Hyponatraemia and syndrome of inappropriate antidiuretic hormone secretion in non-azotaemic dogs with babesiosis associated with decreased arterial blood pressure

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Abstract

Introduction

A previous study on canine babesiosis showed low serum tonicity in affected dogs, which may result from syndrome of inappropriate antidiuretic hormone secretion (SIADH). This endocrine disorder was recognised in human malaria which is considered a disease with similar pathogenesis to canine babesiosis. The aim of this study was to investigate the occurrence of SIADH in babesiosis-afflicted dogs.

Material and Methods

Serum and urinary sodium and urine specific gravity (USG) were determined in dogs with babesiosis. Mean arterial pressure (MAP) was measured at the beginning of the clinical examination. Serum tonicity and osmolality were calculated. Correlations were calculated between MAP and serum and urinary sodium concentrations, USG, serum tonicity, and calculated serum osmolality.

Results

Statistically significant correlations were observed between MAP and tonicity, calculated osmolality, USG, and serum and urinary sodium concentrations in non-azotaemic dogs. In three non-azotaemic dogs SIADH was recognised.

Conclusion

SIADH develops in non-azotaemic dogs with babesiosis. It is probably associated with decreased blood pressure in infected dogs. Thus, it seems that in fact it may be appropriate vasopressin secretion in canine babesiosis as a protective mechanism in hypotension which leads to hypoxia and renal failure in affected dogs.

Introduction

Canine babesiosis is a tick-borne protozoan disease caused by parasites of the genus Babesia. The disease may be caused by infection with small species of the parasite such as B. gibsoni, B. conradae, or B. vulpes, or large species such as B. canis, B. vogeli, or B. rossi (4, 17, 20). In dogs from Poland, only B. canis has been detected (2, 34, 40). Infection with the parasite may lead to systemic inflammatory response syndrome, multiple organ dysfunction syndrome, and septic shock, and the disease is considered similar to human malaria which is caused by infection with mosquito-borne parasites of the genus Plasmodium (8, 23). Both infections are classified as protozoal sepsis, and pathogenesis in both diseases is associated with overproduction of pro-inflammatory cytokines (8, 12, 37, 38). Moreover, in both diseases hypotension was observed, which is defined in dogs as mean arterial pressure lower than 80 mmHg (8, 23). One study on human malaria showed release of antidiuretic hormone (ADH, also known as vasopressin) leading to hyponatraemia in patients with decreased blood pressure (14). The role of ADH in human malaria is not clear. Studies on vasopressin in human malaria showed both appropriate and inappropriate ADH secretion (14, 15, 16).

Hyponatraemia was also observed in dogs infected with B. rossi and B. canis, and syndrome of inappropriate antidiuretic hormone (SIADH) secretion in infected dogs was suggested in a previous study on canine babesiosis (1, 21, 39). SIADH is a disorder of sodium and water balance. The syndrome leads to hyponatraemia, hypotonicity (decreased effective extracellular fluid osmolality), and impaired urinary dilution (9, 11). In humans, the first two cases of SIADH were described in 1957 by Schwartz et al. (28), and SIADH is also known as Schwartz-Bartter syndrome or syndrome of inappropriate antidiuresis. Hypersecretion of ADH not being observed in all patients with the syndrome, diagnosis of SIADH does not require vasopressin determination (11). The criteria for SIADH in humans are as follows: hyponatraemia, hypotonicity (tonicity lower than 280 mOsm/kg, but according to some authors <275 mOsm/kg means true hyponatraemia; strong correlation with serum hypoosmolality), high urine osmolality (strongly correlated with high specific gravity), lack of clinical signs of hypovolaemia, high urinary sodium concentration (higher than 30 mEq/L), no detection of renal insufficiency, hypothyroidism, or hypocorticism, and no recent use of thiazide diuretics (9, 24).

SIADH in humans may result from eutopic or ectopic secretion of ADH, and it has been recognised in neoplastic diseases (e.g. bronchogenic carcinoma or leukaemia), lung diseases (e.g. pneumonia or asthma), cerebral diseases (e.g. meningitis or encephalitis), and infectious diseases (e.g. AIDS, tuberculosis, or malaria). Moreover, SIADH may be iatrogenic (from the use of vasopressin or its analogues), nephrogenic (from mutations of vasopressin receptor genes), or idiopathic. Other causes of SIADH in humans include pain (especially post-operative), severe nausea, and stress (11, 15). In dogs, SIADH has been recognised in only a few animals of various breeds and both sexes, and it was concurrent to aspiration pneumonia, liver disease, granulomatous amoebic meningoencephalitis, congenital hydrocephalus, and histiocytic sarcoma (5, 6, 7, 19, 22, 29). SIADH in dogs may also be idiopathic as in humans and this was diagnosed in two dogs (25).

Owing to the facts that babesiosis and malaria are similar diseases, hyponatraemia was noted in both, and SIADH was diagnosed in human malaria, the authors of this study hypothesised that SIADH may also occur in canine babesiosis.

Material and Methods

Thirty-six serum, whole blood, and urine samples were collected from dogs of various breeds naturally infected with Babesia canis but yet to be treated (Group A). Fifteen healthy dogs of various breeds (seven mixed-breed dogs, two Labradors, one Dachshund, one Beagle, one Golden Retriever, one Jack Russell Terrier, one Siberian Husky, and one German Shepherd) comprising eight males and seven females of one to seven years of age were used as the control group (Group B). Two types of tubes were used for the blood collection: tubes coated with EDTA for whole blood samples and dry tubes for serum samples. Urine samples were collected in dry plastic containers. Initial diagnosis of infection was based on the result of blood smear examinations. Confirmations of the infection with B. canis and freedom from infection with Anaplasma phagocytophilum, the second most prevalent tick-borne canine pathogen in Poland, were based on the results of the PCR methods described in previous studies (26, 33, 39).

Clinical examination (including blood pressure measurement) was performed during the visit before sample collection. Mean arterial pressure was measured using the oscillometric technique with a Cardell 9405 veterinary monitor (Midmark, USA). Serum and urine sodium concentrations were determined by a Rapidchem 744 clinical chemistry analyser (Siemens Healthcare Diagnostics, Germany).

Before determination of urinary sodium concentration, urine samples were centrifuged (2,000 rpm, 5 min) and then supernatant fluid was diluted tenfold in deionised water. Serum and urine concentrations of creatinine and serum urea and glucose content were assayed by an XL 640 clinical chemistry analyser (Erba Mannheim, Germany). Urine specific gravity (USG) was read using a Reichert VET 360 veterinary refractometer (Reichert, USA). These parameters were used to derive effective extracellular fluid (ECF) osmolality (tonicity), calculated osmolality, and the renal failure index. Effective ECF osmolality was calculated according to Wellman et al. (35) using the formula Eff. ECF Osm. = 2 × SNa+ (mEq/L) + glucose (mg/dL)/18, where SNa+ is serum sodium concentration and milliequivalent weight is millimolar weight multiplied by the valence (mEq/L = mmol/L × valence). Calculated osmolality was yielded by the formula Calc. Osm. = tonicity (mOsm/kg) + BUN (mg/dL)/2.8, where BUN is concentration of blood urea nitrogen. The calculation of BUN required the serum urea concentration and used the formula BUN = serum urea concentration/2.14 (10). The renal failure index (RFI) was calculated according to Waldrop (32) using the formula RFI = UNa+ × SCr/UCr, where UNa+ is urinary sodium concentration, SCr is serum creatinine concentration, and UCr is urinary creatinine concentration.

Exclusion criteria were as follows: data supporting the suspicion of hypothyroidism, adrenal disease or renal disease (in group A before infection), and recent use of diuretics. Moreover, all infected dogs with clinical signs such as vomiting, diarrhoea, dehydration, ascites, oedema, and RFI > 2 indicating renal injury were excluded from the study.

Obtained results guided the division of group A into two subgroups: A1, of azotaemic dogs and A2, of non-azotaemic dogs. The results were analysed using the Statistica 13.3 programme (Tibco Software, USA). The Shapiro–Wilk W-test was used for the estimation of normality in the distributions of concentrations of urinary and serum sodium, effective ECF osmolality, urine specific gravity, and mean arterial pressure in groups A and B and subgroups A1 and A2. Depending on the normality of distributions, Spearman’s rank correlation coefficient (other than normal distribution) or Pearson’s correlation coefficient (normal distribution) was used to calculate correlations between MAP and serum and urinary sodium concentrations, USG, serum tonicity, and calculated serum osmolality in groups A and B and subgroups A1 and A2.

Results

Among 36 infected animals (group A), 15 dogs had azotaemia (mean serum creatinine concentration 3.51 ± 1.85 mg/dL and mean serum urea concentration 245.5 ± 121.4 mg/dL), and 21 dogs had no azotaemia (subgroup A2: mean serum creatinine concentration 1.09 ± 0.30 mg/dL and mean serum urea concentration 39.7 ± 7.8 mg/dL). However, seven azotaemic dogs were excluded from the study owing to RFI > 2 indicating renal azotaemia and corroborating clinical signs such as vomiting, diarrhoea and dehydration in these animals. Mean serum creatinine and urea concentrations in subgroup A1 (azotaemic dogs after exclusion of the seven dogs with renal azotaemia) were as follows: mean serum creatinine concentration 2.37 ± 0.42 mg/dL and mean serum urea concentration 165.7 ± 55.2 mg/dL. None of the dogs in this study had signs of hypothyroidism, adrenal or renal disease before the infection, and none of them had been treated with diuretics recently. A PCR assay confirmed infection with B. canis in all 29 infected dogs included in the study. No dogs were infected with A. phagocytophilum.

The Shapiro–Wilk W-test for normality in urinary and serum sodium, effective ECF osmolality, calculated osmolality, urine specific gravity, and mean arterial pressure showed a non-normal distribution in USG and MAP in group A and subgroup A2 (Table 1).

Table 1

Results of the Shapiro–Wilk W-test for normality in groups A and B and subgroups A1 and A2 in the distribution of effective ECF osmolality, calculated osmolality, serum sodium concentration, urinary sodium concentration, urine specific gravity, and mean arterial pressure

ParameterGroupWp
Effective ECF osmolalityA0.9680.532
B0.9640.769
A10.9710.910
A20.9570.469
Calculated osmolalityA0.9540.243
B0.9840.989
A10.8910.239
A20.9440.263
Serum Na+A0.9660.465
B0.9590.690
A10.9470.681
A20.9580.486
Urinary Na+A0.9520.214
B0.9880.998
A10.9620.825
A20.9530.363
USGA0.9190.029*
B0.9340.309
A10.8530.104
A20.9020.039*
MAPA0.8490.001*
B0.9760.939
A10.8920.245
A20.8560.005*
ECF – extracellular fluid, Serum Na+ – serum sodium concentration, Urinary Na+ – urinary sodium concentration, USG – urine specific gravity, MAP – mean arterial pressure, W – value of W in the Shapiro–Wilk W-test, p – value of p, * – p < 0.05

In groups A and B and subgroup A1, there were no statistically significant correlations between MAP and effective ECF osmolality, calculated osmolality, serum and urinary sodium concentrations, or urine specific gravity. Statistically significant positive correlations were observed between MAP and tonicity, calculated osmolality, and serum sodium concentration in subgroup A2. Statistically significant negative correlations were observed between MAP and urinary sodium concentration and USG (Table 2).

Table 2

Statistically significant correlations between mean arterial pressure and effective ECF osmolality (Eff. ECF Osm.), calculated osmolality (Calc. Osm.), serum sodium concentration (Serum Na+), urinary sodium concentration (Urinary Na+), and urine specific gravity (USG) in subgroup A2

Correlationrp
MAPEff. ECF Osm.0.500.021*
Calc. Osm.0.500.020*
Serum Na+0.490.021*
Urinary Na+−0.520.015*
USG−0.460.031*
MAP – mean arterial pressure, r – Spearman’s rank correlation coefficient, p – value of p, * – p < 0.05

In three dogs from subgroup A2, serum tonicity and calculated serum osmolality were below 275 mOsm/kg, and serum sodium concentration was below the reference interval; these dogs had high urine specific gravity and high urinary sodium concentration (Table 3). In these dogs, SIADH was diagnosed.

Table 3

Effective extracellular fluid osmolality, calculated serum osmolality serum and urinary sodium concentration, urine specific gravity, and mean arterial pressure in three non-azotaemic dogs (from subgroup A2) infected with B. canis and in which SIADH was diagnosed

Dog no.Eff. ECF Osm.

(mOsm/kg)
Calc. Osm.

(mOsm/kg)
Serum Na+

(mEq/L)
Urinary Na+

(mEq/L)
USGMAP (mmHg)
1255.5259.8124.8122.91.05293
2266.5272.0130.7136.01.06069
3249.8254.5122.4133.71.05585
Abbreviations as in Table 2

Discussion

This study is the first in which SIADH was recognised in canine babesiosis. Three dogs had hyponatraemia with serum tonicity and calculated serum osmolality lower than 275 mOsm/kg, high urinary sodium concentration, and high USG, which is strongly correlated with urine osmolality (3). These dogs had no clinical signs of hypovolaemia. An RFI lower than 2 and lack of azotaemia in these dogs indicated normal renal function. Before infection, these dogs were healthy and had no signs of hypothyroidism or hypocorticism. Changes of cortisol levels, ACTH, thyroid hormones, and TSH were observed in canine babesiosis, and therefore concentrations of these hormones were not determined in this study (27, 38). Before infection, the dogs had not been treated recently with any drugs (including diuretics). Thus, in the authors’ opinion these three dogs with hyponatraemia, hypotonicity, and hypoosmolality had SIADH. This result confirms observations from the previous studies on electrolyte disorders in canine babesiosis where hyponatraemia was observed in dogs infected with B. canis and B. rossi (1, 21, 39).

Fluid restriction is also useful in recognition of SIADH (11). However, the owners of these dogs did not heed this recommendation. The authors of this study did not determine urine osmolality. However, as mentioned above, Ayoub et al. (3) showed strong linear correlation between USG and urine osmolality in dogs with various pathological conditions. That study also showed no influence of bilirubinuria, haemoglobinuria, proteinuria, or, surprisingly, glucosuria on the correlation between USG and urine osmolality, and only a small influence of ketonuria on this relationship. According to Ayoub et al. (3), the influence of mild to moderate ketonuria on the correlation between USG and urine osmolality was not clinically relevant. Nevertheless, in this study no dogs had ketonuria. Thus, it seems highly probable that the high USG observed in the three dogs with SIADH reflected high urine osmolality.

In humans, there are three etiological classes of SIADH: endogenous, exogenous, and idiopathic. The exogenous class has aetiology in administration of vasopressin or its analogues, and the endogenous class includes four aetiologies: hypothalamic production of ADH, ectopic secretion of ADH (in neoplastic diseases), a potentiating ADH effect of some drugs, and nephrogenic syndrome of inappropriate antidiuresis (11). It seems probable that the cause of SIADH in canine babesiosis is increased hypothalamic production of vasopressin. This study showed correlations between MAP and serum tonicity, calculated serum osmolality, serum and urinary sodium concentrations, and USG, and it seems probable that increased production of vasopressin may be a response to hypotension which was observed in previous studies on canine babesiosis caused by infection with B. rossi and B. canis (18, 23, 36). However, in this study only one dog with diagnosed SIADH (dog no. 2) had hypotension (MAP < 80 mmHg).

According to Vantyghem et al. (31), stimulation of vasopressin production may also be potentiated by IL-6. Increased concentration of this pro-inflammatory cytokine was also observed in dogs infected with B. canis and B. rossi (12, 38). Thus it seems probable that IL-6 may contribute to the stimulation of vasopressin production and secretion in canine babesiosis. Moreover, stress, nausea, hypoglycaemia and hypoxia may be other possible causes of vasopressin secretion in infected dogs (31).

Hyponatraemia and SIADH in canine babesiosis seem contradictory to the hyperaldosteronism recognised in a previous study in dogs infected with B. canis (13). In the authors’ opinion it seems probable that increased aldosterone production is stimulated by hyponatraemia, and develops with a delay after SIADH. It was also speculated in the previous study that the delay in aldosterone production results from competition between stimulating factors for aldosterone like hyponatraemia and inhibiting factors like normovolaemia (30). Moreover, the previous study on hyperaldosteronism in canine babesiosis showed increased aldosterone production only in azotaemic dogs, and this study showed SIADH only in non-azotaemic dogs (13). Thus, in canine babesiosis SIADH is an early endocrine disorder (at the beginning of the disease), while hyperaldosteronism is a late endocrine disorder in affected animals.

One limitation of this study is the lack of an osmometer for determination of serum and urinary osmolality. However, serum osmolality and tonicity were calculated using results of serum sodium, glucose, and urea concentrations, and calculated serum osmolality should be very similar to the osmolality which would have been determined by osmometer. Moreover, as previously noted USG is strongly correlated with urine osmolality in dogs (3, 10). Another limitation of the study was the non-adherence by the owners of the dogs to the advice to restrict fluids, which could have led to correction of hyponatraemia (10). This was predicated on the mildness of the hyponatraemia set against their fear of azotaemia and renal complications.

In conclusion, there is a high probability that SIADH develops in non-azotaemic dogs with babesiosis. It is probably associated with lower blood pressure in infected dogs, and hypothalamic production of vasopressin is a possible response to hypotension in canine babesiosis. Thus, it seems that in fact it may be appropriate ADH secretion in dogs with parasites of the genus Babesia as a protective mechanism in hypotension which leads to hypoxia and renal failure in canine babesiosis. Hyperaldosteronism observed in azotaemic dogs with babesiosis would then seem to be the second line of defence in hypotensive dogs.

Conflict of InterestConflict of Interests Statement: The authors declare that there is no conflict of interests regarding the publication of this article.
Financial Disclosure Statement: The study was financed by the Faculty of Veterinary Medicine of Warsaw University of Life Sciences, and also partially by the owners of the dogs included in this research.
Animal Rights Statement: None required.

References

  • 1

    Adaszek Ł. Górna M. Winiarczyk S.: Electrolyte level and blood pH in dogs infected by various 18S RNA strains of Babaesia canis canis on the early stage of babesiosis. Berl Munch Tierarztl Wochenschr 2012 125 45–51.

    • PubMed
    • Export Citation
  • 2

    Adaszek Ł. Winiarczyk S.: Molecular characterization of Babesia canis canis isolates from naturally infected dogs in Poland. Vet Parasitol 2008 152 235–241.

    • Crossref
    • PubMed
    • Export Citation
  • 3

    Ayoub J.A. Beaufrère H. Acierno M.J.: Association between urine osmolality and specific gravity in dogs and the effect of commonly measured urine solutes on that association. Am J Vet Res 2013 74 1542–1545.

    • Crossref
    • PubMed
    • Export Citation
  • 4

    Baneth G. Florin-Christensen M. Cardoso L. Schnittger L.: Reclassification of Theileria annae as Babesia vulpes sp. nov. Parasit Vectors 2015 8 207. doi: 10.1186/s13071-015-0830-5.

    • Crossref
    • Export Citation
  • 5

    Barrot A.C. Bédard A. Dunn M.: Syndrome of inappropriate antidiuretic hormone secretion in a dog with a histiocytic sarcoma. Can Vet J 2017 58 713–715.

  • 6

    Bowles K.D. Brainard B.M. Coleman K.D.: Syndrome of inappropriate antidiuretic hormone in a bulldog with aspiration pneumonia. J Vet Intern Med 2015 29 972–976.

    • Crossref
    • Export Citation
  • 7

    Brofman P.J. Knostman K.A. DiBartola S.P.: Granulomatous amebic meningoencephalitis causing the syndrome of inappropriate secretion of antidiuretic hormone in a dog. J Vet Intern Med 2003 17 230–234.

    • Crossref
    • Export Citation
  • 8

    Clark I.A. Jacobson L.S.: Do babesiosis and malaria share a common disease process? Ann Trop Med Parasitol 1998 92 483–488.

  • 9

    Decaux G. Musch W.: Clinical laboratory evaluation of the syndrome of inappropriate secretion of antidiuretic hormone. Clin J Am Soc Nephrol 2008 3 1175–1184.

    • Crossref
    • PubMed
    • Export Citation
  • 10

    DiBartola S.P.: Disorders of sodium and water: hypernatremia and hyponatremia. In: Fluid Electrolyte and Acid–Base Disorders in Small Animal Practice edited by S.P. DiBartola W.B. Saunders Elsevier St. Louis 2006 pp. 47–79.

  • 11

    Esposito P. Piotti G. Bianzina S. Malul Y. Dal Canton A.: The syndrome of inappropriate antidiuresis: pathophysiology clinical management and new therapeutic options. Nephron Clin Pract 2011 119 c62–c73.

    • Crossref
    • PubMed
    • Export Citation
  • 12

    Goddard A. Leisewitz A.L. Kjelgaard-Hansen M. Kristensen A.T. Schoeman J.P.: Excessive pro-inflammatory serum cytokine concentrations in virulent canine babesiosis. PLoS One 2016 11 e0150113 doi: 10.1371/journal.pone.0150113.

    • Crossref
    • PubMed
    • Export Citation
  • 13

    Gójska-Zygner O. Zygner W.: Hyperaldosteronism and its association with hypotension and azotaemia in canine babesiosis. Vet Q 2015 35 37–42.

    • Crossref
    • PubMed
    • Export Citation
  • 14

    Hanson J. Hossain A. Charunwatthana P. Hassan M.U. Davis T.M. Lam S.W. Chubb S.A. Maude R.J. Yunus E.B. Haque G. White N.J. Day N.P. Dondorp A.M.: Hyponatremia in severe malaria: evidence for an appropriate anti-diuretic hormone response to hypovolemia. Am J Trop Med Hyg 2009 80 141–145.

    • Crossref
    • PubMed
    • Export Citation
  • 15

    Holst F.G. Hemmer C.J. Kern P. Dietrich M.: Inappropriate secretion of antidiuretic hormone and hyponatremia in severe falciparum malaria. Am J Trop Med Hyg 1994 50 602–607.

    • Crossref
    • PubMed
    • Export Citation
  • 16

    Hoorn E.J. van Wolfswinkel M.E. Hesselink D.A. de Rijke Y.B. Koelewijn R. van Hellemond J.J. van Genderen P.J.: Hyponatraemia in imported malaria: the pathophysiological role of vasopressin. Malaria J 2012 11 26 doi: 10.1186/14752875-11-26.

    • Crossref
    • Export Citation
  • 17

    Irwin P.J.: Canine babesiosis: from molecular taxonomy to control. Parasit Vectors 2009 2 S4 doi: 10.1186/1756-3305-2-S1-S4.

    • Crossref
    • PubMed
    • Export Citation
  • 18

    Jacobson L.S. Lobetti R.G. Vaughan-Scott T.: Blood pressure changes in dogs with babesiosis. J S Afr Vet Assoc 2000 71 14–20.

    • PubMed
    • Export Citation
  • 19

    Kang M.H. Park H.M.: Syndrome of inappropriate antidiuretic hormone secretion concurrent with liver disease in a dog. J Vet Med Sci 2012 74 645–649.

    • Crossref
    • Export Citation
  • 20

    Kjemtrup A.M. Wainwright K. Miller M. Penzhorn B.L. Carreno R.A.: Babesia conradae sp. Nov. a small canine Babesia identified in California. Vet Parasitol 2006 138 103–111.

  • 21

    Leisewitz A.L. Jacobson L.S. de Morais H.S. Reyers F.: The mixed acid-base disturbances of severe canine babesiosis. J Vet Intern Med 2001 15 445–452.

    • Crossref
    • PubMed
    • Export Citation
  • 22

    Martínez R. Torrente C.: Syndrome of inappropriate antidiuretic hormone secretion in a mini-breed puppy associated with aspiration pneumonia. Top Companion Anim Med 2017 32 146–150.

    • Crossref
    • Export Citation
  • 23

    Matijatko V. Kiš I. Torti M. Brkljačić M. Kučer N. Rafaj R.B. Grden D. Živičnjak T. Mrljak V.: Septic shock in canine babesiosis. Vet Parasitol 2009 162 263–270.

    • Crossref
    • PubMed
    • Export Citation
  • 24

    Milionis H.J. Liamis G.L. Elisaf M.S.: The hyponatremic patient: a systematic approach to laboratory diagnosis. CMAJ 2002 166 1056–1062.

    • PubMed
    • Export Citation
  • 25

    Rijnberk A. Biewenga W.J. Mol J.A.: Inappropriate vasopressin secretion in two dogs. Acta Endocrinol 1988 117 59–64.

    • Crossref
    • PubMed
    • Export Citation
  • 26

    Rymaszewska A. Adamska M.: Molecular evidence of vector-borne pathogens coinfecting dogs from Poland. Acta Vet Hung 2011 59 215–223.

    • Crossref
    • PubMed
    • Export Citation
  • 27

    Schoeman J.P. Rees P. Herrtage M.E.: Endocrine predictors of mortality in canine babesiosis caused by Babesia canis rossi Vet Parasitol 2007 148 75–82.

    • Crossref
    • PubMed
    • Export Citation
  • 28

    Schwartz W.B. Bennett W. Curelop S. Bartter F.C.: A Syndrome of Renal Sodium Loss and Hyponatremia Probably Resulting from Inappropriate Secretion of Antidiuretic Hormone. Am J Med 1957 23 529–542.

    • Crossref
    • PubMed
    • Export Citation
  • 29

    Shiel R.E. Pinilla M. Mooney C.T.: Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated With Congenital Hydrocephalus in a Dog. J Am Anim Hosp Assoc 2009 45 249–252.

    • Crossref
    • Export Citation
  • 30

    Song J. Hu X. Khan O. Tian Y. Verbalis J.G. Ecelbarger C.A.: Increased blood pressure aldosterone activity and regional differences in renal ENaC protein during vasopressin escape. Am J Physiol Renal Physiol 2004 287 1076–1083.

    • Crossref
    • Export Citation
  • 31

    Vantyghem M.C. Balavoine A.S. Wémeau J.L. Douillard C.: Hyponatremia and antidiuresis syndrome. Ann Endocrinol (Paris) 2011 72 500–512.

    • Crossref
    • PubMed
    • Export Citation
  • 32

    Waldrop J.E.: Urinary electrolytes solutes and osmolality. Vet Clin N Am Small Anim Pract 2008 38 503–512.

    • Crossref
    • Export Citation
  • 33

    Walls J.J. Caturegli P. Bakken J.S. Asanovich K.M. Dumler J.S.: Improved sensitivity of PCR for diagnosis of human granulocytic ehrlichiosis using epank1 genes of Ehrlichia phagocytophila-group ehrlichiae. J Clin Microbiol 2000 38 354–356.

    • PubMed
    • Export Citation
  • 34

    Welc-Falęciak R. Rodo A. Siński E. Bajer A.: Babesia canis and other tick-borne infections in dogs in Central Poland. Vet Parasitol 2009 166 191–198.

    • Crossref
    • PubMed
    • Export Citation
  • 35

    Wellman M.L. DiBartola S.P. Kohn C.W.: Applied physiology of body fluids in dogs and cats. In: Fluid Electrolyte and Acid–Base Disorders in Small Animal Practice edited by S.P. DiBartola W.B. Saunders Elsevier St. Louis 2006 pp. 3–26.

  • 36

    Zygner W. Gójska-Zygner O.: Association between decreased blood pressure and azotaemia in canine babesiosis. Pol J Vet Sci 2014 17 173–175.

    • Crossref
    • PubMed
    • Export Citation
  • 37

    Zygner W. Gójska-Zygner O. Bąska P. Długosz E.: Increased concentration of serum TNF alpha and its correlations with arterial blood pressure and indices of renal damage in dogs infected with Babesia canis Parasitol Res 2014 113 1499–1503.

    • Crossref
    • PubMed
    • Export Citation
  • 38

    Zygner W. Gójska-Zygner O. Bąska P. Długosz E.: Low T3 syndrome in canine babesiosis associated with increased serum IL-6 concentration and azotaemia. Vet Parasitol 2015 211 23–27.

    • Crossref
    • PubMed
    • Export Citation
  • 39

    Zygner W. Gójska-Zygner O. Wędrychowicz H.: Strong monovalent electrolyte imbalances in serum of dogs infected with Babesia canis Ticks Tick Borne Dis 2012 3 107–113.

    • Crossref
    • PubMed
    • Export Citation
  • 40

    Zygner W. Górski P. Wędrychowicz H.: Detection of the DNA of Borrelia afzelii Anaplasma phagocytophilum and Babesia canis in blood samples from dogs in Warsaw. Vet Rec 2009 164 465–467.

    • Crossref
    • PubMed
    • Export Citation

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  • 1

    Adaszek Ł. Górna M. Winiarczyk S.: Electrolyte level and blood pH in dogs infected by various 18S RNA strains of Babaesia canis canis on the early stage of babesiosis. Berl Munch Tierarztl Wochenschr 2012 125 45–51.

    • PubMed
    • Export Citation
  • 2

    Adaszek Ł. Winiarczyk S.: Molecular characterization of Babesia canis canis isolates from naturally infected dogs in Poland. Vet Parasitol 2008 152 235–241.

    • Crossref
    • PubMed
    • Export Citation
  • 3

    Ayoub J.A. Beaufrère H. Acierno M.J.: Association between urine osmolality and specific gravity in dogs and the effect of commonly measured urine solutes on that association. Am J Vet Res 2013 74 1542–1545.

    • Crossref
    • PubMed
    • Export Citation
  • 4

    Baneth G. Florin-Christensen M. Cardoso L. Schnittger L.: Reclassification of Theileria annae as Babesia vulpes sp. nov. Parasit Vectors 2015 8 207. doi: 10.1186/s13071-015-0830-5.

    • Crossref
    • Export Citation
  • 5

    Barrot A.C. Bédard A. Dunn M.: Syndrome of inappropriate antidiuretic hormone secretion in a dog with a histiocytic sarcoma. Can Vet J 2017 58 713–715.

  • 6

    Bowles K.D. Brainard B.M. Coleman K.D.: Syndrome of inappropriate antidiuretic hormone in a bulldog with aspiration pneumonia. J Vet Intern Med 2015 29 972–976.

    • Crossref
    • Export Citation
  • 7

    Brofman P.J. Knostman K.A. DiBartola S.P.: Granulomatous amebic meningoencephalitis causing the syndrome of inappropriate secretion of antidiuretic hormone in a dog. J Vet Intern Med 2003 17 230–234.

    • Crossref
    • Export Citation
  • 8

    Clark I.A. Jacobson L.S.: Do babesiosis and malaria share a common disease process? Ann Trop Med Parasitol 1998 92 483–488.

  • 9

    Decaux G. Musch W.: Clinical laboratory evaluation of the syndrome of inappropriate secretion of antidiuretic hormone. Clin J Am Soc Nephrol 2008 3 1175–1184.

    • Crossref
    • PubMed
    • Export Citation
  • 10

    DiBartola S.P.: Disorders of sodium and water: hypernatremia and hyponatremia. In: Fluid Electrolyte and Acid–Base Disorders in Small Animal Practice edited by S.P. DiBartola W.B. Saunders Elsevier St. Louis 2006 pp. 47–79.

  • 11

    Esposito P. Piotti G. Bianzina S. Malul Y. Dal Canton A.: The syndrome of inappropriate antidiuresis: pathophysiology clinical management and new therapeutic options. Nephron Clin Pract 2011 119 c62–c73.

    • Crossref
    • PubMed
    • Export Citation
  • 12

    Goddard A. Leisewitz A.L. Kjelgaard-Hansen M. Kristensen A.T. Schoeman J.P.: Excessive pro-inflammatory serum cytokine concentrations in virulent canine babesiosis. PLoS One 2016 11 e0150113 doi: 10.1371/journal.pone.0150113.

    • Crossref
    • PubMed
    • Export Citation
  • 13

    Gójska-Zygner O. Zygner W.: Hyperaldosteronism and its association with hypotension and azotaemia in canine babesiosis. Vet Q 2015 35 37–42.

    • Crossref
    • PubMed
    • Export Citation
  • 14

    Hanson J. Hossain A. Charunwatthana P. Hassan M.U. Davis T.M. Lam S.W. Chubb S.A. Maude R.J. Yunus E.B. Haque G. White N.J. Day N.P. Dondorp A.M.: Hyponatremia in severe malaria: evidence for an appropriate anti-diuretic hormone response to hypovolemia. Am J Trop Med Hyg 2009 80 141–145.

    • Crossref
    • PubMed
    • Export Citation
  • 15

    Holst F.G. Hemmer C.J. Kern P. Dietrich M.: Inappropriate secretion of antidiuretic hormone and hyponatremia in severe falciparum malaria. Am J Trop Med Hyg 1994 50 602–607.

    • Crossref
    • PubMed
    • Export Citation
  • 16

    Hoorn E.J. van Wolfswinkel M.E. Hesselink D.A. de Rijke Y.B. Koelewijn R. van Hellemond J.J. van Genderen P.J.: Hyponatraemia in imported malaria: the pathophysiological role of vasopressin. Malaria J 2012 11 26 doi: 10.1186/14752875-11-26.

    • Crossref
    • Export Citation
  • 17

    Irwin P.J.: Canine babesiosis: from molecular taxonomy to control. Parasit Vectors 2009 2 S4 doi: 10.1186/1756-3305-2-S1-S4.

    • Crossref
    • PubMed
    • Export Citation
  • 18

    Jacobson L.S. Lobetti R.G. Vaughan-Scott T.: Blood pressure changes in dogs with babesiosis. J S Afr Vet Assoc 2000 71 14–20.

    • PubMed
    • Export Citation
  • 19

    Kang M.H. Park H.M.: Syndrome of inappropriate antidiuretic hormone secretion concurrent with liver disease in a dog. J Vet Med Sci 2012 74 645–649.

    • Crossref
    • Export Citation
  • 20

    Kjemtrup A.M. Wainwright K. Miller M. Penzhorn B.L. Carreno R.A.: Babesia conradae sp. Nov. a small canine Babesia identified in California. Vet Parasitol 2006 138 103–111.

  • 21

    Leisewitz A.L. Jacobson L.S. de Morais H.S. Reyers F.: The mixed acid-base disturbances of severe canine babesiosis. J Vet Intern Med 2001 15 445–452.

    • Crossref
    • PubMed
    • Export Citation
  • 22

    Martínez R. Torrente C.: Syndrome of inappropriate antidiuretic hormone secretion in a mini-breed puppy associated with aspiration pneumonia. Top Companion Anim Med 2017 32 146–150.

    • Crossref
    • Export Citation
  • 23

    Matijatko V. Kiš I. Torti M. Brkljačić M. Kučer N. Rafaj R.B. Grden D. Živičnjak T. Mrljak V.: Septic shock in canine babesiosis. Vet Parasitol 2009 162 263–270.

    • Crossref
    • PubMed
    • Export Citation
  • 24

    Milionis H.J. Liamis G.L. Elisaf M.S.: The hyponatremic patient: a systematic approach to laboratory diagnosis. CMAJ 2002 166 1056–1062.

    • PubMed
    • Export Citation
  • 25

    Rijnberk A. Biewenga W.J. Mol J.A.: Inappropriate vasopressin secretion in two dogs. Acta Endocrinol 1988 117 59–64.

    • Crossref
    • PubMed
    • Export Citation
  • 26

    Rymaszewska A. Adamska M.: Molecular evidence of vector-borne pathogens coinfecting dogs from Poland. Acta Vet Hung 2011 59 215–223.

    • Crossref
    • PubMed
    • Export Citation
  • 27

    Schoeman J.P. Rees P. Herrtage M.E.: Endocrine predictors of mortality in canine babesiosis caused by Babesia canis rossi Vet Parasitol 2007 148 75–82.

    • Crossref
    • PubMed
    • Export Citation
  • 28

    Schwartz W.B. Bennett W. Curelop S. Bartter F.C.: A Syndrome of Renal Sodium Loss and Hyponatremia Probably Resulting from Inappropriate Secretion of Antidiuretic Hormone. Am J Med 1957 23 529–542.

    • Crossref
    • PubMed
    • Export Citation
  • 29

    Shiel R.E. Pinilla M. Mooney C.T.: Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated With Congenital Hydrocephalus in a Dog. J Am Anim Hosp Assoc 2009 45 249–252.

    • Crossref
    • Export Citation
  • 30

    Song J. Hu X. Khan O. Tian Y. Verbalis J.G. Ecelbarger C.A.: Increased blood pressure aldosterone activity and regional differences in renal ENaC protein during vasopressin escape. Am J Physiol Renal Physiol 2004 287 1076–1083.

    • Crossref
    • Export Citation
  • 31

    Vantyghem M.C. Balavoine A.S. Wémeau J.L. Douillard C.: Hyponatremia and antidiuresis syndrome. Ann Endocrinol (Paris) 2011 72 500–512.

    • Crossref
    • PubMed
    • Export Citation
  • 32

    Waldrop J.E.: Urinary electrolytes solutes and osmolality. Vet Clin N Am Small Anim Pract 2008 38 503–512.

    • Crossref
    • Export Citation
  • 33

    Walls J.J. Caturegli P. Bakken J.S. Asanovich K.M. Dumler J.S.: Improved sensitivity of PCR for diagnosis of human granulocytic ehrlichiosis using epank1 genes of Ehrlichia phagocytophila-group ehrlichiae. J Clin Microbiol 2000 38 354–356.

    • PubMed
    • Export Citation
  • 34

    Welc-Falęciak R. Rodo A. Siński E. Bajer A.: Babesia canis and other tick-borne infections in dogs in Central Poland. Vet Parasitol 2009 166 191–198.

    • Crossref
    • PubMed
    • Export Citation
  • 35

    Wellman M.L. DiBartola S.P. Kohn C.W.: Applied physiology of body fluids in dogs and cats. In: Fluid Electrolyte and Acid–Base Disorders in Small Animal Practice edited by S.P. DiBartola W.B. Saunders Elsevier St. Louis 2006 pp. 3–26.

  • 36

    Zygner W. Gójska-Zygner O.: Association between decreased blood pressure and azotaemia in canine babesiosis. Pol J Vet Sci 2014 17 173–175.

    • Crossref
    • PubMed
    • Export Citation
  • 37

    Zygner W. Gójska-Zygner O. Bąska P. Długosz E.: Increased concentration of serum TNF alpha and its correlations with arterial blood pressure and indices of renal damage in dogs infected with Babesia canis Parasitol Res 2014 113 1499–1503.

    • Crossref
    • PubMed
    • Export Citation
  • 38

    Zygner W. Gójska-Zygner O. Bąska P. Długosz E.: Low T3 syndrome in canine babesiosis associated with increased serum IL-6 concentration and azotaemia. Vet Parasitol 2015 211 23–27.

    • Crossref
    • PubMed
    • Export Citation
  • 39

    Zygner W. Gójska-Zygner O. Wędrychowicz H.: Strong monovalent electrolyte imbalances in serum of dogs infected with Babesia canis Ticks Tick Borne Dis 2012 3 107–113.

    • Crossref
    • PubMed
    • Export Citation
  • 40

    Zygner W. Górski P. Wędrychowicz H.: Detection of the DNA of Borrelia afzelii Anaplasma phagocytophilum and Babesia canis in blood samples from dogs in Warsaw. Vet Rec 2009 164 465–467.

    • Crossref
    • PubMed
    • Export Citation
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IMPACT FACTOR J Vet Res 2018: 0.829
5-year IMPACT FACTOR: 0.938

CiteScore 2018: 0.68

SCImago Journal Rank (SJR) 2018: 0.291
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