Glutathione Conjugates of Ochratoxin a as Biomarkers of Exposure / Glutationski Konjugati Okratoksina A Kao Biomarkeri Izloženosti

1. Van der Merwe KJ, Steyn PS, Fourie L, Scott DB, Theron, JJ. Ochratoxin A, a toxic metabolite produced by Aspergillusochraceus Wilh. Nature 1965;205:1112-3.10.1038/2051112a0Search in Google Scholar

2. Pohland AE, Nesheim S, Friedman L. Ochratoxin A, a review. Pure Appl Chem 1992;64:1029-46.10.1351/pac199264071029Search in Google Scholar

3. Pfohl-Leszkowicz A, Manderville RA. Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans. Mol Nutr Food Res 2007;51:61-99.10.1002/mnfr.200600137Search in Google Scholar

4. Mally A, Dekant W. Mycotoxins and the kidney: modes of action for renal tumor formation by ochratoxin A in rodents. Mol Nutr Food Res 2009;53:467-78.10.1002/mnfr.200800149Search in Google Scholar

5. Kuiper-Goodman T, Hilts C, Billiard SM, Kiparissis Y, Richard IDK, Hayward S. Health risk assessment of ochratoxin A for all age-sex strata in a market economy. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2010;27:212-40.10.1080/02652030903013278Search in Google Scholar

6. International Agency for Research on Cancer (IARC). Ochratoxin A. In: Monographs on the evaluation of carcinogenic risks to humans. No. 56. Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. Lyon; IARC; 1993. p. 489-521.Search in Google Scholar

7. Boorman G, editor. National Toxicology Program. Technical Report on the Toxicology and Carcinogenesis Studies of Ochratoxin A (CAS No 303-47-9) in F344/N Rats (Gavage Studies). Natl Toxicol Program Tech Rep Ser 1989;358:1-142.Search in Google Scholar

8. Stoev SD. Studies on carcinogenic and toxic effects of ochratoxin A in chicks. Toxins 2010;2:649-64.10.3390/toxins2040649Search in Google Scholar

9. Krogh P, Hald B, Pleština R, Ceović S. Balkan (endemic) nephropathy and foodborne ochratoxin A: preliminary results of a survey of foodstuffs. Acta Pathol Microbiol Scand B 1977;85:238-40.Search in Google Scholar

10. Grosso F, Said S, Mabrouk I, Fremy JM, Castegnaro M, Jemmali M, Dragacci S. New data on the occurrence of ochratoxin A in human sera from patients affected or not by renal diseases in Tunisia. Food Chem Toxicol 2003;41:1133-40.10.1016/S0278-6915(03)00067-XSearch in Google Scholar

11. WHO Food Additives Series 47. Safety evaluation of certain mycotoxins in food [displayed 19 September 2012]. Available at http://www.inchem.org/documents/jecfa/jecmono/v47je01. htmSearch in Google Scholar

12. Hibi D, Suzuki Y, Ishii Y, Jin M, Watanabe M, Sugita-Konishi Y, Yanai T, Nohmi T, Nishikawa A, Umemura T. Site-specific in vivo mutagenicity in the kidney of gpt delta rats given a carcinogenic dose of ochratoxin A. Toxicol Sci 2011;122:406-14.10.1093/toxsci/kfr13921622941Search in Google Scholar

13. Manderville RA. A case for the genotoxicity of ochratoxin A by bioactivation and covalent DNA adduction. Chem Res Toxicol 2005;18:1091-7.10.1021/tx050070p16022501Search in Google Scholar

14. Pfohl-Leszkowicz A, Manderville RA. An update on direct genotoxicity as a molecular mechanism of ochratoxin A carcinogenicity. Chem Res Toxicol 2012;25:252-62.10.1021/tx200430f22054007Search in Google Scholar

15. Waidyanatha S, Lin PH, Rappaport SM. Characterization of chlorinated adducts of hemoglobin and albumin following administration of pentachlorophenol to rats. Chem Res Toxicol 1996;9:647-53.10.1021/tx950172nSearch in Google Scholar

16. Gillman IG, Clark TN, Manderville RA. Oxidation of ochratoxin A by an Fe-porphyrin system: model for enzymatic activation and DNA cleavage. Chem Res Toxicol 1999;12:1066-76.10.1021/tx9901074Search in Google Scholar

17. Mally A, Zepnik H, Wanek P, Eder E, Dingley K, Ihmels H, Volkel W, Dekant W. Ochratoxin A: lack of formation of covalent DNA adducts. Chem Res Toxicol 2004;17:234-42.10.1021/tx034188mSearch in Google Scholar

18. Manderville RA, Pfohl-Leszkowicz A. Bioactivation and DNA adduction as a rationale for ochratoxin A carcinogenesis. World Mycotoxin J 2008;1:357-67.10.3920/WMJ2008.x039Search in Google Scholar

19. Pfohl-Leszkowicz A. Ochratoxin A and aristolochic acid involvement in nephropathies and associated urothelial tract tumours. Arh Hig Rada Toksikol 2009;60:465-83.10.2478/10004-1254-60-2009-2000Search in Google Scholar

20. Tozlovanu M, Faucet-Marquis V, Pfohl-Leszkowicz A, Manderville RA. Genotoxicity of the hydroquinone metabolite of ochratoxin A: structure-activity relationships for covalent DNA adduction. Chem Res Toxicol 2006;19:1241-7.10.1021/tx060138gSearch in Google Scholar

21. Dai J, Wright MW, Manderville RA. Ochratoxin A forms a carbon-bonded C8-deoxyguanosine nucleoside adduct: implications for C8 reactivity by a phenolic radical. J Am Chem Soc 2003;125:3716-7.10.1021/ja034221rSearch in Google Scholar

22. Mantle PG, Faucet-Marquis V, Manderville RA, Squillaci B, Pfohl-Leszkowicz A. Structures of covalent adducts between DNA and ochratoxin A: a new factor in debate about genotoxicity and human risk assessment. Chem Res Toxicol 2010;23:89-98.10.1021/tx900295aSearch in Google Scholar

23. Hadjeba-Medjdoub K, Tozlovanu M, Pfohl-Leszkowicz A, Frenette C, Paugh RJ, Manderville RA. Structure-activity relationships imply different mechanisms of action for ochratoxin A-mediated cytotoxicity and genotoxicity. Chem Res Toxicol 2012;25:181-90.10.1021/tx200406cSearch in Google Scholar

24. Doster RC, Sinnhuber RO. Comparative rates of hydrolysis of ochratoxins A and B in vitro. Food Cosmet Toxicol 1972;10:389-94.10.1016/S0015-6264(72)80257-8Search in Google Scholar

25. Stander MA, Steyn PS, van der Westhuizen FH, Payne BE. A kinetic study into the hydrolysis of the ochratoxins and analogues by carboxypeptidase A. Chem Res Toxicol 2001;14:302-4.10.1021/tx000221iSearch in Google Scholar

26. Mally A, Keim-Heusler H, Amberg A, Kurz M, Zepnik H, Mantle P, Volkel W, Hard GC, Dekant W. Biotransformation and nephrotoxicity of ochratoxin B in rats. Toxicol Appl Pharmacol 2005;206:43-53.10.1016/j.taap.2004.11.007Search in Google Scholar

27. Castegnaro M, Canadas, D, Vrabcheva T, Petkova-Bocharova T, Chernozemsky IN, Pfohl-Leszkowicz A. Balkan endemic nephropathy: role of ochratoxins A through biomarkers. Mol Nutr Food Res 2006;50:519-29.10.1002/mnfr.200500182Search in Google Scholar

28. Duarte SC, Pena A, Lino CM. Human ochratoxin A biomarkers-from exposure to effect. Crit Rev Toxicol 2011;41:187-212.10.3109/10408444.2010.529103Search in Google Scholar

29. Molinie A, Faucet V, Castegnaro M, Pfohl-Leszkowicz A. Analysis of some breakfast cereals on the French market for their contents of ochratoxin A, citrinin and fumonisin B1: development of a method for simultaneous extraction of ochratoxin A and citrinin. Food Chem 2005;92:391-400.10.1016/j.foodchem.2004.06.035Search in Google Scholar

30. Dai J, Park G, Wright MW, Adams M, Akman SA, Manderville RA. Detection and characterization of a glutathione conjugate of ochratoxin A. Chem Res Toxicol 2002;15:1581-8.10.1021/tx0255929Search in Google Scholar

31. Brow ME, Dai J, Park G, Wright MW, Gillman IG, Manderville RA. Photochemically catalyzed reaction of ochratoxin A with D- and L-cysteine. Photochem Photobiol 2002;76:649-56.10.1562/0031-8655(2002)076<0649:PCROOA>2.0.CO;2Search in Google Scholar

32. Il’ichev YV, Perry JL, Manderville RA, Chignell CF, Simon JD. The pH-dependent primary photoreactions of ochratoxin A. J Phys Chem B 2001;105:11369-76.10.1021/jp012683qSearch in Google Scholar

33. Pfohl-Leszkowicz A, Tozlovanu M, Manderville R, Peraica M, Castegnaro M, Stefanovic V. New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in Human Nephropathy and Urinary tract tumor. Mol Nutr Food Res 2007;51:1131-46.10.1002/mnfr.200700045Search in Google Scholar

34. Jennings-G JE, Tozlovanu M, Manderville R, Miller MS, Pfohl-Leszkowicz A, Schwartz GG. Ochratoxin A: In utero exposure in mice induces adducts in testicular DNA. Toxins 2010;2:1428-44.10.3390/toxins2061428Search in Google Scholar

35. Faucet-Marquis V, Pont F, Stormer F, Rizk T, Castegnaro M, Pfohl-Leszkowicz A. Evidence of a new dechlorinated OTA derivative formed in opossum kidney cell cultures after pretreatment by modulators of glutathione pathways. Correlation with DNA adducts formation. Mol Nutr Food Res 2006;50:531-42.Search in Google Scholar

36. Dais P, Stefanaki I, Fragaki G, Mikros E. Conformational analysis of ochratoxin A by NMR spectroscopy and computational molecular modeling. J Phys Chem B 2005;109:16926-36.10.1021/jp058035eSearch in Google Scholar

37. Pfohl-Leszkowicz A, Castegnaro M. Further arguments in favour of direct covalent binding of ochratoxin A (OTA) after metabolic biotransformation. Food Addit Contam 2005;22(Suppl 1):75-87.10.1080/02652030500309400Search in Google Scholar

38. Castegnaro M, Mohr U, Pfohl-Leszkowicz A, Esteve J, Steinmann J, Tillman J, Michelon J, Bartsch H. Sex and strain-specific induction of renal tumours by ochratoxin A rats correlates with DNA adduction. Int J Cancer 1998;77:70-5.10.1002/(SICI)1097-0215(19980703)77:1<70::AID-IJC12>3.0.CO;2-DSearch in Google Scholar

39. Pfohl-Leszkowicz A, Pinelli E, Bartsch H, Mohr U, Castegnaro M. Sex and strain differences in ochratoxin A metabolism and DNA adduction in two strains of rats. Mol Carcinogen 1998;23:76-83.10.1002/(SICI)1098-2744(199810)23:2<76::AID-MC4>3.0.CO;2-BSearch in Google Scholar

40. Pfohl-Leszkowicz A, Bartsch H, Azemar B, Mohr U, Esteve J, Castegnaro M. MESNA protects rats against nephrotoxicity but not carcinogenicity induced by ochratoxin A, implicating two separate pathways. Facta Universitatis Ser Med Biol 2002;9:57-63.Search in Google Scholar

41. Vettorazzi A, de Troconiz IF, Gonzalez-Penas E, Arbillaga L, Corcuera L-A, Gil AG, de Cerain, AL. Kidney and liver distribution of ochratoxin A in male and female F344 rats. Food Chem Toxicol 2011;49:1935-42.10.1016/j.fct.2011.04.021Search in Google Scholar

42. Petkova-Bocharova T, El Adlouni C, Faucet V, Pfohl- Leszkowicz A, Mantle P. Analysis for DNA adducts, ochratoxin A content and enzymes expression in kidneys of pigs exposed to mild experimental chronic ochratoxicosis. Facta Universitatis Ser Med Biol 2003;10:111-5. Search in Google Scholar