In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

1. Alessio E: Synthesis and reactivity of Ru-, Os-, Rh-, and Ir-Halide−Sulfoxide complexes. Chem Rev 2004, 104: 4203-4242.10.1021/cr030729115352790Search in Google Scholar

2. Kandioler W, Hartinger CG, Nazarov AA, Kasser J, John R, Jakupec MA, Arion VB, Dyson PJ, Keppler BK: Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety. J Organomet Chem 2009, 694: 922-929.10.1016/j.jorganchem.2008.10.016Search in Google Scholar

3. Singh AK, Pandey DS, Xu Q, Braunstein P: Recent advances in supramolecular and biological aspects of arene ruthenium(II) complexes. Coord Chem Rev 2014, 270-271: 31-56.10.1016/j.ccr.2013.09.009Search in Google Scholar

4. Martin EK, Pagano N, Sherlock ME, Harms K, Meggers E: Synthesis and anticancer activity of ruthenium half-sandwich complexes comprising combined metal centrochirality and planar chirality. Inorg Chim Acta 2014, 423: 530-539.10.1016/j.ica.2014.08.057Search in Google Scholar

5. Nascimento FB, Poelhsitz GV, Pavan FR, Sato DN, Leite CQO, Selistre-Araujo HS, Ellena J, Castellano EE, Deflon VM, Batista AA: Synthesis, characterization, X-ray structure and in vitro antimycobacterial andantitumoral activities of Ru(II) phosphine/diimine complexes containing the ‘‘SpymMe2” ligand, SpymMe2 = 4,6-dimethyl-2-mercaptopyrimidine. J Inorg Biochem 2008, 102: 1783-1789.10.1016/j.jinorgbio.2008.05.00918614238Search in Google Scholar

6. Nakabayashi Y, Nakamura H, Kubota Y, Morimoto M, Kawasaki T, Nakai M, Yamauchi O: DNA interaction with dipolar ruthenium(II) ammine complexes containing 4,40-bipyridinium as photochemotherapeutic agents. Inorg Chim Acta 2014, 423: 109-114.10.1016/j.ica.2014.07.071Search in Google Scholar

7. Barbosa MIF, Correa RS, Pozzi LV, Lopes EO, Pavan FR, Leite CQF, Ellena J, Machado SP, Poelhsitz G, Batista AA: Ruthenium(II) complexes with hydroxypyridinecarboxylates: Screening potential metallodrugs against Mycobacterium tuberculosis. Polyhedron 2015, 85: 376-382.10.1016/j.poly.2014.08.057Search in Google Scholar

8. Lima AP, Pereira FC, Almeida MAP, Mello FMS, Pires WC, Pinto TM, Delella FK, Felisbino SL, Moreno V, Batista AA, Silveira-Lacerda EP: Cytoxicity and apoptotic mechanism of ruthenium(II) amino acid complexes in sarcoma-180 tumor cells. PLOS ONE 2014, 10: e105865.10.1371/journal.pone.0105865420145625329644Search in Google Scholar

9. Lei X, Su W, Li P, Xiao Q, Huang S, Qian Q, Huang C, Qin D, Lan H: Ruthenium(II) arene complexes of curcuminoids: Synthesis, X-ray diffraction structure and cytotoxicity. Polyhedron 2014, 81: 614-618.10.1016/j.poly.2014.07.019Search in Google Scholar

10. Aman F, Hanif M, Siddiqui WA, Ashraf A, Filak LK, Reynisson J, Soohnel T, Jamieson SMF, Hartinger CG: Anticancer ruthenium(η6-p-cymene) complexes of nonsteroidal antiinflammatory drug derivatives. Organometallics 2014, 33: 5546-5553.10.1021/om500825hSearch in Google Scholar

11. Jakupec MA, Galanski M, Arion VB, Hartinger CG, Keppler BK: Antitumour metal compounds: more than theme and variations. Dalton Trans 2008, 183-194.10.1039/B712656PSearch in Google Scholar

12. Paula MMS, Pich CT, Petronilho F, Drei LB, Rudnicki M, Oliveira MR, Moreira JCF, Henriques JAP, Franco CV, Pizzol FD: Antioxidant activity of new ruthenium compounds. Redox Report 2005, 10: 139-143.10.1179/135100005X38897Search in Google Scholar

13. Ejidike PI, Ajibade AP: Synthesis, characterization, and in vitro antioxidant and anticancer studies of ruthenium(III) complexes of symetric and asymetric tetradentate Schiffbases. J Coord Chem 2015, 68: 2552-2564.10.1080/00958972.2015.1043127Search in Google Scholar

14. Bergamo A, Tiedel T, Dyson PJ, Sava G: Preclinical combination therapy of the investigational drug NAMI-A+ with doxorubicin for mammary cancer. Invest New Drugs 2015, 33: 53-63.10.1007/s10637-014-0175-5Search in Google Scholar

15. Aitken JB, Antony S, Weekley CM, Lai B, Spicciad L, Harris HH: Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells. Metallomics 2012, 4: 1051-1056.10.1039/c2mt20072dSearch in Google Scholar

16. Hanif M, Nawaz MAH, Babak MV, Iqbal J, Roller A, Keppler BK, Hartinger CG: RutheniumII(η6-arene) complexes of thiourea derivatives: synthesis, characterization and urease inhibition. Molecules 2014, 19: 8080-8092.10.3390/molecules19068080Search in Google Scholar

17. Creczynski-Pasa TB, Bonetti VR, Beirith A, Ckless K, Konzen M, Seifriz I, Paula MS, Franco CV, Filho DW, Calixto JB: Complexes trans-[RuCl2(nic)4] and trans-[RuCl2(i-nic)4] as free radical scavengers. J Inorg Biochem 2001, 86: 587-594.10.1016/S0162-0134(01)00222-7Search in Google Scholar

18. Victor EG, Zanette F, Aguiar MR, Aguiar CS, Cardoso DC, Cristiano MP, Streck EL, Paula MMS: Effect of ruthenium complexes on the activities of succinate dehydrogenase and cytochrome oxidase. Chem Biol Interact 2007, 170: 59-63.10.1016/j.cbi.2007.07.00117707358Search in Google Scholar

19. Almeida WLC, Vitor DN, Pereira MRG, De Sa DS, Alvarez LDG, Pinheiro AM, Costa SL, Costa MFD, Da Rocha ZN, El-Bacha RS: Redox properties of ruthenium complex with catecholare involved in toxicity to glial cells. J Chil Chem Soc 2007, 52: 1240-1243. 10.4067/S0717-97072007000300010Search in Google Scholar

20. Koukourakis MI, Giatromanolaki A, Sivridis E: Lactate dehydrogenase isoenzymes 1 and 5: Differential expression by neoplastic and stromal cells in non-small cell lung cancer and other epithelial malignant tumors. Tumor Biol 2003, 24: 199-202.10.1159/00007443014654714Search in Google Scholar

21. Thornburg JM, Nelson KK, Clem BF, Lane AN, Arumugam S, Simmons A, Eaton JW, Telang S, Chesney J: Targeting aspartate aminotransferase in breast cancer. Breast Canc Res 2008, 10: R84.10.1186/bcr2154Search in Google Scholar

22. Mishra L, Singh AK, Trigun SK, Singh SK, Pandey SM: Anti-HIV and cytotoxic ruthenium(II) complexes containing fl avones: Biochemical evaluation in mice. Indian J Exp Biol 2004, 42: 660-666.Search in Google Scholar

23. Koiri RK, Trigun SK, Mishra L, Pandey P, Dixit D, Dubey SK: Regression of Dalton’s lymphoma in vivo via decline in lactate dehydrogenase and induction of apoptosis by a ruthenium(II)-complex containing 4-carboxy-N-ethylbenzamide as ligand. Invest New Drugs 2009, 27: 503-516.10.1007/s10637-008-9202-8Search in Google Scholar

24. Martinez-Moreno P, Nieto-Ceron S, Ruiz-Espejo F, Torres-Lanzas J, Tovar-Zapata I, Martinez-Hernandez P, Vidal CJ, Cabezas-Herrera J: Acetylcholinesterase biogenesis is impaired in lung cancer tissues. Chem-Biol Interact 2005, 157-158: 359-361.10.1016/j.cbi.2005.10.050Search in Google Scholar

25. Xi Q, Gao N, Zhang X, Zhang B, Ye W, Wu J, Zhang X: A natural antisense transcript regulates acetylcholinesterase geneexpression via epigenetic modification in Hepatocellular Carcinoma. Int J Biochem & Cell B 2014, 55: 242-251.10.1016/j.biocel.2014.09.012Search in Google Scholar

26. Pervin M, Hasnat MA, Lee YM, Kim DH, Jo JE, Lim BO: Antioxidant activity and acetylcholinesterase inhibition of grape skin anthocyanin (GSA). Molecules 2014, 19: 9403-9418.10.3390/molecules19079403Search in Google Scholar

27. Berson A, Knobloch M, Hanan M, Diamant S, Sharoni M, Schuppli D, Geyer BC, Ravid R, Mor TS, Nitsch RM, Soreq H: Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology. Brain 2008, 131: 109-119.10.1093/brain/awm276Search in Google Scholar

28. Allardyce CS, Dyson PJ, Ellis DJ, Salter PA, Scopelitti R: Synthesis and characterisation of some water soluble ruthenium(II)arene complexes and an investigation of their antibiotic and antiviral properties. J Organomet Chem 2003, 668: 35-42.10.1016/S0022-328X(02)01926-5Search in Google Scholar

29. Kroener R, Heeg MJ, Deutsch E: Synthesis and characterization of polypyridine ruthenium(II) complexes containing S-bonded thioether ligands. X-ray crystal structures of cis- and trans-bis(2,2’-bipyridine)bis(phenothiazine-S)ruthenium(II)hexafl uorophosphates. Inorg Chem 1988, 27: 558-560.10.1021/ic00276a024Search in Google Scholar

30. Zhang X, Xie Y, Yu W, Zhao Q, Jiang M, Tian Y: Formation of a novel 1D supramolecule [HgCl2(ptz)]2·HgCl2 (ptz = phenothiazine): a new precursor to submicrometer Hg2Cl2 Rods. Inorg Chem 2003, 42: 3734-3737.10.1021/ic034055oSearch in Google Scholar

31. Kidd SE, Hambley TW, Hever A, Nelson MJ, Molnar J: The antiplasmid action of some palladium(II) complexes of phenothiazine based pharmaceuticals and the crystal structure of protonated trichloro [10-(3’-dimethylaminopropyl)phenothiazine-S]-palladium(II). J Inorg Biochem 1996, 6: 171-181.10.1016/0162-0134(95)00145-XSearch in Google Scholar

32. Ma L, Zhang J, Cai R, Chen Z, Weng L, Zhou X: Synthesis and reactivity of organolanthanide complexes containing phenothiazine ligand toward carbodiimide and isothiocyanate. J Organomet Chem 2005, 690: 4926-4932.10.1016/j.jorganchem.2005.08.005Search in Google Scholar

33. Keshavan B, Gowda K: Synthesis of square-planar palladium(II) and platinum(II) complexes with N-alkylphenothiazines. J Indian Chem Soc 2001, 78: 37-38.Search in Google Scholar

34. Keshavan B, Chandrashekara PG, Gowda NMM: Synthesis, characterization, and spectral studies of lanthanide(III) nitrate complexes of promethazine. J Mol Struc 2000, 553: 193-197. 10.1016/S0022-2860(00)00551-2Search in Google Scholar

35. Krstić M, Sovilj SP, Grgurić-Šipka S, Radosavljević Evans I, Borozan S, Santibanez JF, Kocić J: New ruthenium(II) complexes with N-alkylphenothiazines: synthesis, structure, in vivo activity as free radical scavengers and in vitro cytotoxycity. Eur J Med Chem 2010, 45: 3669-3676.10.1016/j.ejmech.2010.05.013Search in Google Scholar

36. Krstić M, Sovilj SP, Grgurić-Šipka S, Radosavljević Evans I, Borozan S, Santibanez JF: Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines. Eur J Med Chem 2011, 46: 4168-4177.10.1016/j.ejmech.2011.06.019Search in Google Scholar

37. Ellman GL, Courtney KD, Andres Jr V, Featherstone RM: A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961, 7: 88-95.10.1016/0006-2952(61)90145-9Search in Google Scholar

38. McQueen MJ: Optimal assay of LDH and α-HBD at 37 ºC. Ann Clin Biochem 1972, 9: 21-25.10.1177/000456327200900102Search in Google Scholar

39. Yoshida M, Takakuwa Y: Method for the simultaneous assay of initial velocities of lactate dehydrogenase isoenzymes following gel electrophoresis. J Biochem Bioph Meth 1997, 34: 167-175.10.1016/S0165-022X(97)00012-2Search in Google Scholar

40. Scion Corp., http//scioncorp.com (June, 2007.)Search in Google Scholar

41. Quinn DM: Acetylcholinesterase: Enzyme Structure, Reaction Dynamics and Virtual Transition States. Chem Rev 1987, 87: 955-979.10.1021/cr00081a005Search in Google Scholar

42. Naik P: Biochemistry, fourth ed. 2016, Japee Brothers Medical Publishers (P) LTD.Search in Google Scholar

43. Hasković E, Pekić M, Fočak M, Suljević D, Mešalić L: Effects of glyphosate on enzyme activity and serum glucose in rats. Acta Vet-Beograd 2016, 66: 214-221.10.1515/acve-2016-0018Search in Google Scholar

44. Koiri RK, Trigun SK, Dubey SK, Singh S, Mishra L: Metal Cu(II) and Zn(II) bipyridyls as inhibitors of lactate dehydrogenase. Biometals 2008, 21: 117-126. 10.1007/s10534-007-9098-317541766Search in Google Scholar