[Alwahsh SM, Xu M, Seyhan HA, Ahmad S, Mihm S, Ramadori G, Schultze FC. Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver. World J Gastroenterol 20, 1807–1821, 2014.10.3748/wjg.v20.i7.1807393097924587658]Open DOISearch in Google Scholar
[Bouillon R, Bex M, Van Herck E, Laureys J, Dooms L, Lesaffre E, Ravussin E. Influence of age, sex, and insulin on osteoblast function: osteoblast dysfunction in diabetes mellitus. J Clin Endocrinol Metab 80, 1194–1202, 1995.771408910.1210/jcem.80.4.77140897714089]Search in Google Scholar
[de Liefde II, van der Klift M, de Laet CE, van Daele PL, Hofman A, Pols HA. Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study. Osteoporos Int 16, 1713–1720, 2005.10.1007/s00198-005-1909-115940395]Search in Google Scholar
[Ducy P. The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism. Diabetologia 54, 1291–1297, 2011.10.1007/s00125-011-2155-z2150374021503740]Open DOISearch in Google Scholar
[Ferron M, McKee MD, Levine RL, Ducy P, Karsenty G. Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice. Bone 50, 568–575, 2012.10.1016/j.bone.2011.04.01721550430318126721550430]Open DOISearch in Google Scholar
[Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432, 917–921, 2004.10.1038/nature0310415531878]Search in Google Scholar
[Francisco V, Pino J, Gonzalez-Gay MA, Mera A, Lago F, Gomez R, Mobasheri A, Gualillo O. Adipokines and inflammation: is it a question of weight? Br J Pharmacol 175, 1569–1579, 2018.10.1111/bph.14181591339729486050]Search in Google Scholar
[Giudici KV, Fisberg RM, Marchioni DML, Peters BSE, Martini LA. Crosstalk between bone and fat tissue: associations between vitamin D, osteocalcin, adipokines, and markers of glucose metabolism among adolescents. J Am Coll Nutr 36, 273–280, 2017.10.1080/07315724.2016.127492328443718]Open DOISearch in Google Scholar
[Gomez-Chou SB, Swidnicka-Siergiejko AK, Badi N, Chavez-Tomar M, Lesinski GB, Bekaii-Saab T, Farren MR, Mace TA, Schmidt C, Liu Y, Deng D, Hwang RF, Zhou L, Moore T, Chatterjee D, Wang H, Leng X, Arlinghaus RB, Logsdon CD, Cruz-Monserrate Z. Lipocalin-2 promotes pancreatic ductal adenocarcinoma by regulating inflammation in the tumor microenvironment. Cancer Res 77, 2647–2660, 2017.10.1158/0008-5472.CAN-16-1986544123028249896]Search in Google Scholar
[Guntur AR, Rosen CJ. Bone as an endocrine organ. Endocr Pract 18, 758–762, 2012.10.4158/EP12141.RA357165422784851]Open DOISearch in Google Scholar
[Guo H, Jin D, Zhang Y, Wright W, Bazuine M, Brockman D, Bernlohr D, Chen, X. Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice. Diabetes 59, 1376–1385, 2010.10.2337/db09-1735287469820332347]Search in Google Scholar
[Herman W. The global burden of diabetes: An overview. In: Diabetes mellitus in developing countries and under-served communities (Ed. S. Dagogo-Jack), Springer International Publishing, Switzerland, pp. 1–5, 2017.10.1007/978-3-319-41559-8_1]Search in Google Scholar
[Holt SK, Karyadi DM, Kwon EM, Stanford JL, Nelson PS, Ostrander EA. Association of Megalin genetic polymorphisms with prostate cancer risk and prognosis. Clin Cancer Res 14, 3823–3831, 2008.10.1158/1078-0432.CCR-07-4566267588318559602]Open DOISearch in Google Scholar
[Hvidberg V, Jacobsen C, Strong RK, Cowland JB, Moestrup SK, Borregaard N. The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett 579, 773–777, 2005.10.1016/j.febslet.2004.12.03115670845]Search in Google Scholar
[Ivers RQ, Cumming RG, Mitchell P, Peduto AJ; Blue Mountains Eye Study. Diabetes and risk of fracture. Diabetes Care 24, 1198–1203, 2001.10.2337/diacare.24.7.119811423502]Open DOISearch in Google Scholar
[Janghorbani M, Van Dam RM, Willett WC, Hu FB. Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol 166, 495–505, 2007.10.1093/aje/kwm10617575306]Search in Google Scholar
[Kanazawa I, Yamaguchi T, Yamauchi M, Yamamoto M, Kurioka S, Yano S, Sugimoto T. Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int 22, 187–194, 2011.10.1007/s00198-010-1184-720165834]Search in Google Scholar
[Kanazawa I. Osteocalcin as a hormone regulating glucose metabolism. World J Diabetes 6, 1345–1354, 2015.10.4239/wjd.v6.i18.1345468977926722618]Search in Google Scholar
[Karsenty G, Oury F, Biology without walls: the novel endocrinology of bone. Annu Rev Physiol 74, 87–105, 2012.10.1146/annurev-physiol-020911-15323322077214]Search in Google Scholar
[Lambertz J, Berger T, Mak TW, van Helden J, Weiskirchen R. Lipocalin-2 in fructose-induced fatty liver disease. Front Physiol 8, 964, 2017.2923428810.3389/fphys.2017.00964571234629234288]Search in Google Scholar
[Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell 130, 456–469, 2007.10.1016/j.cell.2007.05.047201374617693256]Search in Google Scholar
[Liang Y, Tan A, Liang D, Yang X, Liao M, Gao Y, Jiang Y, Yao Z, Lin X, Lu Z, Wu C, Zhang S, Hu Y, Qin X, Mo Z, Li H, Zhang H. Low osteocalcin level is a risk factor for impaired glucose metabolism in a Chinese male population. J Diabetes Investig 7, 522–528, 2016.10.1111/jdi.12439493120227181428]Search in Google Scholar
[Marzolo PM, Farfan P. New insights into the roles of megalin/LRP2 and the regulation of its functional expression. Biol Res 44, 89–105, 2011.10.4067/S0716-9760201100010001221720686]Search in Google Scholar
[Mera P, Ferron M, Mosialou I. Regulation of energy metabolism by bone-derived hormones. Cold Spring Harb Perspect Med 8, a031666, 2018.10.1101/cshperspect.a031666598315928778968]Search in Google Scholar
[Mizokami A, Wang D, Tanaka M, Gao J, Takeuchi H, Matsui T, Hirata M. An extract from pork bones containing osteocalcin improves glucose metabolism in mice by oral administration. Biosci Biotechnol Biochem 80, 2176–2183, 2016.10.1080/09168451.2016.121453027460506]Open DOISearch in Google Scholar
[Miyamoto T, Asaka R, Suzuki A, Takatsu A, Kashima H, Shiozawa T. Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma. Exp Mol Pathol 91, 563–568, 2011.10.1016/j.yexmp.2011.06.00221763306]Search in Google Scholar
[Mosialou I, Shikhel S, Liu J, Maurizi A, Luo N, He Z, Huang Y, Zong H, Friedman R, Barasch J, Lanzano P, Deng L, Leibel R, Rubin M, Nickolas T, Chung W, Zeltser L, Williams K, Pessin J, Kousteni S. MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature 543, 385–390, 2017.10.1038/nature21697597564228273060]Search in Google Scholar
[Neumann T, Lodes S, Kastner B, Franke S, Kiehntopf M, Lehmann T, Muller UA, Wolf G, Samann A. Osteocalcin, adipokines and their associations with glucose metabolism in type 1 diabetes. Bone 82, 50–55, 2016.10.1016/j.bone.2015.04.01725888930]Open DOISearch in Google Scholar
[Neve A, Corrado A, Cantatore FP. Osteocalcin: skeletal and extra-skeletal effects. J Cell Physiol 228, 1149–1153, 2013.10.1002/jcp.2427823139068]Search in Google Scholar
[Palmiter RD. Physiology: Bone-derived hormone suppresses appetite. Nature 543, 320–322, 2017.10.1038/nature2150128273066]Search in Google Scholar
[Pi M, Wu Y, Quarles LD. GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo. J Bone Miner Res 26, 1680–1683, 2011.10.1002/jbmr.39021425331507953621425331]Open DOISearch in Google Scholar
[Pi M, Kapoor K, Ye R, Nishimoto SK, Smith JC, Baudry J, Quarles LD. Evidence for osteocalcin binding and activation of GPRC6A in β-cells. Endocrinology 157, 1866–1880, 2016.10.1210/en.2015-2010487087527007074]Search in Google Scholar
[Rached MT, Kode A, Silva BC, Jung DY, Gray S, Ong H, Paik JH, DePinho RA, Kim JK, Karsenty G, Kousteni S. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest 120, 357–368, 2010.10.1172/JCI39901279868720038793]Search in Google Scholar
[Saleem U, Mosley TH Jr, Kullo IJ. Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. Arterioscler Thromb Vasc Biol 30, 1474–1478, 2010.10.1161/ATVBAHA.110.204859293991020395593]Open DOISearch in Google Scholar
[Vestergaard P. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes-a meta-analysis. Osteoporos Int 18, 427–444, 2007.10.1007/s00198-006-0253-417068657]Search in Google Scholar
[Visscher V, Rassekh SR, Sandor GS, Caron HN, van Dalen EC, Kremer LC, van der Pal HJ, Rogers PC, Rieder MJ, Carleton BC, Hayden MR, Ross CJ; CPNDS consortium. Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children. Pharmacogenomics 16, 1065–1076, 2015.10.2217/pgs.15.6126230641]Search in Google Scholar
[Wang Y, Zhou Y, Graves DT. FOXO transcription factors: their clinical significance and regulation. Biomed Res Int 2014, 925350, 2014.10.1155/2014/925350401684424864265]Search in Google Scholar
[Wei J, Karsenty G. An overview of the metabolic functions of osteocalcin. Rev Endocr Metab Disord 16, 93–98, 2015.10.1007/s11154-014-9307-7449932725577163]Search in Google Scholar
[Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes 56, 2533–2540, 2007.1763902110.2337/db07-000717639021]Search in Google Scholar