Antibiotic(s) | Group | No. | HA | HAC | Calculated by subtraction of the mean HAC from the mean HA: | HAR Calculated by dividing the amount of HAC by the amount of HA: HAR = HAC/HA | Suitability to each criterion All 3 criteria (C1–C3) suggest the contribution of efflux activity to antibiotic resistance. Criterion 1 is a significant difference in the mean HAR between the susceptible group and non-susceptible group for an antibiotic. Criterion 2 is a mean HA in the non-susceptible group that is lower than that in the susceptible group for an antibiotic. Criterion 3 is a mean HA that is lower than the mean HAC in the non-susceptible group for an antibiotic. 1 means the criterion is met. 0 means the criterion is not met | |||||||||
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Mean | SD | Mean | SD | Mean | SD | C1 | C2 | C3 | AC | |||||||
Cefepime | Susceptible | 19 | 742.1 | 223.1 | 0.028 | 685.1 | 164.9 | 0.447 | 57.03 | 0.9 | 0.2 | 0.000 | 1 | 1 | 1 | 1 |
Non-susceptible | 101 | 607.5 | 245.4 | 655.3 | 154.4 | –47.81 | 1.2 | 0.5 | ||||||||
Cefotaxime | Susceptible | 17 | 740.8 | 242.0 | 0.042 | 696.9 | 172.5 | 0.295 | 43.94 | 1.0 | 0.3 | 0.010 | 1 | 1 | 1 | 1 |
Non-susceptible | 103 | 610.4 | 243.0 | 654.0 | 152.8 | –43.61 | 1.2 | 0.5 | ||||||||
Ceftazidime | Susceptible | 19 | 742.1 | 223.1 | 0.028 | 685.1 | 164.9 | 0.447 | 57.03 | 0.9 | 0.2 | 0.000 | 1 | 1 | 1 | 1 |
Non-susceptible | 101 | 607.5 | 245.4 | 655.3 | 154.4 | –47.81 | 1.2 | 0.5 | ||||||||
Imipenem | Susceptible | 20 | 726.4 | 228.3 | 0.052 | 690.4 | 162.2 | 0.342 | 36.00 | 1.0 | 0.3 | 0.004 | 1 | 1 | 1 | 1 |
Non-susceptible | 100 | 609.3 | 246.0 | 654.0 | 154.5 | –44.65 | 1.2 | 0.5 | ||||||||
Meropenem | Susceptible | 20 | 726.4 | 228.3 | 0.052 | 690.4 | 162.2 | 0.342 | 36.00 | 1.0 | 0.3 | 0.004 | 1 | 1 | 1 | 1 |
Non-susceptible | 100 | 609.3 | 246.0 | 654.0 | 154.5 | –44.65 | 1.2 | 0.5 | ||||||||
Piperacillin | Susceptible | 20 | 726.4 | 228.3 | 0.052 | 690.4 | 162.2 | 0.342 | 36.00 | 1.0 | 0.3 | 0.004 | 1 | 1 | 1 | 1 |
Non-susceptible | 100 | 609.3 | 246.0 | 654.0 | 154.5 | –44.65 | 1.2 | 0.5 | ||||||||
Piperacillin/tazobactam | Susceptible | 20 | 726.4 | 228.3 | 0.052 | 690.4 | 162.2 | 0.342 | 36.00 | 1.0 | 0.3 | 0.004 | 1 | 1 | 1 | 1 |
Non-susceptible | 100 | 609.3 | 246.0 | 654.0 | 154.5 | –44.65 | 1.2 | 0.5 | ||||||||
Ticarcillin/clavulanic acid | Susceptible | 20 | 726.4 | 228.3 | 0.052 | 690.4 | 162.2 | 0.342 | 36.00 | 1.0 | 0.3 | 0.004 | 1 | 1 | 1 | 1 |
Non-susceptible | 100 | 609.3 | 246.0 | 654.0 | 154.5 | –44.65 | 1.2 | 0.5 | ||||||||
Ampicillin/sulbactam | Susceptible | 25 | 675.4 | 237.5 | 0.289 | 694.4 | 169.0 | 0.216 | –19.00 | 1.1 | 0.4 | 0.387 | 0 | 1 | 1 | 0 |
Non-susceptible | 95 | 616.6 | 248.1 | 651.0 | 151.7 | –34.42 | 1.2 | 0.5 | ||||||||
Aztreonam | Susceptible | 1 | 487.5 | NA | 485.1 | NA | 2.34 | 1.0 | NA | 0 | 0 | 1 | 0 | |||
Non-susceptible | 119 | 630.0 | 246.9 | 661.5 | 155.5 | –31.49 | 1.2 | 0.5 | ||||||||
Tigecycline | Susceptible | 31 | 732.0 | 236.9 | 0.006 | 666.1 | 164.7 | 0.804 | 65.92 | 1.0 | 0.2 | 0.000 | 1 | 1 | 1 | 1 |
Non-susceptible | 89 | 592.9 | 240.3 | 657.9 | 153.4 | –65.04 | 1.3 | 0.5 | ||||||||
Minocycline | Susceptible | 111 | 636.7 | 250.5 | 0.219 | 656.3 | 147.7 | 0.555 | –19.56 | 1.2 | 0.5 | 0.200 | 0 | 1 | 1 | 0 |
Non-susceptible | 9 | 531.6 | 164.6 | 706.5 | 241.5 | –174.84 | 1.4 | 0.4 | ||||||||
Ciprofloxacin | Susceptible | 19 | 742.1 | 223.1 | 0.028 | 685.1 | 164.9 | 0.447 | 57.03 | 0.9 | 0.2 | 0.000 | 1 | 1 | 1 | 1 |
Non-susceptible | 101 | 607.5 | 245.4 | 655.3 | 154.4 | –47.81 | 1.2 | 0.5 | ||||||||
Gentamicin | Susceptible | 25 | 700.5 | 218.8 | 0.102 | 682.8 | 156.7 | 0.414 | 17.70 | 1.0 | 0.2 | 0.002 | 1 | 1 | 1 | 1 |
Non-susceptible | 95 | 610.0 | 250.5 | 654.0 | 155.7 | –44.08 | 1.2 | 0.5 | ||||||||
Colistin | Susceptible | 119 | 626.6 | 246.0 | NA | 660.9 | 156.1 | NA | –34.25 | 1.2 | 0.5 | NA | 0 | 0 | 0 | 0 |
Non-susceptible | 1 | 893.5 | 563.1 | 330.33 | 0.6 | |||||||||||
Trimethoprim/sulfamethoxazole | Susceptible | 31 | 628.2 | 238.9 | 0.979 | 684.4 | 165.3 | 0.276 | –56.23 | 1.2 | 0.4 | 0.767 | 0 | 0 | 1 | 0 |
Non-susceptible | 88 | 629.6 | 251.3 | 649.0 | 151.2 | –19.39 | 1.2 | 0.5 | ||||||||
Multidrug resistance | Non-MDR | 20 | 726.4 | 228.3 | 0.052 | 690.4 | 162.2 | 0.342 | 36.00 | 1.0 | 0.3 | 0.004 | 1 | 1 | 1 | 1 |
MDR | 100 | 609.3 | 246.0 | 654.0 | 154.5 | –44.65 | 1.2 | 0.5 |