<abstract xmlns="http://www.w3.org/1999/xhtml"> The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH1 and LDH2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro- and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity.</abstract>

The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH1 and LDH2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro- and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity.

In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

Department of Chemistry, Faculty of Veterinary Medicine, University of Belgrade, Bulevar oslobodjenja 18, 11000 Belgrade,

Deparment of General and Inorganic Chemistry, Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade,

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines"}

The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme...

In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

Published Online: Dec 30, 2016

Page range: 497 - 508

Received: Sep 09, 2016

Accepted: Nov 15, 2016

DOI: https://doi.org/10.1515/acve-2016-0043

Keywords
Ruthenium complexes, N-alkylphenothiazines, Acethylcholinesterase, Lactate dehydrogenase

© by Milena Krstić P.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

Published Online: Dec 30, 2016

Page range: 497 - 508

Received: Sep 09, 2016

Accepted: Nov 15, 2016

DOI: https://doi.org/10.1515/acve-2016-0043

KeywordsRuthenium complexes, N-alkylphenothiazines, Acethylcholinesterase, Lactate dehydrogenase

© by Milena Krstić P.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Ruthenium complexes, N-alkylphenothiazines, Acethylcholinesterase, Lactate dehydrogenase