Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain

Open access

Abstract

A novel mucoadhesive buccal tablet containing flurbiprofen (FLB) and lidocaine HCl (LID) was prepared to relieve dental pain. Tablet formulations (F1-F9) were prepared using variable quantities of mucoadhesive agents, hydroxypropyl methyl cellulose (HPMC) and sodium alginate (SA). The formulations were evaluated for their physicochemical properties, mucoadhesive strength and mucoadhesion time, swellability index and in vitro release of active agents. Release of both drugs depended on the relative ratio of HPMC:SA. However, mucoadhesive strength and mucoadhesion time were better in formulations, containing higher proportions of HPMC compared to SA. An artificial neural network (ANN) approach was applied to optimise formulations based on known effective parameters (i.e., mucoadhesive strength, mucoadhesion time and drug release), which proved valuable. This study indicates that an effective buccal tablet formulation of flurbiprofen and lidocaine can be prepared via an optimized ANN approach.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. N. Salamat-Miller M. Chittchang and T. P. Johnston The use of mucoadhesive polymers in buccal drug delivery Adv. Drug Deliv. Rev. 57 (2005) 1666–1691; DOI: 10.1016/j.addr.2005.07.003.

  • 2. R. A. Medve J. Wang and R. Karim Tramadol and acetaminophen tablets for dental pain Anesth. Prog. 48 (2001) 79–81.

  • 3. B. W. Morrison S. Christensen W. Yuan J. Brown S. Amlani and B. Seidenberg Analgesic efficacy of the cyclooxygenase-2-specific inhibitor rofecoxib in post-dental surgery pain: a randomized controlled trial Clin. Ther. 21 (1999) 943–953; DOI: 10.1016/S0149-2918(99)80016-2.

  • 4. J. M. Swegle and C. Logemann Management of common opioid-induced adverse effects Am. Fam. Physician 74 (2006) 1347–1354.

  • 5. I. Bjarnason J. Hayllar A. J. Macpherson and A. Russell Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans Gastroenterology 104 (1993) 1832–1847.

  • 6. A. Sultan H. J. McQuay R. A. Moore and S. Derry Single dose oral flurbiprofen for acute postoperative pain in adults Cochrane Libr. (2009); DOI: 10.1002/14651858.CD007358.

  • 7. M. Takada M. Fukusaki Y. Terao K. Yamashita C. Inadomi M. Takada and K. Sumikawa Preadministration of flurbiprofen suppresses prostaglandin production and postoperative pain in orthopedic patients undergoing tourniquet inflation J. Clin. Anesth. 19 (2007) 97–100; DOI: 10.1016/j.jclinane.2006.05.028.

  • 8. R. K. Flath M. L. Hicks R. A. Dionne and G. B. Pelleu Jr. Pain suppression after pulpectomy with preoperative flurbiprofen J. Endodont. 13 (1987) 339–347; DOI: 10.1016/S0099-2399(87)80116-487.

  • 9. Y. Fujii and Y. Shiga Flurbiprofen axetil preceded by venous occlusion in the prevention of pain on propofol injection in the hand: a prospective randomized double-blind vehicle-controlled dose-finding study in Japanese adult surgical patients Clin. Ther. 27 (2005) 588–593; 10.1016/j.clinthera.2005.05.003.

  • 10. P.-L. Lin S.-Z. Fan C.-H. Huang H.-H. Huang M.-C. Tsai C.-J. Lin and W.-Z. Sun Analgesic effect of lidocaine patch 5 % in the treatment of acute herpes zoster: a double-blind and vehicle-controlled study Region. Anesth. Pain M. 33 (2008) 320–325.

  • 11. L. Perioli V. Ambrogi S. Giovagnoli M. Ricci P. Blasi and C. Rossi Mucoadhesive bilayered tablets for buccal sustained release of flurbiprofen AAPS PharmSciTech. 8 (2007) E20-E27; DOI: 10.1208/pt0803054.

  • 12. H. Okamoto H. Taguchi K. Iida and K. Danjo Development of polymer film dosage forms of lidocaine for buccal administration: I. Penetration rate and release rate J. Control. Release 77 (2001) 253–260; DOI: 10.1016/s0168-3659(01)00509-001.

  • 13. Y. Sudhakar K. Kuotsu and A. Bandyopadhyay Buccal bioadhesive drug delivery—a promising option for orally less efficient drugs J. Control. Release 114 (2006) 15–40; 10.1016/j.jconrel.2006.04.012.

  • 14. V. F. Patel F. Liu and M. B. Brown Advances in oral transmucosal drug delivery J. Control. Release 153 (2011) 106–116; DOI: 10.1016/j.jconrel.2011.01.027.

  • 15. A. Bernkop-Schnürch and S. Steininger Synthesis and characterisation of mucoadhesive thiolated polymers Int. J. Pharm. 194 (2000) 239–247; 10.1016/s0378-5173(99)00387-799.

  • 16. I. Knight The development and applications of sucralose a new high-intensity sweetener Can. J. Physiol. Pharmacol. 72 (1994) 435–439; DOI: 10.1139/y94-063.

  • 17. L. Allen Featured excipient: capsule and tablet diluents Int. J. Pharm. Compd. 4 (2000) 306–312.

  • 18. V. M. Patel B. G. Prajapati H. V. Patel and K. M. Patel Mucoadhesive bilayer tablets of propranolol hydrochloride AAPS PharmSciTech. 8 (2007) E203-E208; 10.1208/pt0803077.

  • 19. L. Perioli V. Ambrogi D. Rubini S. Giovagnoli M. Ricci P. Blasi and C. Rossi Novel mucoadhesive buccal formulation containing metronidazole for the treatment of periodontal disease J. Control. Release 95 (2004) 521–533; DOI: 10.1016/j.jconrel.2003.12.018.

  • 20. S. Mohammadi-Samani R. Bahri-Najafi and G. Yousefi Formulation and in vitro evaluation of prednisolone buccoadhesive tablets Farmaco 60 (2005) 339–344; DOI: 10.1016/j.farmac.2005.01.009.

  • 21. S. Edavalath and B. Rao Design development and optimization of buccal bioadhesive tablets of diclofenac sodium for the treatment of odontalgia Ars Pharm. 52 (2011) 5–13.

  • 22. M. S. Pendekal Ars Pharm P. K. Tegginamat Formulation and evaluation of a bioadhesive patch for buccal delivery of tizanidine Acta Pharm. Sin. B 2 (2012) 318–324; DOI: 10.1016/j.apsb.2011.12.012.

  • 23. N. Shah G. Zhang V. Apelian F. Zeng M. H. Infeld and A. W. Malick Prediction of drug release from hydroxypropyl methylcellulose (HPMC) matrices: effect of polymer concentration Pharm. Res. 10 (1993) 1693–1695; DOI: 10.1023/a:1018901509855.

  • 24. J. Malakar A. K. Nayak and S. Goswami Use of response surface methodology in the formulation and optimization of bisoprolol fumarate matrix tablets for sustained drug release ISRN Pharmaceutics 2012 (2012) article ID 730624; DOI: 10.5402/2012/730624.

  • 25. S. Dash P. N. Murthy L. Nath and P. Chowdhury Kinetic modeling on drug release from controlled drug delivery systems Acta Pol. Pharm. 67 (2010) 217–223; DOI: 10.1080/10717540490265379.

  • 26. D. Jones Pharmaceutical Applications of Polymers for Drug Delivery Smithers Rapra Publishing U.K. 2004. pp. 31–35.

  • 27. J. Parojčić Z. Ðurić M. Jovanović and S. Ibrić An investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymers Drug Deliv. 11 (2004) 59–65.

  • 28. X. Huang and C. S. Brazel On the importance and mechanisms of burst release in matrix-controlled drug delivery systems J. Control. Release 73 (2001) 121–136; DOI: 10.1016/s0168-3659(01)00248-601.

Search
Journal information
Impact Factor

IMPACT FACTOR 2018: 1.405
5-year IMPACT FACTOR: 1.701

CiteScore 2018: 1.47

SCImago Journal Rank (SJR) 2018: 0.314
Source Normalized Impact per Paper (SNIP) 2018: 0.637

Cited By
Metrics
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 371 278 14
PDF Downloads 194 164 0