’s unique genetic make-up.Sepsis is a systemic inflammatory response to infection, ranging from systemic inflammatory response syndrome (SIRS) to septic shock and multiple organ dysfunction syndromes (MODS). Sepsis is the most common cause of death in intensive care patients. Treatments in an ICU may need to be adapted to the continuous and rapid changes of the disease, making it challenging to identify a single target. PM is thus seen as the future of sepsis treatment in the ICU.The fact that individual patients respond differently to treatment should be regarded as a starting point in the approach to providing treatment. The disease itself comes secondary to this concept.</abstract>

In recent years, a new form of medicine has become increasingly significant, namely, personalised medicine (PM). PM is a form of care in which treatment is tailored for an individual patient.PM is about using multiple data sets to create a digital human mapping. A person’s biological traits are determined by the interactions of hundreds of genes and gene networks, as well as external factors such as diet and exercise. Combining and then investigating these multiple databases with powerful statistical tools, allows a new understanding of how genetic intricacy drives health and disease and so leads to a closer personalised medical approach that targets each individual’s unique genetic make-up.Sepsis is a systemic inflammatory response to infection, ranging from systemic inflammatory response syndrome (SIRS) to septic shock and multiple organ dysfunction syndromes (MODS). Sepsis is the most common cause of death in intensive care patients. Treatments in an ICU may need to be adapted to the continuous and rapid changes of the disease, making it challenging to identify a single target. PM is thus seen as the future of sepsis treatment in the ICU.The fact that individual patients respond differently to treatment should be regarded as a starting point in the approach to providing treatment. The disease itself comes secondary to this concept.

Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View"}

In recent years, a new form of medicine has become increasingly significant, namely, personalised medicine (PM). PM is a form of care in which treatment is...

Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View

Article Category: Review

Published Online: Aug 09, 2019

Page range: 90 - 96

Received: Apr 14, 2019

Accepted: Jul 29, 2019

DOI: https://doi.org/10.2478/jccm-2019-0017

Keywords
precision medicine, intensive care, sepsis, multiple datasets, genome

© 2019 Alexandra Lazăr, Anca Meda Georgescu, Alexander Vitin, Leonard Azamfirei, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View

Article Category: Review

Published Online: Aug 09, 2019

Page range: 90 - 96

Received: Apr 14, 2019

Accepted: Jul 29, 2019

DOI: https://doi.org/10.2478/jccm-2019-0017

Keywordsprecision medicine, intensive care, sepsis, multiple datasets, genome

© 2019 Alexandra Lazăr, Anca Meda Georgescu, Alexander Vitin, Leonard Azamfirei, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
precision medicine, intensive care, sepsis, multiple datasets, genome