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Aqueous Extract of Carica Papaya Linn Roots Halts Sodium Arsenite-Induced Renal Inflammation through Inhibiting Adenosine Deaminase, 8-Hydroxy-2′-Deoxyguanosine, C-Reactive Protein and Inducible Nitric Oxide Synthase Activity


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1. IARC (International Agency for Research on Cancer). Monographs on evaluation of carcinogenic risk to humans. In: Some Drinking Water Disinfectants and Contaminants, including Arsenic. 2004; 84: 269–477.Search in Google Scholar

2. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Arsenic TP-92/09, Center for Disease Control, Atlanta, Georgia, 2000.Search in Google Scholar

3. Vahter M, Concha G (2001) Role of metabolism in arsenic toxicity. Pharmacol Toxicol. 2001; 89 (1): 1–5.10.1034/j.1600-0773.2001.d01-128.x11484904Search in Google Scholar

4. Rossman TG, Uddin AN, Burns FJ. Evidence that arsenic acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol. 2004; 198 (3):394–404.10.1016/j.taap.2003.10.01615276419Search in Google Scholar

5. Tchounwou PB, Centeno JA, Patlolla AK. Arsenic toxicity, mutagenesis, and carcinogenesis — a health risks assessment and management approach. Mol Cell Biochem. 2004; 255(1-2): 47–55.10.1023/B:MCBI.0000007260.32981.b9Search in Google Scholar

6. Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007; 39, 44-84.Search in Google Scholar

7. Kotyzová D, Bludovská M, Eybl E. Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats. Environ Toxicol Pharmacol. 2013; 36 (3): 1015-1021.10.1016/j.etap.2013.09.00324095718Open DOISearch in Google Scholar

8. Sohini S, Rana SVS. Amelioration of arsenic toxicity by L-ascorbic acid in laboratory rat. J Environ Biol. 2007; 28 (2):377-384.Search in Google Scholar

9. Patel HV, Kalia K. Sub chronic arsenic exposure aggravates nephrotoxicity in experimental diabetic rats. Ind J Exper Biol. 2010; 48: 762-768.Search in Google Scholar

10. Flora SJS, Mittal M, Mehta A. Heavy metal induced oxidative stress &its possible reversal by chelation therapy. Ind J Med Res. 2008; 128: 501-523.Search in Google Scholar

11. Saxena PN, Anand S, Saxena N, et al. Effect of arsenic trioxide on renal functions and its modulation by Curcuma aromatica leaf extract in albino rat. J Environ Biol. 2009; 30 (4):527-531.Search in Google Scholar

12. Ojo OA, Oyinloye BE, Ajiboye BO, et al. Dichlorvos Induced Nephrotoxicity in Rat Kidney: Protective Effects of Alstonia boonei Stem Bark. Int J Pharmacog. 2014a; 1(7): 429-437.Search in Google Scholar

13. Subash PP, Gurumurthy A, Sarasabharathi KM, et al. Urinary 8-oHdG: A marker of oxidative stress to DNA and Total Antioxidant status in essential hypertension with south Indian population. Ind J Clin Biochem. 2010; 25(2): 127.10.1007/s12291-010-0024-z345310523105898Search in Google Scholar

14. Hart ML, Much C, Gorzolla IC, et al. Extracellular adenosine production by ecto-5′-nucleotidase protects during murine hepatic ischemic preconditioning. Gastroenterol. 2008; 135:1739-50.10.1053/j.gastro.2008.07.06418804111Search in Google Scholar

15. Bauerle JD, Grenz A, Kim JH, et al. Adenosine generation and signaling during acute kidney injury. J Am Soc Nephrol. 2011; 22:14-20.10.1681/ASN.200912121721209250Search in Google Scholar

16. Ramani K, Tomasi ML, Yang H et al. (2012) Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. J Biol Chem. 2012; 287:36341-55.10.1074/jbc.M112.370775347630122942279Search in Google Scholar

17. Dick G. “Papaya”: A tantalising taste of the Tropics. Maricopa County Master Gardener Volunteer information, University of Arizona Cooperative Extension, 2003.Search in Google Scholar

18. Ayoola PB, Adeyeye A. Phytochemical and Nutrient evaluation of Carica papaya (Pawpaw) Leaves. Int J Res Rev Appl Sci. 2010; 5 (3).Search in Google Scholar

19. Baiyewu RA, Amusa NA. The Effect of temperature and Relative Humidity on pawpaw fruit rot in South-Western Nigeria. Wr J Agric Sci. 2005; 1(1): 80-83.Search in Google Scholar

20. Chan K, Shaw D, Simmonds MS, Leon CJ, Xu Q, Lu A, Sutherland I, Ignatova S, Zhu YP, Verpoorte R, Williamson EM, Duez P. Good practice in reviewing and publishing studies on herbal medicine, with special emphasis on traditional Chinese medicine and Chinese materia medica. J Ethnopharmacol. 2012; 140(3):469-75.10.1016/j.jep.2012.01.03822330011Search in Google Scholar

21. Guisti G, Galanti B. Colorimetric method. In: Bergmeyer HU (eds) Methods of enzymatic analysis. Verlag Chemie, Weinheim, 1984; 315–323.Search in Google Scholar

22. Ben-Assayag E, Shenhar-Tsarfaty S, Bova I, et al. Triggered C-reactive protein (CRP) concentrations and the CRP gene -717A>G polymorphism in acute stroke or transient ischemic attack. Euro J Neurol. 2007; 14: 315-320.10.1111/j.1468-1331.2006.01661.x17355554Search in Google Scholar

23. Morakino AO, Adeniyi OS, Arikawe AP. Effects of Zingiber officinale on reproductive functions of the male rat. African J Biomed Res. 2008; 2:329 - 339.Search in Google Scholar

24. Varshney R, Kale RK. Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes. Int J Radia Biol. 1990; 58: 733-43.10.1080/09553009014552121Search in Google Scholar

25. Ballentine R, Burford DD. Determination of metals. Methods Enzymol. 1957; 3: 1002-1035.10.1016/S0076-6879(57)03493-XSearch in Google Scholar

26. Nain S, Smits JEG. Pathological, immunological and biochemical markers of subchronic arsenic toxicity in rats. Environ Toxicol. 2012; 27 (4):244-25410.1002/tox.2063520725942Open DOISearch in Google Scholar

27. Kitchin KT. Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol Appl Pharmacol. 2001; 172 (3): 249–261.10.1006/taap.2001.915711312654Search in Google Scholar

28. Bamisaye FA, Ajani EO, Minari JB. Prospects of Ethnobotanical Uses of Pawpaw (Carica Papaya). Journal of Medicinal Plants Studies. 2013; 1(4): 171-177Search in Google Scholar

29. Spanevello RM, Mazzanti CM, Kaizer R, et al. Apyrase and 5′-nucleotidase activities in synaptosomes from the cerebral cortex of rats experimentally demyelinated with ethidium bromide and treated with interferon-b. Neurochem Res. 2006; 31:455-62.10.1007/s11064-006-9039-516758353Open DOISearch in Google Scholar

30. Kaizer RR, Maldonado PA, Spanevello RM, et al. The effect of aluminium on NTPDase and 5′-nucleotidase activities from rat synaptosomes and platelets. Int J Dev Neurosci. 2007; 25:381-6.10.1016/j.ijdevneu.2007.06.00217686601Open DOISearch in Google Scholar

31. Schmatz R, Schetinger MRC, Spanevello RM, et al. Effects of resveratrol on nucleotide degrading enzymes in streptozotocin induced diabetic rats. Life Sci. 2009; 84:345-50.10.1016/j.lfs.2008.12.01919166862Search in Google Scholar

32. Grenz A, Zhang H, Eckle T, et al. Protective role of ecto-5′-nucleotidase (CD73) in renal ischemia. J Am Soc Nephrol. 2007; 18:833-45.10.1681/ASN.200610114117267736Open DOISearch in Google Scholar

33. Qu J, Lü X, Liu Y, et al. Evaluation of procalcitonin, Creactive protein, interleukin-6 & serum amyloid A as diagnostic biomarkers of bacterial infection in febrile patients. Ind J Med Res. 2015; 141: 315-21.10.4103/0971-5916.156617444232925963492Search in Google Scholar

34. Alghasham A, Salem TA, Meki AM. Effect of cadmium-polluted water on plasma levels of tumor necrosis factor-a, interleukin-6 and oxidative status biomarkers in rats: Protective effect of curcumin. Food Chem Toxicol. 2013; 59: 160-4.10.1016/j.fct.2013.05.05923764358Search in Google Scholar

35. Iraz M, Iraz M, Eşrefoğlu M et al. (2015) Protective effect of β-glucan on acute lung injury induced by lipopolysaccharide in rats. Turkish J Med Sci. 2015; 45: 261-7.10.3906/sag-1312-1Search in Google Scholar

36. Black PH. The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain Behavioural Immunity. 2003; 17:350–364.10.1016/S0889-1591(03)00048-5Open DOISearch in Google Scholar

37. Leemans JC, Kors L, Anders HJ, et al. Pattern recognition receptors and the inflammasome in kidney disease. Nature Reviews Nephrol. 2014; 10:398–414.10.1038/nrneph.2014.91Search in Google Scholar

38. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002; 420:860–867.10.1038/nature01322Search in Google Scholar

39. Druwe IL, Sollome JJ, Sanchez-Soria P, et al. Arsenite activates NF-kappa B through induction of C-reactive protein. Toxicol Appl Pharmacol, 2012; 261:263–270.10.1016/j.taap.2012.04.005Search in Google Scholar

40. Bounaama A, Djerdjouri B, Laroche-Clary A, et al. Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-b1 and HES-1 transcripts in 1,2-dimethylhydrazine-colon carcinogenesis in mice. Toxicol. 2012; 302:308-17.10.1016/j.tox.2012.08.014Search in Google Scholar

41. Ghasemi M, Nematbakhsh M, Daneshmand F, et al. A. Role of nitric oxide in kidney and liver (as distance organ) function in bilateral renal ischemia-reperfusion: effect of L-arginine and NG-nitro-L-arginine methyl ester. Adv Biomed Res. 2015; 4:233.Search in Google Scholar

42. Southan GJ, Szabó C. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem Pharmacol. 1996; 51 (4): 383–94.10.1016/0006-2952(95)02099-3Open DOISearch in Google Scholar

43. Yang H, Shu Y. Cadmium transporters in the kidney and cadmium-induced nephrotoxicity. Int J Mole Sci. 2015; 16:1484-94.10.3390/ijms16011484430731525584611Search in Google Scholar

44. Ojo OA, Oyinloye BE, Ajiboye BO, et al. Dichlorvos induced oxidative stress in rat brain: Protective effects of Ethanolic extract of Alstonia boonei stem bark. Asian J Pharmaceutics. 2014b; 8(4):216-22110.4103/0973-8398.143931Search in Google Scholar

45. Esrefoglu M, Gul M, Ates B, et al. Ultrastructural clues for the protective effect of ascorbic acid and N acetylcysteine against oxidative damage on caerulein induced pancreatitis. Pancreatol. 2006; 6:477-85.10.1159/00009466516864970Search in Google Scholar

46. Oyinloye BE, Ajiboye BO, Ojo OA, et al. (2016) Cardioprotective and antioxidant influence of aqueous extracts from Sesamum indicum seeds on oxidative stress induced by cadmium in Wistar rats. Pharmacog Mag. 2016; 12(46): S170-S174.10.1016/j.sajb.2016.02.148Search in Google Scholar

47. Ojo OA, Ajiboye BO, Oyinloye BE, et al. Protective Effect of Irvingia gabonensis stem bark extract on Cadmium-Induced Nephrotoxicity in rats. Interdiscip Toxicol. 2015; 7(4): 208-214.10.2478/intox-2014-0030443621026109902Search in Google Scholar

48. Miltonprabu S, Sumedha NC. Arsenic induced biochemical and genotoxic effects and its amelioration by diallyl trisulphide in rats. Int J Adv Res. 2013; 1(7): 175-184.Search in Google Scholar

eISSN:
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