<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jvetres-2019-0045_s_005">
<h3>Introduction</h3>
<p>A previous study on canine babesiosis showed low serum tonicity in affected dogs, which may result from syndrome of inappropriate antidiuretic hormone secretion (SIADH). This endocrine disorder was recognised in human malaria which is considered a disease with similar pathogenesis to canine babesiosis. The aim of this study was to investigate the occurrence of SIADH in babesiosis-afflicted dogs.</p></sec>
<sec id="j_jvetres-2019-0045_s_006">
<h3>Material and Methods</h3>
<p>Serum and urinary sodium and urine specific gravity (USG) were determined in dogs with babesiosis. Mean arterial pressure (MAP) was measured at the beginning of the clinical examination. Serum tonicity and osmolality were calculated. Correlations were calculated between MAP and serum and urinary sodium concentrations, USG, serum tonicity, and calculated serum osmolality.</p></sec>
<sec id="j_jvetres-2019-0045_s_007">
<h3>Results</h3>
<p>Statistically significant correlations were observed between MAP and tonicity, calculated osmolality, USG, and serum and urinary sodium concentrations in non-azotaemic dogs. In three non-azotaemic dogs SIADH was recognised.</p></sec>
<sec id="j_jvetres-2019-0045_s_008">
<h3>Conclusion</h3>
<p>SIADH develops in non-azotaemic dogs with babesiosis. It is probably associated with decreased blood pressure in infected dogs. Thus, it seems that in fact it may be appropriate vasopressin secretion in canine babesiosis as a protective mechanism in hypotension which leads to hypoxia and renal failure in affected dogs.</p></sec>

</abstract>

Introduction
A previous study on canine babesiosis showed low serum tonicity in affected dogs, which may result from syndrome of inappropriate antidiuretic hormone secretion (SIADH). This endocrine disorder was recognised in human malaria which is considered a disease with similar pathogenesis to canine babesiosis. The aim of this study was to investigate the occurrence of SIADH in babesiosis-afflicted dogs.

Material and Methods
Serum and urinary sodium and urine specific gravity (USG) were determined in dogs with babesiosis. Mean arterial pressure (MAP) was measured at the beginning of the clinical examination. Serum tonicity and osmolality were calculated. Correlations were calculated between MAP and serum and urinary sodium concentrations, USG, serum tonicity, and calculated serum osmolality.

Results
Statistically significant correlations were observed between MAP and tonicity, calculated osmolality, USG, and serum and urinary sodium concentrations in non-azotaemic dogs. In three non-azotaemic dogs SIADH was recognised.

Conclusion
SIADH develops in non-azotaemic dogs with babesiosis. It is probably associated with decreased blood pressure in infected dogs. Thus, it seems that in fact it may be appropriate vasopressin secretion in canine babesiosis as a protective mechanism in hypotension which leads to hypoxia and renal failure in affected dogs.

Hyponatraemia and syndrome of inappropriate antidiuretic hormone secretion in non-azotaemic dogs with babesiosis associated with decreased arterial blood pressure

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction
A previous study on canine babesiosis showed low serum tonicity in affected dogs, which may result from syndrome of inappropriate antidiuretic...

Parameter	Group	W	p
Effective ECF osmolality	A	0.968	0.532
	B	0.964	0.769
	A1	0.971	0.910
	A2	0.957	0.469
Calculated osmolality	A	0.954	0.243
	B	0.984	0.989
	A1	0.891	0.239
	A2	0.944	0.263
Serum Na⁺	A	0.966	0.465
	B	0.959	0.690
	A1	0.947	0.681
	A2	0.958	0.486
Urinary Na⁺	A	0.952	0.214
	B	0.988	0.998
	A1	0.962	0.825
	A2	0.953	0.363
USG	A	0.919	0.029*
	B	0.934	0.309
	A1	0.853	0.104
	A2	0.902	0.039*
MAP	A	0.849	0.001*
	B	0.976	0.939
	A1	0.892	0.245
	A2	0.856	0.005*

Dog no.	Eff. ECF Osm. (mOsm/kg)	Calc. Osm. (mOsm/kg)	Serum Na⁺ (mEq/L)	Urinary Na⁺ (mEq/L)	USG	MAP (mmHg)
1	255.5	259.8	124.8	122.9	1.052	93
2	266.5	272.0	130.7	136.0	1.060	69
3	249.8	254.5	122.4	133.7	1.055	85

Correlation		r	p
MAP	Eff. ECF Osm.	0.50	0.021*
	Calc. Osm.	0.50	0.020*
	Serum Na⁺	0.49	0.021*
	Urinary Na⁺	−0.52	0.015*
	USG	−0.46	0.031*

Hyponatraemia and syndrome of inappropriate antidiuretic hormone secretion in non-azotaemic dogs with babesiosis associated with decreased arterial blood pressure

Published Online: Sep 13, 2019

Page range: 339 - 344

Received: Feb 01, 2019

Accepted: Jul 02, 2019

DOI: https://doi.org/10.2478/jvetres-2019-0045

Keywords
dog, canine babesiosis, hyponatraemia, hypotension, SIADH

© 2019 O. Gójska-Zygner et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Results of the Shapiro–Wilk W-test for normality in groups A and B and subgroups A1 and A2 in the distribution of effective ECF osmolality, calculated osmolality, serum sodium concentration, urinary sodium concentration, urine specific gravity, and mean arterial pressure

Effective extracellular fluid osmolality, calculated serum osmolality serum and urinary sodium concentration, urine specific gravity, and mean arterial pressure in three non-azotaemic dogs (from subgroup A2) infected with B. canis and in which SIADH was diagnosed

Statistically significant correlations between mean arterial pressure and effective ECF osmolality (Eff. ECF Osm.), calculated osmolality (Calc. Osm.), serum sodium concentration (Serum Na+), urinary sodium concentration (Urinary Na+), and urine specific gravity (USG) in subgroup A2

Hyponatraemia and syndrome of inappropriate antidiuretic hormone secretion in non-azotaemic dogs with babesiosis associated with decreased arterial blood pressure

Published Online: Sep 13, 2019

Page range: 339 - 344

Received: Feb 01, 2019

Accepted: Jul 02, 2019

DOI: https://doi.org/10.2478/jvetres-2019-0045

Keywordsdog, canine babesiosis, hyponatraemia, hypotension, SIADH

© 2019 O. Gójska-Zygner et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Results of the Shapiro–Wilk W-test for normality in groups A and B and subgroups A1 and A2 in the distribution of effective ECF osmolality, calculated osmolality, serum sodium concentration, urinary sodium concentration, urine specific gravity, and mean arterial pressure

Effective extracellular fluid osmolality, calculated serum osmolality serum and urinary sodium concentration, urine specific gravity, and mean arterial pressure in three non-azotaemic dogs (from subgroup A2) infected with B. canis and in which SIADH was diagnosed

Statistically significant correlations between mean arterial pressure and effective ECF osmolality (Eff. ECF Osm.), calculated osmolality (Calc. Osm.), serum sodium concentration (Serum Na+), urinary sodium concentration (Urinary Na+), and urine specific gravity (USG) in subgroup A2

Keywords
dog, canine babesiosis, hyponatraemia, hypotension, SIADH