<abstract xmlns="http://www.w3.org/1999/xhtml">Around 70 infectious agents are possible threats for blood safety.The risk for blood recipients is increasing because of new emergent agents like West Nile, Zika and Chikungunya viruses, or parasites such as <italic>Plasmodium</italic> and <italic>Trypanosoma cruzi</italic> in non-endemic regions, for instance.Screening programmes of the donors are more and more implemented in several Countries, but these cannot prevent completely infections, especially when they are caused by new agents.Pathogen inactivation (PI) methods might overcome the limits of the screening and different technologies have been set up in the last years.This review aims to describe the most widely used methods focusing on their efficacy as well as on the preservation integrity of blood components.</abstract>

Around 70 infectious agents are possible threats for blood safety.The risk for blood recipients is increasing because of new emergent agents like West Nile, Zika and Chikungunya viruses, or parasites such as Plasmodium and Trypanosoma cruzi in non-endemic regions, for instance.Screening programmes of the donors are more and more implemented in several Countries, but these cannot prevent completely infections, especially when they are caused by new agents.Pathogen inactivation (PI) methods might overcome the limits of the screening and different technologies have been set up in the last years.This review aims to describe the most widely used methods focusing on their efficacy as well as on the preservation integrity of blood components.

New strategies for the control of infectious and parasitic diseases in blood donors: the impact of pathogen inactivation methods

The EuroBiotech Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Around 70 infectious agents are possible threats for blood safety.The risk for blood recipients is increasing because of new emergent agents like West Nile,...

New strategies for the control of infectious and parasitic diseases in blood donors: the impact of pathogen inactivation methods

Article Category: Review

Published Online: Apr 30, 2020

Page range: 53 - 66

DOI: https://doi.org/10.2478/ebtj-2020-0007

Keywords
blood donors, viruses, bacteria, protozoa, Pathogen inactivation methods, plasma, platelets, red cells

© 2020 Luca Galli and Fabrizio Bruschi, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

New strategies for the control of infectious and parasitic diseases in blood donors: the impact of pathogen inactivation methods

Article Category: Review

Published Online: Apr 30, 2020

Page range: 53 - 66

DOI: https://doi.org/10.2478/ebtj-2020-0007

Keywordsblood donors, viruses, bacteria, protozoa, Pathogen inactivation methods, plasma, platelets, red cells

© 2020 Luca Galli and Fabrizio Bruschi, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
blood donors, viruses, bacteria, protozoa, Pathogen inactivation methods, plasma, platelets, red cells