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Asian Biomedicine
Volume 10 (2016): Issue 4 (August 2016)
Open Access
Immunotherapeutic efficacy of a
Lactobacillus casei
lysate as an adjuvant combined with a heated-4T1 mammary carcinoma cell lysate in a murine model of breast cancer
Ruhollah Dorostkar
Ruhollah Dorostkar
,
Mohammad Sadegh Hashemzadeh
Mohammad Sadegh Hashemzadeh
,
Sajjad Jafari
Sajjad Jafari
,
Mahdi Tat
Mahdi Tat
,
Majdedin Ghalavand
Majdedin Ghalavand
,
Mohammad Hossein Asghari
Mohammad Hossein Asghari
and
Milad Moloudizargari
Milad Moloudizargari
| Jan 31, 2017
Asian Biomedicine
Volume 10 (2016): Issue 4 (August 2016)
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Article Category:
Original article
Published Online:
Jan 31, 2017
Page range:
327 - 334
DOI:
https://doi.org/10.5372/1905-7415.1004.494
Keywords
Cancer immunotherapy
,
HSP
,
TNF-α
,
tumor
,
vaccine
© 2016 Ruhollah Dorostkar, Mohammad Sadegh Hashemzadeh, Sajjad Jafari, Mahdi Tat, Majdedin Ghalavand, Mohammad Hossein Asghari, Milad Moloudizargari
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Figure 1
Comparison of lung weight (upper left), tumor necrosis factor (TNF)-α levels (upper right), tumor size (lower left), and tumor weight (lower right), and after immunization with a heated-4T1-cell lysate alone (hatched bar), the L. casei lysate alone (open bar), and their combination (crosshatchedbar). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P< 0.0001.
Figure 2
Levels of IL-2 (upper left), IL-12 (upper right), IL-13 (lower left), and IL-17 (lower right) after immunization with a heated-4T1-cell lysate alone (hatched bar), the L. casei lysate alone (open bar), and their combination (crosshatchedbar). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.