<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background</bold>. Subclinical hypothyroidism (sHT) is a condition defined by elevated TSH values with normal levels of free thyroid hormones. Altered metabolic status is one of the consequences of sHT which can affect serum levels of FPG, lipid profile, and nitric oxide which propounds cardiovascular consequences per se. The aim of this study was to determine the possible effects of sHT on nitrite/nitrate levels, as a marker of endothelial performance.<bold>Materials and Methods</bold>. 50 females were enrolled in this study, 25 women as control group and 25 women as case group (evaluated two times: before and after levothyroxine therapy). Blood samples were collected and levels of FPG, lipid profile components, and nitric oxide were measured spectrophotometrically. The data were analyzed using SPSS version 18 software.<bold>Results</bold>. The levels of lipid profile (except for TG between before and after group, p &lt; 0.05) and nitric oxide did not differ in groups while FPG was significantly higher in case groups in comparison to control group (p &lt; 0.001). Nitric oxide had no correlations with any of variables except for LDL in after treatment group (p &lt; 0.05 and r = 0.397).<bold>Conclusion</bold>. Nitric oxide does not have correlation with components of lipid profile (except for LDL) or FPG and has no differences in subclinical hypothyroid patients and control group. Levothyroxine therapy during 2 months cannot alter the levels of nitric oxide in subclinical hypothyroid patients.</abstract>

Background. Subclinical hypothyroidism (sHT) is a condition defined by elevated TSH values with normal levels of free thyroid hormones. Altered metabolic status is one of the consequences of sHT which can affect serum levels of FPG, lipid profile, and nitric oxide which propounds cardiovascular consequences per se. The aim of this study was to determine the possible effects of sHT on nitrite/nitrate levels, as a marker of endothelial performance.Materials and Methods. 50 females were enrolled in this study, 25 women as control group and 25 women as case group (evaluated two times: before and after levothyroxine therapy). Blood samples were collected and levels of FPG, lipid profile components, and nitric oxide were measured spectrophotometrically. The data were analyzed using SPSS version 18 software.Results. The levels of lipid profile (except for TG between before and after group, p < 0.05) and nitric oxide did not differ in groups while FPG was significantly higher in case groups in comparison to control group (p < 0.001). Nitric oxide had no correlations with any of variables except for LDL in after treatment group (p < 0.05 and r = 0.397).Conclusion. Nitric oxide does not have correlation with components of lipid profile (except for LDL) or FPG and has no differences in subclinical hypothyroid patients and control group. Levothyroxine therapy during 2 months cannot alter the levels of nitric oxide in subclinical hypothyroid patients.

Serum levels of nitrite/nitrate, lipid profile, and Fasting Plasma Glucose and their associations in subclinical hypothyroid women before and after a two month treatment by levothyroxine

Department of Biochemistry and Biophysics, Metabolic Disorders Research Center, Gorgan Faculty of Medicine

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Background. Subclinical hypothyroidism (sHT) is a condition defined by elevated TSH values with normal levels of free thyroid hormones. Altered metabolic...

Serum levels of nitrite/nitrate, lipid profile, and Fasting Plasma Glucose and their associations in subclinical hypothyroid women before and after a two month treatment by levothyroxine

Published Online: Nov 15, 2017

Page range: 205 - 211

Received: Jan 09, 2017

DOI: https://doi.org/10.1515/rjim-2017-0022

Keywords
Subclinical hypothyroid, Levothyroxine, Nitrite/nitrate, Lipid profile, Fasting plasma glucose

© 2017 Mohammad Mostakhdem Hashemi et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Serum levels of nitrite/nitrate, lipid profile, and Fasting Plasma Glucose and their associations in subclinical hypothyroid women before and after a two month treatment by levothyroxine

Published Online: Nov 15, 2017

Page range: 205 - 211

Received: Jan 09, 2017

DOI: https://doi.org/10.1515/rjim-2017-0022

KeywordsSubclinical hypothyroid, Levothyroxine, Nitrite/nitrate, Lipid profile, Fasting plasma glucose

© 2017 Mohammad Mostakhdem Hashemi et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Subclinical hypothyroid, Levothyroxine, Nitrite/nitrate, Lipid profile, Fasting plasma glucose