<abstract xmlns="http://www.w3.org/1999/xhtml"> The nucleus accumbens is a part of the ventral striatum along with the caudate nucleus and putamen. The role of the human nucleus accumbens in drug addiction and other psychiatric disorders is of great importance. The aim of this study was to characterize medium spiny neurons in the nucleus accumbens according to the immunohistochemical expression of GAD67. This study was conducted on twenty human brains of both sexes between the ages of 20 and 75. The expression of GAD67 was assessed immunohistochemically, and the characterization of the neurons was based on the shape and size of the soma and the number of impregnated primary dendrites. We showed that neurons of the human nucleus accumbens expressed GAD67 in the neuron soma and in the primary dendrites. An analysis of the cell body morphology revealed the following four different types of neurons: fusiform neurons, fusiform neurons with lateral dendrites, pyramidal neurons and multipolar neurons. An immunohistochemical analysis showed a strong GAD67 expression in GABAergic medium spiny neurons, which could be classifi ed into four different types, and these neurons morphologically correlated with those described by the Golgi study.</abstract>

The nucleus accumbens is a part of the ventral striatum along with the caudate nucleus and putamen. The role of the human nucleus accumbens in drug addiction and other psychiatric disorders is of great importance. The aim of this study was to characterize medium spiny neurons in the nucleus accumbens according to the immunohistochemical expression of GAD67. This study was conducted on twenty human brains of both sexes between the ages of 20 and 75. The expression of GAD67 was assessed immunohistochemically, and the characterization of the neurons was based on the shape and size of the soma and the number of impregnated primary dendrites. We showed that neurons of the human nucleus accumbens expressed GAD67 in the neuron soma and in the primary dendrites. An analysis of the cell body morphology revealed the following four different types of neurons: fusiform neurons, fusiform neurons with lateral dendrites, pyramidal neurons and multipolar neurons. An immunohistochemical analysis showed a strong GAD67 expression in GABAergic medium spiny neurons, which could be classifi ed into four different types, and these neurons morphologically correlated with those described by the Golgi study.

Morphology of Human Nucleus Accumbens Neurons Based on the Immunohistochemical Expression of Gad67

Department of Histology and Embryology, Faculty of Medical Sciences, University of Kragujevac, Serbia, Svetozara Markovica 69, 34000 Kragujevac,

Department of Pathological Anatomy, Faculty of Medical Sciences, University of Kragujevac,

Department of Anatomy and Forensic medicine, Faculty of Medical Sciences, University of Kragujevac,

Department of Histology and Embryology, Faculty of Medical Sciences, University of Kragujevac,

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The nucleus accumbens is a part of the ventral striatum along with the caudate nucleus and putamen. The role of the human nucleus accumbens in drug addiction...

Morphology of Human Nucleus Accumbens Neurons Based on the Immunohistochemical Expression of Gad67

Published Online: Dec 13, 2016

Page range: 297 - 302

Received: Mar 30, 2016

Accepted: May 19, 2016

DOI: https://doi.org/10.1515/sjecr-2016-0041

Keywords
nucleus accumbens, GAD67, immunohistochemistry

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Morphology of Human Nucleus Accumbens Neurons Based on the Immunohistochemical Expression of Gad67

Published Online: Dec 13, 2016

Page range: 297 - 302

Received: Mar 30, 2016

Accepted: May 19, 2016

DOI: https://doi.org/10.1515/sjecr-2016-0041

Keywordsnucleus accumbens, GAD67, immunohistochemistry

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
nucleus accumbens, GAD67, immunohistochemistry