<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The aim of this study was in vitro evaluation of the level of the immune response in relation to wound dressings composed of alginate, calcium carboxymethylcellulose, and dibutyrylochitin and determination of the direction of response, which will make referring next to the results of in vivo phase possible. </p><p>The subject of the experiments was to examine the commercially available, biodegradable alginate dressing, commercially available but not biodegradable dressing constructed from the sodium carboxymethylcellulose, and synthesized in house biodegradable dressing constructed of the dibutyrylchitin. To determine the direction of the immune response, the degree of secretion of pro-inflammatory interleukin (IL-1, IL-6) and antiinflammatory (IL-10) interleukin from murine fibroblasts having contact with the tested dressings (ELISA enzyme linked immunosorbent assay), was tested.</p></abstract>

The aim of this study was in vitro evaluation of the level of the immune response in relation to wound dressings composed of alginate, calcium carboxymethylcellulose, and dibutyrylochitin and determination of the direction of response, which will make referring next to the results of in vivo phase possible. The subject of the experiments was to examine the commercially available, biodegradable alginate dressing, commercially available but not biodegradable dressing constructed from the sodium carboxymethylcellulose, and synthesized in house biodegradable dressing constructed of the dibutyrylchitin. To determine the direction of the immune response, the degree of secretion of pro-inflammatory interleukin (IL-1, IL-6) and antiinflammatory (IL-10) interleukin from murine fibroblasts having contact with the tested dressings (ELISA enzyme linked immunosorbent assay), was tested.

In vitro evaluation of immunogenic properties of active dressings

Ph.D. Student, Medical University of Lodz, Pl. Hallera 1, 90-647 Lodz, Poland

Science and Research Laboratory Dermin Sp. z o.o., Milionowa 23, 93-193 Lodz, Po

Department of Biopharmaceutics, Medical University of Lodz, Muszynskiego 1, 90-153 Lodz, Poland

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"In vitro evaluation of immunogenic properties of active dressings"}

The aim of this study was in vitro evaluation of the level of the immune response in relation to wound dressings composed of alginate, calcium...

In vitro evaluation of immunogenic properties of active dressings

Published Online: May 30, 2014

Page range: 55 - 60

Received: Feb 20, 2014

Accepted: Mar 10, 2014

DOI: https://doi.org/10.2478/cipms-2014-0014

Keywords
dressings, immune response, inflammation

© 2014

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

In vitro evaluation of immunogenic properties of active dressings

Published Online: May 30, 2014

Page range: 55 - 60

Received: Feb 20, 2014

Accepted: Mar 10, 2014

DOI: https://doi.org/10.2478/cipms-2014-0014

Keywordsdressings, immune response, inflammation

© 2014

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
dressings, immune response, inflammation