Royal Jelly: Chemistry, Storage and Bioactivities

Abdel-Hafez, S. M. N., Rifaai, R. A., & Abdelzaher, W. Y. (2017). Possible protective effect of royal jelly against cyclophosphamide induced prostatic damage in male albino rats; a biochemical, histological and immuno-histo-chemical study. Biomedicine & Pharmacotherapy, 90, 15-23. DOI: 10.1016/j.biopha.2017.03.02010.1016/j.biopha.2017.03.02028340377Open DOISearch in Google Scholar

Abdelatif, M., Yakoot, M., & Etmaan, M. (2008). Safety and efficacy of a new honey ointment on diabetic foot ulcers: a prospective pilot study. Journal of Wound Care, 1(3), 108-110. DOI: 10.12968/jowc.2008.17.3.2866710.12968/jowc.2008.17.3.2866718376651Search in Google Scholar

Abdelnur, P. V., Abe, S., Cunha, I. B. S., Lima-Pallone, J. A., Godoy, T., Eberlin, M. N., Catharino, R. R. (2011). Metabolic fingerprinting of royal jelly: characterization and proof of authenticity. Quality Assurance and Safety of Crops & Foods, 3(4), 185-190. DOI: org/10.1111/j.1757-837X.2011.00112.x10.1111/j.1757-837X.2011.00112.xOpen DOISearch in Google Scholar

Alcay, S., Toker, M. B., Onder, N. T., & Gokce, E. (2017). Royal jelly supplemented soybean lecithin-based extenders improve post-thaw quality and incubation resilience of goat spermatozoa. Cryobiology, 74, 81-85. DOI: org/10.1016/j.cryobiol.2016.11.01110.1016/j.cryobiol.2016.11.01127908685Open DOISearch in Google Scholar

Al-Masri, A. (2011). The royal jelly, honeybee kingdom and its derivation. In Bartolome, J A A L F M P (ed.) Arabic Book House Publishers. 291-300.Search in Google Scholar

Ashry, K., & Elkady, A. A. (2014). Royal Jelly Modulates Hepatotoxic Effect of Rats Treated with Cisplatin. Arab Journal of Nuclear Science and Applications, 47(1), 172-180.Search in Google Scholar

Bărnuţiu, L. I., Mărghitaş, L. A., Dezmirean, D. S., Mihai, C. M., Bobi, O. (2011). Chemical composition and antimicrobial activity of Royal Jelly. Animal Science and Biotechnologies, 44(2), 109-117.Search in Google Scholar

Balkanska, R., Zhelyazkova, I., & Ignatova, M. (2012). Physico-chemical quality characteristics of royal jelly from three regions of Bulgaria. Agricultural Science and Technology, 4(3), 302-305.Search in Google Scholar

Balkanska, R., & Kashamov, B. (2011). Composition and physico-chemical properties of lyophilized Royal jelly. Bee Science, 11(4), 114-117.Search in Google Scholar

Batchelder, T. (2002). Royal Jelly: A novel mechanism of liver enhancement from a traditional bee product. Townsend Letter for Doctors and Patients, 233, 46-48.Search in Google Scholar

Bogdanov, S. (2014). Royal Jelly, Bee Brood: Composition, Health, Medicine. Bee Product Science. Available from: http://www.bee-hexagon.net/royal-jelly/harvest-composition-quality.Search in Google Scholar

Boselli, E., Caboni, M. F., Sabatini, A. G., Marcazzan, G. L., Lercker, G. (2003). Determination and changes of free amino acids in royal jelly during storage. Apidologie, 34, 129-137. DOI: 10.1051/apido:200301110.1051/apido:2003011Open DOISearch in Google Scholar

Boukraâ, L., Meslem, A., Benhanifia, M., & Hammoudi, S.M. (2009). Synergistic effect of starch and Royal Jelly against Staphylococcus aureus and Escherichia coli. Journal of Alternative and Complementary Medicine, 15(7), 755-757. DOI: 10.1089/acm.2008.048310.1089/acm.2008.048319534615Open DOISearch in Google Scholar

Boukraâ, L., Niar, A., Benbarek, H., & Benhanifia, M. (2008). Additive action of royal jelly and honey against Staphylococcus aureus. Journal of Medicinal Food, 11(1), 190-192. DOI: 10.1089/jmf.2007.567.10.1089/jmf.2007.56718361756Open DOISearch in Google Scholar

Burimistrova, L., Agafonova, A., Budnikova, N., & Haritonova, M. (2008). Methods for the stabilisation of biologically active components royal jelly (Russian). Apitherapy today, Ribnoe. 175-182.Search in Google Scholar

Carvalho, V., Silveira, V., Do-Prado, R., & Carvalho, Y. (2011). Effect of estrogen therapy, soy isoflavones, and the combination therapy on the submandibular gland of ovariectomized rats. Pathology - Research and Practice, 207(5), 300-305. DOI: 10.1016/j.prp.2011.01.002. Epub 2011 Apr 21.10.1016/j.prp.2011.01.002.Epub2011Apr21Open DOISearch in Google Scholar

Cemek, M., Aymelek, F., Buyukokuroglu, M. E., Karaca, T., Buyukben, A., Yilmaz, F. (2010). Protective potential of royal jelly against carbon tetrachloride induced toxicity and changes in the serum sialic acid levels. Food and Chemical Toxicology, 48(10), 2827-2832. DOI: 10.1016/j.fct.2010.07.013. Epub 2010 Jul 15.10.1016/j.fct.2010.07.01320637822Search in Google Scholar

Chan, Q.W.T., Melathopoulos, A.P., Pernal, S.F., & Foster, L. J. (2009). The innate immune and systemic response in honeybees to a bacterial pathogen, Paenibacillus larvae. BMC Genomics, 10(387), 175-188. DOI: org/10.1186/1471-2164-10-387.Search in Google Scholar

Cushnie, T. P. T., & Lamb, A. J. (2005). Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss. Journal of Ethnopharmacology, 101, 243-248.10.1016/j.jep.2005.04.01415985350Search in Google Scholar

Drapeau, M. D., Albert, S., Kucharski, R., Prusko, C., Maleszka, R. (2006). Evolution of the yellow/major royal jelly protein family and the emergence of social behavior in honeybees. Genome Research, 16, 1385-1394. DOI: 10.1101/gr.5012006.10.1101/gr.5012006162664017065613Open DOISearch in Google Scholar

Dinkov, D., & Stoyanchev, T. (2014). Antibacterial effect of Royal gelly, mix from Royal jelly and rape honey (1:100), rape and oak honeydew honeys against Escherichia coli (ATCC 25922). African Journal of Pharmacy and Pharmacology, 8(11), 321-326. DOI: 10.5897/AJPP2012.60110.5897/AJPP2012.601Open DOISearch in Google Scholar

Drijfhout, F. P., Kochansky, J., Lin, S., & Calderone, N. (2005). Composition of honeybee royal jelly as detterents of the parasiticv arroa Mite, Varroa destructor. Journal of Chemical Ecology, 31(8), 1747-64. DOI: 10.1007/s10886-005-5925-610.1007/s10886-005-5925-616222806Search in Google Scholar

Dzopalic, T., Vucevic, D., Tomic, S., Djokic, J., Chinou, I., Colic, M. (2011). 3-10-Dihydroxy-decanoic acid, isolated from royal jelly, stimulates Th1 polarising capability of human monocyte-derived dendritic cells. Food Chemistry, 126(3), 1211-1217. DOI: org/10.1016/j.foodchem.2010.12.00410.1016/j.foodchem.2010.12.004Open DOISearch in Google Scholar

El-Gayar, M. H., Aboshanab, K. M., Aboulwafa, M. M., & Hassouna, N. A. (2016). Antivirulence and wound healing effects of royal jelly and garlic extract for the control of MRSA skin infections. Wound Medicine, 13, 18-27. DOI: org/10.1016/j.wndm.2016.05.00410.1016/j.wndm.2016.05.004Open DOISearch in Google Scholar

Eshtiyaghi, M., Deldar, H., Ansari, Z., & Shohreh, B. (2016). Royal jelly may improve the metabolism of glucose and redox state of ovine oocytes matured in vitro, and embryonic development following in vitro fertilization. Theriogenology, 86(9), 2210-2221. DOI: 10.1016/j.theriogenology.2016.07.01910.1016/j.theriogenology.2016.07.01927568457Open DOISearch in Google Scholar

Fratini, F., Cilia, C., Mancini, S., & Felicioli, A. (2016). Royal Jelly: An ancient remedy with remarkable antibacterial properties. Microbiological Research, 192, 130-141. https://doi.org/10.1016/j.micres.2016.06.00710.1016/j.micres.2016.06.00727664731Open DOISearch in Google Scholar

Fontana, R., Maria, A., Mendesb, B., Monson de Souza, K., Konno, L´ılian Mari M. César, Osmar, M., Palma, M.S. (2004). Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera). Peptides, 25, 919-928.10.1016/j.peptides.2004.03.01615203237Search in Google Scholar

Furukawa, S. (2008). Stimulatory effects of royal jelly on the generation of neuronal and glial cells-expectation of protection against some neurological disorders. Foods and Food Ingredients Journal of Japan, 213(7), 620-626.Search in Google Scholar

Galaly, S. R., Abdella, E. M., Mohammed, H. M., & Khadrawy, S. M. (2014). Effects of royal jelly on genotoxicity and nephrotoxicity induced by valproic acid in albino mice. Beni-Suef University Journal of Basic and Applied Sciences, 3, 1-15. DOI: org/10.1016/j.bjbas.2014.02.00110.1016/j.bjbas.2014.02.001Open DOISearch in Google Scholar

García, M. C., Finola, M. S., & Marioli, J. M. (2010). Antibacterial activity of royal jelly against bacteria capable of infecting cutaneous wounds. Journal of ApiProduct and ApiMedical Science, 2(3), 93-99. DOI: 10.3896/IBRA.4.02.3.0210.3896/IBRA.4.02.3.02Open DOISearch in Google Scholar

Garcia-Amoedo, L.H., Bicudo, L., & Almeida-Muradian, L.B. (2002). Comparacao de metodologias para a determinacao de umidade em geleia real. Quim Nova, 25, 676-679. DOI: org/10.1590/S0100-4042200200040002410.1590/S0100-40422002000400024Open DOISearch in Google Scholar

Gimenez-Diaz, C., Emsen, B., Emsen, E., Kutluca, M., Koycegiz, F. (2012). Improved reproductive response of sheep in intrauterine insemination program with the use of royal jelly. African Journal of Biotechnology, 11(61), 12518-12521. DOI: org/10.5897/AJB12.20010.5897/AJB12.200Open DOISearch in Google Scholar

Hattori, N., Nomoto, H., Fukumitsu, H., Mishima, S., Fukurawa, S. (2010). AMP N(1)-oxide, a unique compound of royal jelly, induces neurite outgrowth from PC12 cells via signaling by protein kinase A independent of that by mitogen-activated protein kinase. Evidence-based complementary and alternative medicine, 7(1), 63-68. DOI: 10.1093/ecam/nem14610.1093/ecam/nem146281637918955270Open DOISearch in Google Scholar

Hattori, N., Ohta, S., Sakamoto, T., Mishima, S., Furukawa, S. (2009). Royal jelly facilitates restoration of the cognitive ability in trimethyltin-intoxicated mice. Evidence-Based Complementary and Alternative Medicine, 63(1), 57-64. DOI: 10.1093/ecam/nep02910.1093/ecam/nep029309471019376837Open DOISearch in Google Scholar

Henrique, L., Amodeo, G., Bicudo, L., & Muradian, A. (2003). Determination of trans-10-hydroxy-2-Decenoic acid (10-HDA) in royal jelly from Sao Paulo State, Brazil. Ciência e Tecnologia de Alimentos, 23, 62-65.10.1590/S0101-20612003000400012Search in Google Scholar

Henshaw, F. R., Twigg, S. M., & McLennan, S. (2014). What’s the buzz: bee products and their potential value in diabetic wound healing. The Journal of Diabetic Foot Complications, 6(2), 24-39.Search in Google Scholar

Ibrahim, A.A. El-M. (2014). Immunomodulatory effects of royal jelly on aorta CD3, CD68 and eNOS expression in hypercholesterolaemic rats. The Journal of Basic & Applied Zoology, 67(4), 140-148. https://doi.org/10.1016/j.jobaz.2014.08.00610.1016/j.jobaz.2014.08.006Open DOISearch in Google Scholar

Isidorova, V. A., Czyzewska, U., Isidorovab, A. G., & Bakier, S. (2009). Gas chromatographic and mass spectrometric characterization of the organic acids extracted from some preparations containing lyophilized royal jelly. Journal of Chromatography B, 877, 3776-3780. DOI: org/10.1016/j.jchromb.2009.09.01610.1016/j.jchromb.2009.09.01619767252Open DOISearch in Google Scholar

Isidorov, V. A., Czyzewska, U., Jankowska, E., & Bakier, S. (2011). Determination of royal jelly acids in honey. Food Chemistry, 124, 387-391. DOI: org/10.1016/j.foodchem.2010.06.04410.1016/j.foodchem.2010.06.044Open DOISearch in Google Scholar

Isidorov, V. A., Bakier, S., & Grzech, I. (2012). Gas chromatographic-mass spectrometric investigation of volatile and extractable compounds of crude royal jelly. Journal of Chromatography B, 885-886, 109-116. DOI: 10.1016/j.jchromb.2011.12.02510.1016/j.jchromb.2011.12.02522245368Open DOISearch in Google Scholar

Ito, S., Nitta, J., Fukumitsu, H., Soumiya, H., Ikeno, K., Nakamura, T., Furukawa, S. (2011). Antidepressant-like activity of 10-hydroxy-trans-2-decenoic acid, a unique unsaturated fatty acid of royal jelly, in stress-inducible depression-like mouse model. Evidence-based complementary and alternative medicine, Article ID 139140, 1-6. DOI: org/10.1155/2012/139140Search in Google Scholar

Izuta, H., Narahara, Y., Shimazawa, M., Mishima, S., Kondo, S., Hara, H. (2009). 1, 1-Diphenyl-2-picrylhydrazyl Radical Scavenging Activity of Bee Products and Their Constituents Determined by ESR. Biological and Pharmaceutical Bulletin, 32(12), 1947-1951.10.1248/bpb.32.194719952409Search in Google Scholar

Jamnik, P., Raspor, P., & Javornik, B. (2012). A Proteomic Approach for Investigation of Bee Products: Royal Jelly, Propolis and Honey. Food Technology and Biotechnology, 50(3), 270-274.Search in Google Scholar

Joksimović, A., Stanković, D., & Joksimović, I. (2009). Royal jelly as a supplement for young football players. Sport Science, 1, 62-67.Search in Google Scholar

Kanbur, M., Erasian, G., Beyaz, L., Silici, S., Liman, B.C., Altinordulu, S., Atasever, A. (2009). The effects of royal jelly on liver damage induced by paracetamol in mice. Experimental and Toxicologic Pathology, 61(2), 123-132. DOI: 10.1016/j.etp.2008.06.00310.1016/j.etp.2008.06.00318693095Open DOISearch in Google Scholar

Kamakura, M., Mitani, N., Fukuda, T., & Fukushima, M. (2001). Antifatigue effect of fresh royal jelly in mice. Journal of Nutritional Science and Vitaminology, 47(6), 394-401. PMID: 11922114.10.3177/jnsv.47.39411922114Search in Google Scholar

Karadeniz, A., Simsek, N., Karakus, E., Yildirim, S., Kara, A., Can, I., Kisa, F., Emre, H., Turkeli, M. (2011). Royal Jelly Modulates Oxidative Stress and Apoptosis in Liver and Kidneys of Rats Treated with Cisplatin. Oxidative Medicine and Cellular Longevity, Article ID 981793, 1-10. DOI: org/10.1155/2011/98179310.1155/2011/981793316657921904651Search in Google Scholar

Kazu-Michi, S., Yoichiro, I., Hiroe, M., Yayoi, Y., Yukio, N., Shozo, O., Yoko, A., Takeshi, M., Satoshi, M. (2008). Estrogenic Activities of Fatty Acids and a Sterol Isolated from Royal Jelly. Evidence-Based Complementary and Alternative Medicine, 5(3), 295-302. DOI: 10.1093/ecam/nem03610.1093/ecam/nem036252937818830443Open DOISearch in Google Scholar

Kim, J., Kim, Y., Yun, H., Park, H., Kim, S.Y., Lee, K. G., Han, S.M., Cho, Y. (2010). Royal jelly enhances migration of human dermal fibroblasts and alters the levels of cholesterol and sphinganine in an in vitro wound healing model. Nutrition Research and Practice, 4(5), 362-368. DOI: 10.4162/nrp.2010.4.5.36210.4162/nrp.2010.4.5.362298171821103081Open DOISearch in Google Scholar

Kimura, M., Kimura, Y., Tsumura, K., Okihara, K., Sugimoto, H., Yamada, H. (2003). 350-kDa royal jelly glycoprotein (apisin), which stimulates proliferation of human monocytes, bears the beta1–3galactosylated N-glycan: Analysis of the N-glycosylation site. Bioscience, Biotechnology, and Biochemistry, 67, 2055–2058. DOI: 10.1271/bbb.67.205510.1271/bbb.67.205514520005Open DOISearch in Google Scholar

Kodai, T., Umebayashi, K., Nakatani, T., Ishiyama, K., Noda, N. (2007). Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees (Apis mellifera). Chemical & Pharmaceutical Bulletin, 55(10), 1528-1531. PMID: 17917301.Search in Google Scholar

Koc, A. N., Silici, S., Kasap, F., Hörmet-O, H.T., Mavus-Buldu, H., Ercal, B. D. (2011). Antifungal activity of the honeybee products against Candida spp. and Trichosporon spp. Journal of Medicinal Food, 14(1-2), 128-34. DOI :org/10.1089/jmf.2009.029610.1089/jmf.2009.029621128826Open DOISearch in Google Scholar

Li, C., Mannoor, M. K., Toma, N., Taniguchi, T., Inafuku, M., Yamaguchi, K., Sato, Y., Watanabe, H. (2011). The efficacy of Royal Jelly in the restoration of alcoholic liver injury in mouse model. Biomedical Research, 22(1), 1-8.Search in Google Scholar

Majtan, J., Kumar, P., Majtan, T., Walls, A. F., Klaudiny, J. (2010). Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes. Experimental Dermatology, 19(8), 73-79. DOI: 10.1111/j.1600-0625.2009.00994.x10.1111/j.1600-0625.2009.00994.x19845754Search in Google Scholar

Majtan, J., Kovacova, E., Bilikova, K., & Simuth, J. (2006). The immunostimulatory effect of the recombinant apalbumin 1 - major honeybee royal jelly protein - on TNF alpha release. International immunopharmacology, 6(2), 269-278. DOI: 10.1016/j.intimp.2005.08.01410.1016/j.intimp.2005.08.01416399632Open DOISearch in Google Scholar

Mannoor, M. K., Tsukamoto, M., Watanabe, H., Yamaguchi, K., Sato, Y. (2008). The efficacy of royal jelly in the restoration of stress-induced disturbance of lymphocytes and granulocytes. Biomedical Research India, 19(2), 69-77.Search in Google Scholar

Mannoor, K. M., Shimabukuro, I., Tsukamotoa, M., Watanabe, H., Yamaguchi, K., Sato, Y. (2009). Honeybee royal jelly inhibits autoimmunity in SLE-prone NZB×NZW F1 mice. Lupus SAGE Publications Los Angeles, London, New Delhi and Singapore, 18, 44-52. DOI: 10.1177/096120330809476510.1177/096120330809476519074168Open DOISearch in Google Scholar

Mărghitaş, L.A. (2008). Produsele apicole şi principalele lor însuşiri terapeutice. In: Albinele şi produsele lor. L.A. Mărghitaş LA. Second edition. Bucharest: Ceres. pp. 280-378.Search in Google Scholar

Matsubara, T., Sugimoto, H., & Aida, M. (2008). A theoretical insight into the interaction of fatty acids involved in royal jelly with the human estrogen receptor beta. Bulletin of the Chemical Society of Japan, 81(10), 1258-1266. DOI: org/10.1246/bcsj.81.125810.1246/bcsj.81.1258Search in Google Scholar

Maqsoudlou, A., Sadeghi Mahoonak, A., Mora, L., Mohebodini, H., Toldrá, F., Ghorbani, M. (2018). Peptide identification in alcalase hydrolysated pollen and comparison of its bioactivity with royal jelly. Food Research International, 116, 905-915. DOI: 10.1016/j.foodres.2018.09.02710.1016/j.foodres.2018.09.027Open DOISearch in Google Scholar

Melliou, E., & Chinou, I. (2014). Chemistry and bioactivities of royal jelly. Studies in Natural Products Chemistry, 43, 261-290. DOI:org/10.1016/B978-0-444-63430-6.00008-410.1016/B978-0-444-63430-6.00008-4Open DOISearch in Google Scholar

Miki, K., Takeshi, T., & Yoshiyuki, K. (2001). Anti-obesity action of royal jelly (RJ) on mice fed a high-fat diet. Japan Science and Technology Agency, 63, 78-83.Search in Google Scholar

Mohebodini, H., Maqsoudlou, A., Dastar, B., & Tahmasebi, G. (2018). Royal jelly production, amount of royal jelly thiamine and hypopharyngeal glands development in Iranian honeybee (Apis mellifera meda) colonies fed with different levels of thiamine. Journal of Animal Researches, 31, 152-159.Search in Google Scholar

Moriyama, H., Bagchi, M., & Bagchi, D. (2017). Royal Jelly in Medicinal to Functional Energy Drinks. Sustained Energy for Enhanced Human Functions and Activity, Academic press, 281-298. DOI: org/10.1016/B978-0-12-805413-0.00018-110.1016/B978-0-12-805413-0.00018-1Open DOISearch in Google Scholar

Moutsatsou, P., Papoutsi, Z., Kassi, E., Heldring, N., Zhaohao, C., Tsiapara, A., ... Dahlman-Wright, K. (2010). Fatty acids derived from royal jelly are modulators of estrogen receptor functions. Plos One, 5, 15594. DOI : org/10.1371/journal.pone.001559410.1371/journal.pone.0015594Open DOISearch in Google Scholar

Moselhy, W. A., Fawzy, A. M., & Kamel, A. A. (2013). An evaluation of the potent antimicrobial effects and unsaponifiable matter analysis of the royal jelly. Life Science Journal, 10(2), 290-296.Search in Google Scholar

Munstedt, K., Bargello, M., & Hauenschild, A. (2009). Royal jelly reduces the serum glucose levels in healthy subjects. Journal of Medicinal Food, 12, 1170-1172. DOI: org/10.1089/jmf.2008.028910.1089/jmf.2008.0289Open DOISearch in Google Scholar

Münstedt, K., Böhme, M., Hrgovic, I., & Hauenschild, A. (2010). An approach to the application royal jelly: encapsulation of lyophilized royal jelly and its effect on glucose metabolism in humans. Journal of ApiProduct and ApiMedical Science, 2(1), 29-30. DOI: 10.3896/IBRA.4.02.1.0310.3896/IBRA.4.02.1.03Open DOISearch in Google Scholar

Nabas, Z., Haddadin, M. S. Y., Haddadin, J., & Nazer, I. K. (2014 a). Chemical composition of royal jelly and effects of synbiotic with two different locally isolated probiotic strains on antioxidant activities. Polish Journal of Food And Nutrition Sciences, 64(3), 171-180. DOI: org/10.2478/pjfns-2013-001510.2478/pjfns-2013-0015Open DOISearch in Google Scholar

Nabas, Z., Haddadin, M. S. Y., Haddadin, J., & Nazer, I. K. (2014 b). The influence of royal jelly addition on the growth and production of short chain fatty acids of two different bacterial species isolated from infants in Jordan. Pakistan Journal of Nutrition, 13, 43-49.10.3923/pjn.2014.43.49Search in Google Scholar

Nagai, T., Inoue, R., Suzuki, N., & Nagashima, T. (2008). Angiotensin I-converting enzyme inhibitory activities of enzymatic hydrolysates from royal jelly imported from China. Journal of Food, Agriculture & Environment, 6(3&4), 129-132.Search in Google Scholar

Nagai, T., Sakai, M., Inoue, R., & Suzuki, N. (2001). Antioxidative activities of some commercially honeys, royal jelly, and propolis. Food Chemistry, 75(2), 237-240. DOI: org/10.1016/S0308-8146(01)00193-510.1016/S0308-8146(01)00193-5Open DOISearch in Google Scholar

Nakajima. Y., Tsuruma. K., Shimazawa. M., Mishima S., Hara H. (2009). Comparison of bee products based on assays of antioxidant capacities. BMC Complementary and Alternative Medicine, 9(4), 1-9. DOI: org/10.1186/1472-6882-9-410.1186/1472-6882-9-4266478319243635Open DOISearch in Google Scholar

Nakaya, M., Onda, H., Sasaki, K., Yukiyoshi, A., Tachibana, H., Yamada, K. (2007). Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells. Bioscience, Biotechnology, and Biochemistry, 71(1), 253-255.10.1271/bbb.6045317213647Search in Google Scholar

Oribe, E., Arioka, T., Fukuda, K., Tatefuji, T., Hashimoto, K., Maeda, K. (2012). Moisturizing effect of royal jelly extract and its mechanism on skin. Journal of Dermatology, 39(1), 53-280.Search in Google Scholar

Park, H. M., Cho, M. H., CHO, Y., & Kim, S. Y. (2012). Royal jelly increases collagen production in rat skin after ovariectomy. Journal of Medicinal Food, 15(6), 568-575. DOI: org/10.1089/jmf.2011.188810.1089/jmf.2011.1888335963322468645Open DOISearch in Google Scholar

Park, H. M., Hwang, E., Lee, K. G., Han, S., M., Cho, Y., Kim, S. Y. (2010). Royal Jelly protects against ultraviolet b-induced photoaging in human skin fibroblasts via enhancing collagen production. Journal of Medicinal Food, 14(9), 1-8. DOI: org/10.1089/jmf.2010.136310.1089/jmf.2010.136321812645Open DOISearch in Google Scholar

Parveen, A., & Rao, S. (2012). Antibacterial activity and phytochemical analysis of leaf extracts of Aritolochia bracteolate. Asian Journal of Experimental Biological Sciences, 3(3), 577-581.Search in Google Scholar

Pasupuleti, V. R., Sammugam, L., Ramesh, N., & Gan, S. H. (2017). Honey, propolis, and royal jelly: a comprehensive review of their biological actions and health benefits. Hindawi Oxidative Medicine and Cellular Longevity, 21 pages. DOI: org/10.1155/2017/125951010.1155/2017/1259510554948328814983Open DOISearch in Google Scholar

Pavel, I., Marghitash, L. A., Dezmirena, D. S., Bobis, O., Barnuliu, L., Şapcaliu, A. (2011a). Changes in royal jelly composition during storage and possible freshness parameters. Bulletin UASVM Animal Science and Biotechnologies, 68(1-2), 245-248.Search in Google Scholar

Pavel, C. I., Mărghitaş, L. A., Bobiş, O., Dezmirean, D. S., Şapcaliu, A., Radoi, I., Mădaş, M. N. (2011b). Biological activities of royal jelly. Animal Science and Biotechnologies, 44(2), 108-118.Search in Google Scholar

Popescu, O., Marghitasl, A., & Dezmireand, L. (2008). A study about physicochemical composition of fresh and lyophilized royal jelly. Zootehnie şi Biotehnologii, 41(2), 328-332.Search in Google Scholar

Pourmoradian, S., Mahdavi, R., Mobasseri, M., Faramarzi, E., Mobasseri, M. (2012). Effects of royal jelly supplementation on body weight and dietary intake in type 2 diabetic females. Health Promotion Perspectives, 2(2), 231-235. DOI: 10.5681/hpp.2012.02810.5681/hpp.2012.028396364624688939Open DOISearch in Google Scholar

Pyrzanowska, J., Piechal, A., Blecharz-klin, K., Graikou, K., Widy-Tyszkiewicz, E., Chiinou, I. (2012). Chemical analysis of Greek royal jelly - Its influence of the long-term administration on spatial memory in aged rats. Planta Medica Journal, 78(11), 1248-1253. DOI: 10.1055/s-0032-132115410.1055/s-0032-1321154Open DOISearch in Google Scholar

Ramadan, M. F., & Al-Ghamdi, A. (2012). Bioactive compounds and health-promoting properties of royal jelly. Journal of Functional Foods, 4, 39-52. DOI: org/10.1016/j.jff.2011.12.00710.1016/j.jff.2011.12.007Open DOISearch in Google Scholar

Romanelli, A., Moggio, L., Montella, R. C., Campiglia, P., Iannaccone, M., Capuano, F., Pedone, C., Capparelli, R. (2011). Peptides from royal jelly: studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins. Journal of Peptide Science, 17(5), 348-352. DOI: 10.1002/psc.131610.1002/psc.131621254310Open DOISearch in Google Scholar

Sabatini, A. G., Marcazzan, G. L., Caboni, M. F., Bogdanov, S., Almeida-Muradian, L. B. DE. (2009). Quality and stadarisation of royal jelly. Journal of ApiProducts and ApiMedical Sciences, 1(1), 16-21. DOI: 10.3896/IBRA.4.01.1.0410.3896/IBRA.4.01.1.04Open DOISearch in Google Scholar

Sabatini, A. G., Marcazzan, G., Caboni, M. F., Bogdanov, S., Almedia-Muradian, L. B. (2009). Quality and standardisation of royal jelly. Journal of Analytical Atomic Spectrometry, 1, 1-6. DOI: 10.3896/IBRA.4.1.01.0410.3896/IBRA.4.1.01.04Open DOISearch in Google Scholar

Salazar-Olivo, L. & Paz-González, V. (2005). Screening of biological activities present in honeybee (Apis mellifera) royal jelly. Toxicology in Vitro, 19, 645–651.10.1016/j.tiv.2005.03.00115893447Search in Google Scholar

Salem, F. (2013). Modulatory effects of Trifolium pratense extract and royal jelly on the function of hypothalamic-pituitary-ovarianaxis in ovariectomized rates. International Journal of Pharmacy and Pharmaceutical, 5(3), 593-597.Search in Google Scholar

Schonleben, S., Sickmann, A., Mueller, M. J., & Reinders, J. (2007). Proteome analysis of Apis mellifera royal jelly. Analytical and Bioanalytical Chemistry, 389, 1087-1093. DOI: 10.1007/s00216-007-1498-210.1007/s00216-007-1498-217673985Search in Google Scholar

Seyyedi, F., Rafiean-Kopaei, M., & Miraj, S. (2016). Comparison of the effects of vaginal royal jelly and vaginal estrogen on quality of life, sexual and urinary function in postmenopausal women. Journal of Clinical and Diagnostic Research, 10(5), 10-16. DOI: 10.7860/JCDR/2016/17844.771510.7860/JCDR/2016/17844.7715494848227437306Open DOISearch in Google Scholar

Sesta, G. & Lusco, L. (2009). Refractometric determination of water content in royal Jelly. Apidologie, 39, 225-232.10.1051/apido:2007053Search in Google Scholar

Shahzad, Q., Mehmoodb, M. U., Khan, H., Husna, A., Qadeerd, S., Azam, A., Naseere, A., Ahmad, E., Safdar, M., Ahmad, M. (2016). Royal jelly supplementation in semen extender enhances post-thaw quality and fertility of Nili-Ravi buffalo bull sperm. Animal Reproduction Science, 167, 83-88. DOI: 10.1016/j.anireprosci.2016.02.01010.1016/j.anireprosci.2016.02.01026896924Open DOISearch in Google Scholar

Shen, L.R., Ding, M.H., Zhang, L.W., Jin, F., Zhang, W.G., Li, D. (2010). Expression of Acc-Royalisin gene from royal jelly of Chinese honeybee in Escherichia coli and its antibacterial activity. Journal of Agricultural and Food Chemistry, 58(4), 2266-2273.10.1021/jf902574t20121109Search in Google Scholar

Shirzad, M., Kordyazdi, R., Shahinfard, N., & Nikokar M. (2013). Does Royal jelly affect tumor cells? Journal of Herb Med Pharmacology, 2(2), 45-48. DOI: 10.1021/jf902574t10.1021/jf902574tOpen DOISearch in Google Scholar

Siavash, M., Shokri, S., Haghighi, S., Mohammadi, S., Shahtalebi, M. A., Farajzadehgan, Z. (2011). The efficacy of topical RoyalJelly on diabetic foot ulcers healing: A case series. International Journal of Research in Medical Sciences, 16(7), 904-909. PMID: 22279458.Search in Google Scholar

Siavash, M., Shokri, S., Haghighi, S., Mohammadi, S., Shahtalebi, M. A., Farajzadehgan, Z. (2015). The efficacy of topical royal jelly on healing of diabetic foot ulcers: a double-blind placebo-controlled clinical trial. International Wound Journal, 12(2), 137–142. DOI: 10.1111/iwj.1206310.1111/iwj.12063795067423566071Open DOISearch in Google Scholar

Silici, S., Ekmekcioglu, O., Kanbur, M., & Deniz, K. (2010). The protective effect of royal jelly against cisplatin-induced renal oxidative stress in rats. World Journal of Urology, 29(1), 127–132. DOI: 10.1007/s00345-010-0543-510.1007/s00345-010-0543-520369241Open DOISearch in Google Scholar

Simsek, N., Karadeniz, A., & Bayraktaroglu, A. G. (2009). Effects of L-carnitine, royal jelly and pomegranate seed on peripheral blood cells in rats. Kafkas Universitesi Veteriner Fakultesi Dergisi, 15(1), 63-69.Search in Google Scholar

Šimúth, J. (2001). Some properties of the main protein honeybee (Apis mellifera L.) royal jelly. Apidologie, 32, 69-80.10.1051/apido:2001112Search in Google Scholar

Sugiyama, T., Takahashi, K., Kuzumaki, A., Tokoro, S., Neri, P., Mori, H. (2013). Inhibitory mechanism of 10 hydroxy trans 2 decenoic acid (royal jelly acid) against lipopolysaccharide and interferon beta induced nitric oxide production. Inflammation, 36(2), 372-378. DOI: 10.1007/s10753-012-9556-010.1007/s10753-012-9556-023079939Search in Google Scholar

Suzuki, K. M., Isohama, Y., Maruyama, H., Yamada, Y., Narita, Y., Ohta, S., … Mishima, S. (2008). Estrogenic activities of fatty acids and a sterol isolated from royal jelly. Evidence-Based Complementary and Alternative Medicine, 5(3), 295-302. DOI: 10.1093/ecam/nem03610.1093/ecam/nem036252937818830443Open DOISearch in Google Scholar

Takaki-Doi, S., Hashimoto, K., Yamamura, M., & Kamei, C. (2009). Antihypertensive activities of royal jelly protein hydrolysate and its fractions in spontaneously hypertensive rats. Acta medica Okayama, 63(1), 57-64. DOI: 10.18926/AMO/31859Search in Google Scholar

Tamura, S., Kono, T., Harada, C., Yamaguchi, K., & Moriyama, T. (2009). Estimation and characterisation of major royal jelly proteins obtained from the honeybee Apis merifera. Food Chemistry, 114, 1491-1497. DOI: org/10.1016/j.foodchem.2008.11.05810.1016/j.foodchem.2008.11.058Open DOISearch in Google Scholar

Teixeira, R. R., Souza, A. V., Peixoto, L. G., Machado, H. L., Caixeta, D. C., Vilela, D. D., ... Espindola, F. S. (2017). Royal jelly decreases corticosterone levels and improves the brain antioxidant system in restraint and cold stressed rats. Neuroscience Letters. 17 pages. DOI: 10.1016/j.neulet.2017.07.01010.1016/j.neulet.2017.07.01028709905Open DOISearch in Google Scholar

Tatsuhiko, T., Naoko, K., & Yuko, H. (2011). Application of the material of honeybee origin. Application of the consmetic material of the honeybee origin (Japanese). Frag Journal, 30, 17-24.Search in Google Scholar

Terada, Y., Narukawa, M., & Watanabe, T. (2011). Specific hydroxy fatty acids in royal jelly activate TRPA1. Journal of Agricultural and Food Chemistry, 59, 2627-2635. DOI: 10.1021/jf104164610.1021/jf104164621348496Open DOISearch in Google Scholar

Trombetta, D., Castelli, F., Sarpietro, M. G., Venuti, V., Cristani, M., Daniele, C., … Bisignano, G. (2005). Mechanisms of antibacterial action of three monoterpenes. Antimicrobial Agents and Chemotherapy, 2474-2478.10.1128/AAC.49.6.2474-2478.2005114051615917549Search in Google Scholar

Viuda-Martos, M., Ruiz-Navajas Y., Fernández-López, J., & Pérez-Alvarez, J. A. (2008). Functional properties of honey, propolis, and royal jelly. Journal of Food Science, 73(9), 117-24. DOI: 10.1111/j.1750-3841.2008.00966.x10.1111/j.1750-3841.2008.00966.x19021816Open DOISearch in Google Scholar

Wei, W., Wei, M., Kang, X. J., Deng, H. H., Lu, Z. H. (2009). A novel method developed for acetyl choline detection in royal jelly by using capillary electrophoresis coupled with electrogenerated chemiluminescence based on a simple reaction. Electrophoresis, 30(11), 1949-1952. DOI: 10.1002/elps.20080072110.1002/elps.20080072119517434Open DOISearch in Google Scholar

Wongcha, V., & Ratanavalacha, T. (2002). Seasonal variation of chemical composition of royal jelly produced in Thailand. Thammasat International Journal of Science and Technology, 7(2), 1-8.Search in Google Scholar

Wu, L., Chen, L., Selvaraj, N. J., Wei, Y., Wang, Y., Li, Y., Zhao, J., Xue, X. (2015). Identification of the distribution of adenosine phosphates, nucleosides and nucleobases in royal jelly. Food Chemistry, 173, 1111-1118. DOI: 10.1016/j.foodchem.2014.10.13710.1016/j.foodchem.2014.10.13725466132Open DOISearch in Google Scholar

Xue, X. F., Zhou, J. H., Wu, L. M., Fu, L. H., Zhao, J. (2009). HPLC determination of adenosine in royal jelly. Food Chemistry, 115, 715-719. DOI:org/10.1016/j.foodchem.2008.12.00310.1016/j.foodchem.2008.12.003Open DOISearch in Google Scholar

Yamaura, K., Tomono, A., Suwa, E., & Ueno, K. (2013). Topical royal jelly alleviates symptoms of pruritus in a murine model of allergic contact dermatitis. Pharmacognosy Magazine, 9(33), 9-13. DOI: 10.4103/0973-1296.10812710.4103/0973-1296.108127364740123661987Open DOISearch in Google Scholar

Yang, X. Y., Yang, D. S., Wei, Z., Wang, J. M., Li, C.Y., Ye, H., … Wang, J. G. (2010). 10-Hydroxy-2-decenoic acid from royal jelly: a potential medicine for RA. Journal of Ethnopharmacology, 128(2), 314-321. DOI: 10.1016/j.jep.2010.01.05510.1016/j.jep.2010.01.05520138211Search in Google Scholar

Zamami, Y., Takatori, S., Goda, M., Koyama, T., Iwatani, Y., Jin, X. (2008). Royal jelly ameliorates insulin resistance in fructose-drinking rats. Biological and Pharmaceutical Bulletin, 31(11), 2103-2107. PMID: 1898158110.1248/bpb.31.210318981581Search in Google Scholar

Zheng, H. Q., Wei, W. T., Wu, L. M., Hu, F. L., Dietemann, V. (2012). Fast determination of royal jelly freshness by a chromogenic reaction. Journal of Food Science, 77(6), 247-252. DOI: 10.1111/j.1750-3841.2012.02726.x10.1111/j.1750-3841.2012.02726.x22671531Open DOISearch in Google Scholar