<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The bones form the framework of our body. We know that bones protect our vital organs, regulate calcium and phosphorous homeostasis, and function as a site of erythropoiesis. More recently, however, the identification of bone hormones has allowed us to envision bones as endocrine organs too. Within the last few years, the bone hormones osteocalcin and lipocalin 2 have been implicated with glucose and energy metabolism. We systematically reviewed articles surrounding this subject and found a clear relationship between the osteocalcin levels and glucose tolerance and insulin sensitivity. We also found that many journals have shown the detrimental effects of an absences of lipocalin 2 from adipocytes. As osteocalcin administration to mice showed decreased blood glucose levels and promoted glucose tolerance and insulin sensitivity. Future studies could perhaps explore the use of osteocalcin as a supplement for type 2 diabetes.</p></abstract>

The bones form the framework of our body. We know that bones protect our vital organs, regulate calcium and phosphorous homeostasis, and function as a site of erythropoiesis. More recently, however, the identification of bone hormones has allowed us to envision bones as endocrine organs too. Within the last few years, the bone hormones osteocalcin and lipocalin 2 have been implicated with glucose and energy metabolism. We systematically reviewed articles surrounding this subject and found a clear relationship between the osteocalcin levels and glucose tolerance and insulin sensitivity. We also found that many journals have shown the detrimental effects of an absences of lipocalin 2 from adipocytes. As osteocalcin administration to mice showed decreased blood glucose levels and promoted glucose tolerance and insulin sensitivity. Future studies could perhaps explore the use of osteocalcin as a supplement for type 2 diabetes.

The bone hormones and their potential effects on glucose and energy metabolism

Department of Physiology, Faculty of Medicine

Endocrine Regulations

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The bone hormones and their potential effects on glucose and energy metabolism"}

The bones form the framework of our body. We know that bones protect our vital organs, regulate calcium and phosphorous homeostasis, and function as a site of...

The bone hormones and their potential effects on glucose and energy metabolism

Published Online: Nov 15, 2019

Page range: 268 - 273

DOI: https://doi.org/10.2478/enr-2019-0027

Keywords
osteocalcin, lipocalin 2, glucose, insulin, energy metabolism

© 2019 Daniel Addai et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The bone hormones and their potential effects on glucose and energy metabolism

Published Online: Nov 15, 2019

Page range: 268 - 273

DOI: https://doi.org/10.2478/enr-2019-0027

Keywordsosteocalcin, lipocalin 2, glucose, insulin, energy metabolism

© 2019 Daniel Addai et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
osteocalcin, lipocalin 2, glucose, insulin, energy metabolism