Molluscicidal Activities of Curcumin-Nisin Polylactic Acid Nanoparticle (PLA) on Adult Snail Intermediate Hosts of Schistosomes and Fasciola spp.

Abstract

Digenetic trematode infections including schistosomiasis and fascioliasis have highly neglected statuses but are a menace to people in the poorest countries of the tropics, causing high morbidity and mortality in humans as well as great global losses in livestock production. This has neccesitated the widespread search for better control options for the snail vectors of these diseases. Hence, a novel drug - curcumin and nisin poly lactic acid (PLA) entrapped nanoparticles (CurNisNp) was screened for molluscicidal activity against the adults (> 2 months old) of Biomphalaria pfeifferi, Bulinus globosus and Lymnaea natalensis vector snails. Mortality was determined after 96-h of exposure at varying concentrations. The snails of the species L. natalensis were found to be the most susceptible to the molluscicide (LC50 323.6 ppm). This finding further supports the desirability of curcumin-nisin polylactic acid (PLA) nanoparticles as a molluscicide and therefore shows that it could be a good alternative to conventional molluscicides with prospects in the selective control of fascioliasis. However, more optimization of the drug could ensure a greater molluscicidal potency.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Frezza, T.F., Gremião, M.P.D., Zanotti-Magalhães, E.M., Magalhãe s, L.A., de Souza,A.L.R. & Allegretti, S.M. (2013). Liposomal-praziquantel: efficacy against Schistosoma mansoni in a preclinical assay, Acta Tropica, 128, 70–75. https://doi.org/10.1016/j.actatropica.2013.06.011

  • 2 Souza, A.L.R., Andreani, T., De Oliveira, R.N., Kiill, C.P., Dos Santos, F.K., Allegretti, S.M., Chaud, M.V., Souto, E.B., Silva, A.M. & Gremião, M.P.D. (2014). In vitro evaluation of permeation, toxicity and effect of praziquantel-loaded solid lipidnanoparticles against Schistosoma mansoni as a strategy to improve efficacy ofthe schistosomiasis treatment. International Journal of Pharmaceutics, 46, 31–37. https://doi.org/10.1016/j.ijpharm.2013.12.022

  • 3 Dauda, K., Busari, Z., Morenikeji, O., Afolayan, F., Oyeyemi, Y., Meena, J., Sahu, D. & Panda, A. (2017) Poly-D,L-lactic-co-glycolic acid-based artesunate nanoparticles,formulation, antimalarial and toxicity assessments. Journal of Zheijang University SCIENCE B - Biomedicine & Biotechnology, 18, 977-985. https://doi.org/10.1631/jzus.B1600389

  • 4 Jeon, W., Lee, S., DH, M. & Ban, C. (2013). Colorimetric aptasensor for the diagnosis of malaria based on cationic polymers and gold nanoparticles. Analytical Biochemistry, 439, 11–16. https://doi.org/10.1016/j.ab.2013.03.032

  • 5 Alnasser, Y., Ferradas, C., Clark, T., Calderon, M., Gurbillon, A., Gamboa, D., McKakpo, U.S., Quakyi, I. A., Bosompem, K. M., Sullivan, D. J. (2016). Colorimetric detection of Plasmodium vivax in urine using MSP10 oligonucleotides and gold nanoparticles. PLoS Neglected Tropical Disease, 10, 1-12. https://doi.org/10.1371/journal.pntd.0005029

  • 6 Kame, M.M., Elbaz, H.G., Demerdash, Z.A., Elmoneem, E.M.A., Hendawy, M.A. & Bayoumi, I.R. (2016). Nano-immunoassay for diagnosis of active schistosomal infection. World Journal of Medical Science, 13, 27. https://doi.org/10.5829/idosi.wjms.2016.13.1.96189

  • 7 Bakshi, R.P., Tatham, L.M., Savage, A., Tripathi, A.K., Mlambo, G., Ippolito, M.M., Nenortas, E., Rannard, S.P., Owen, A. & Shapiro, T.A. (2018). Long-acting injectable atovaquone nanomedicines for malaria prophylaxis. Nature Communication, 9, Article number: 315. https://doi.org/10.1038/s41467-017-02603-z

  • 8 Fuaad, A.A.H.A., Roubille, R., Pearson, M.S., Pickering, D.A., Loukas, A.C., Skwarczynski, M. & Toth, I. (2015). The use of a conformational cathepsinD-derived epitope for vaccine development against Schistosoma mansoni. Bioorganic Medicinal Chemistry, 23, 1307–1312.

  • 9 Guang, X.Y., Wang, J.J., He, Z.G., Chen, G.X., Din, G.L., Dai, J.J. & Yang, X.H. (2013). Molluscicidal effects of nano-silver biological molluscicide and niclosamide. Chinese Journal of Schistosomiasis Control, 25, 503–505.

  • 10 Omobhude M.E., Morenikeji O.A. & Oyeyemi O.T. (2017). Molluscicidal activities of curcumin-nisin polylactic acid nanoparticle on Biomphalaria pfeifferi. PLoS Neglected Tropical Disease, 11, e0005855. https://dx.doi.org/10.1371%2Fjournal.pntd.0005855

  • 11 World Health Organisation. Schistosomiasis Factsheet. (available 20 February, 2018), [assessed 23 August, 2018], http://www.who.int/news-room/factsheet/detail/schistosomiasis.

  • 12 Rahman, A.K.M.A., Islam, S.K.S., Talukder, H., Hassan, K., Dhand, N.K. & Ward, M.P. (2010). Fascioliasis risk factors and space-time clusters in domestic ruminants in Bangladesh. Parasites & Vectors, 10, 228. https://doi.org/10.1186/s13071-017-2168-7

  • 13 Otubanjo, O. (2013). Parasites of man and animals. Lagos: Concept Publications.

  • 14 Asemota, A., Hassan, A. & Idu, M. (2015). Preliminary Screening of some Nigerian medicinal plants for molluscicidal activities. International Journal of Analytical, Pharmaceutical and Biochemical Sciences, 4, 24-33.

  • 15 Ali, S.M., Yousef, N.M.H. & Nafady, N.A. (2015). Application of biosynthesized silver nanoparticles for the control of land snail Eobania vermiculata and some plant pathogenic fungi. Journal of Nanomaterials, Article ID 218904, 10 pages. http://dx.doi.org/10.1155/2015/218904

  • 16 Salawu, O.T.& Odaibo, A.B. (2011). The molliscicidal effects of Hyptis suaveolens on different stages of Bulinus globosus in the laboratory. African Journal of Biotechnology, 10, 10241-10247. https://doi.org/10.5897/AJB10.415

  • 17 World Health Organisation (1983). Report of the scientific working group on plant molluscicides. UNDP/World Bank/WHO special programme for Research and Training in Tropical Diseases. World Health Organization, Geneva.

  • 18 Otarigho, B. & Morenikeji, O.A. (2012). Molluscicidal effects of aqueous and ethanolic extracts of lemongrass (Cymbopogon citratus) leaf against the different developmental stages of Biomphalaria pfeifferi. New York Science Journal, 5, 70-77.

  • 19 Webbe, G. (1961). Laboratory and field trials of a new molluscicide, Bayer 73, in Tangayika. Bulletin of the World Health Organization, 25, 525-531.

  • 20 Silva, L., Souza, B., de Almeida Bessa, E.C. & Pinheiro, J. (2012). Effect of successive applications of the sub-lethal concentration of Solanum paniculatum in Subulina octona (Subulinidae). Journal of Natural Products, 5, 157-167.

  • 21 Adetunji, V.O. & Salawu, O.T. (2010). Efficacy of ethanolic leaf extracts of Carica papaya and Terminalia catappa as molluscicides against the snail intermediate hosts of schistosomiasis. Journal of Medicinal Plant Research, 4, 2348-2352. https://doi.org/10.5897/JMPR10.468

  • 22 Hatil, H.E., Rehab Omer, E.N. & Sami, A.K. (2010). Molluscicidal Activity of the Essential oils of Cymbopogon nervatus leaves and Boswellia papyrifera resins. Curr. Res. Journal of Biological Sciences, 2, 139-142.

  • 23 Molla, E., Giday, M. & Erko, B. (2013). Laboratory assessment of the molluscicidal and cercariacidal activities of Balanites aegyptiaca. Asian Pacific Journal of Tropical Biomedicine, 3, 657-662. https://dx.doi.org/10.1016%2FS2221-1691(13)60132-X

  • 24 Okeke, O.C. & Ubachukwu, P.O. (2011). Molluscicidal Effects of Talinum triangulare on Bulinus truncatus. Nigerian Journal of Biotechnology, 22, 13-16.

  • 25 Carvalho, D.D., Takeuchi1, K.P., Geraldine, R.M., de Moura, C.J. & Torres, M.L. (2015). Production, solubility and antioxidant activity of curcumin nanosuspension. Food Sci. Technol. Campinas, 35, 115-119. http://dx.doi.org/10.1590/1678-457X.6515.

OPEN ACCESS

Journal + Issues

Search