<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Digenetic trematode infections including schistosomiasis and fascioliasis have highly neglected statuses but are a menace to people in the poorest countries of the tropics, causing high morbidity and mortality in humans as well as great global losses in livestock production. This has neccesitated the widespread search for better control options for the snail vectors of these diseases. Hence, a novel drug - curcumin and nisin poly lactic acid (PLA) entrapped nanoparticles (CurNisNp) was screened for molluscicidal activity against the adults (> 2 months old) of <italic>Biomphalaria pfeifferi, Bulinus globosus</italic> and <italic>Lymnaea natalensis</italic> vector snails. Mortality was determined after 96-h of exposure at varying concentrations. The snails of the species <italic>L. natalensis</italic> were found to be the most susceptible to the molluscicide (LC<sub>50</sub> 323.6 ppm). This finding further supports the desirability of curcumin-nisin polylactic acid (PLA) nanoparticles as a molluscicide and therefore shows that it could be a good alternative to conventional molluscicides with prospects in the selective control of fascioliasis. However, more optimization of the drug could ensure a greater molluscicidal potency.</p>
</abstract>

Digenetic trematode infections including schistosomiasis and fascioliasis have highly neglected statuses but are a menace to people in the poorest countries of the tropics, causing high morbidity and mortality in humans as well as great global losses in livestock production. This has neccesitated the widespread search for better control options for the snail vectors of these diseases. Hence, a novel drug - curcumin and nisin poly lactic acid (PLA) entrapped nanoparticles (CurNisNp) was screened for molluscicidal activity against the adults (> 2 months old) of Biomphalaria pfeifferi, Bulinus globosus and Lymnaea natalensis vector snails. Mortality was determined after 96-h of exposure at varying concentrations. The snails of the species L. natalensis were found to be the most susceptible to the molluscicide (LC50 323.6 ppm). This finding further supports the desirability of curcumin-nisin polylactic acid (PLA) nanoparticles as a molluscicide and therefore shows that it could be a good alternative to conventional molluscicides with prospects in the selective control of fascioliasis. However, more optimization of the drug could ensure a greater molluscicidal potency.

Molluscicidal Activities of Curcumin-Nisin Polylactic Acid Nanoparticle (PLA) on Adult Snail Intermediate Hosts of <italic>Schistosomes</italic> and <italic>Fasciola</italic> spp.

Parasitology Research Unit, Department of Zoology

Advanced Research in Life Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Molluscicidal Activities of Curcumin-Nisin Polylactic Acid Nanoparticle (PLA) on Adult Snail Intermediate Hosts of  and  spp.

Digenetic trematode infections including schistosomiasis and fascioliasis have highly neglected statuses but are a menace to people in the poorest countries of...

Molluscicidal Activities of Curcumin-Nisin Polylactic Acid Nanoparticle (PLA) on Adult Snail Intermediate Hosts of Schistosomes and Fasciola spp.

Published Online: Jun 10, 2019

Page range: 28 - 32

Accepted: May 01, 2019

DOI: https://doi.org/10.2478/arls-2019-0007

Keywords
Curcumin, nisin, nanoparticles, schistosomiasis, fascioliasis, snail intermediate host, molluscicidal activity

© 2019 Michael E. Omobhude et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Molluscicidal Activities of Curcumin-Nisin Polylactic Acid Nanoparticle (PLA) on Adult Snail Intermediate Hosts of Schistosomes and Fasciola spp.

Published Online: Jun 10, 2019

Page range: 28 - 32

Accepted: May 01, 2019

DOI: https://doi.org/10.2478/arls-2019-0007

KeywordsCurcumin, nisin, nanoparticles, schistosomiasis, fascioliasis, snail intermediate host, molluscicidal activity

© 2019 Michael E. Omobhude et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Curcumin, nisin, nanoparticles, schistosomiasis, fascioliasis, snail intermediate host, molluscicidal activity