<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Non-alcoholic fatty liver disease (NAFLD) has been defined as a spectrum of histological abnormalities and is characterized by significant and excessive accumulation of triglycerides in the hepatocytes in patients without alcohol consumption or other diseases. Current studies are targeting new molecular mechanisms that underlie NAFLD and associated metabolic disorders. Many therapeutic targets have been found and used in clinical studies. Peroxisome proliferator-activated receptors (PPARs) are among the potential targets and have been demonstrated to exert a pivotal role in modulation of NAFLD. Many drugs developed so far are targeted at PPARs. Thus, the aim of this paper is to summarize the roles of PPARs in the treatment of NAFLD.</p></abstract>

Non-alcoholic fatty liver disease (NAFLD) has been defined as a spectrum of histological abnormalities and is characterized by significant and excessive accumulation of triglycerides in the hepatocytes in patients without alcohol consumption or other diseases. Current studies are targeting new molecular mechanisms that underlie NAFLD and associated metabolic disorders. Many therapeutic targets have been found and used in clinical studies. Peroxisome proliferator-activated receptors (PPARs) are among the potential targets and have been demonstrated to exert a pivotal role in modulation of NAFLD. Many drugs developed so far are targeted at PPARs. Thus, the aim of this paper is to summarize the roles of PPARs in the treatment of NAFLD.

The role of peroxisome proliferator-activated receptor in the treatment of non-alcoholic fatty liver disease

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Non-alcoholic fatty liver disease (NAFLD) has been defined as a spectrum of histological abnormalities and is characterized by significant and excessive...

The role of peroxisome proliferator-activated receptor in the treatment of non-alcoholic fatty liver disease

Article Category: Review

Published Online: Feb 21, 2017

Page range: 1 - 13

Accepted: Oct 06, 2016

DOI: https://doi.org/10.1515/acph-2017-0007

Keywords
non alcoholic fatty liver disease, peroxisome proliferator activated receptors, agonists, insulin resistance, inflammation

© by Yan Zhang

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The role of peroxisome proliferator-activated receptor in the treatment of non-alcoholic fatty liver disease

Article Category: Review

Published Online: Feb 21, 2017

Page range: 1 - 13

Accepted: Oct 06, 2016

DOI: https://doi.org/10.1515/acph-2017-0007

Keywordsnon alcoholic fatty liver disease, peroxisome proliferator activated receptors, agonists, insulin resistance, inflammation

© by Yan Zhang

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
non alcoholic fatty liver disease, peroxisome proliferator activated receptors, agonists, insulin resistance, inflammation