New strategies for the control of infectious and parasitic diseases in blood donors: the impact of pathogen inactivation methods
and | Apr 30, 2020
About this article
Article Category: Review
Published Online: Apr 30, 2020
Page range: 53 - 66
DOI: https://doi.org/10.2478/ebtj-2020-0007
Keywords
© 2020 Luca Galli and Fabrizio Bruschi, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
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Reduction of infectious disease agent logs induced by different PI technologiesResults are expressed as > number indicate that the pathogen concentrations was reduced to the limit of detection of the assay
| Pathogen | Amotosalen/UVA | Riboflavin/UV | UVC | Amustaline-GSH | |
|---|---|---|---|---|---|
| HBV | Enveloped virus | >5.5 ( | 2.5 ( | na not available. | >5.1 ( |
| HCV | Enveloped virus | >4.5 ( | 3.2 ( | >4.9 ( | na not available. |
| HIV (cell free) latent | Enveloped virus | >6.2 ( | >4.5 ( | 1.4 ( | >6.5 ( |
| HIV (cell-associated) active | Enveloped virus | >6.1 ( | >5.9 ( | na not available. | >5.9 ( |
| CMV | Enveloped virus | >5.9 ( | 2.1 ( | na not available. | >6 ( |
| WNV | Enveloped virus | >6.0 ( | >5.1 ( | 3.4 - 4 ( | > 6.0 ( |
| CHIKV | Enveloped virus | >6.9 ( | 2.1 - 4 ( | 6.34 ( | > 6.78 ( |
| Influenza A virus | Enveloped virus | >5.9 ( | >5 ( | na not available. | na not available. |
| HAV | Nonenveloped virus | 0.6 ( | 1.8 ( | 4.2 ( | na not available. |
| Parvovirus B19 | Nonenveloped virus | 3.5-5.0 ( | >5 ( | 5.4 ( | na not available. |
| Zika Virus | Enveloped virus | > 6 ( | na not available. | 5.7 ( | 5.99 ( |
| Dengue Virus | Enveloped virus | > 4.3 ( | 1.8 ( | >4.6 ( | 6.61 ( |
| Bacteria (Gram positive) | >6.6 ( | 4.8 ( | >4.4 ( | 5.1 ( | |
| Bacteria (Gram positive) | >6.6 ( | 4.2 ( | 4.6 ( | > 6.9 ( | |
| Bacteria (Gram negative) | 4.5 ( | 4.5 ( | 4.9 ( | 4.5 ( | |
| Bacteria negative) (Gram | >6.4 ( | 4.4 ( | 7.3 ( | >6.7 ( | |
| Bacteria (Gram negative) | > 6.7 ( | 4 ( | > 5 ( | 5.1 ( | |
| Bacteria (Gram negative) | > 5.9 ( | 3.3 ( | na not available. | >6.8 ( | |
| Protozoa | >5.3 ( | >5 ( | na not available. | > 5.4 ( | |
| Protozoa | >6 ( | >3.2 ( | na not available. | > 6.8 ( | |
| Protozoa | > 5.3 ( | >4 ( | > 5 ( | >5.5 ( | |