Analysis of TGFB1, CD105 and FSP1 expression in human granulosa cells during a 7-day primary in vitro culture
Published Online: Dec 31, 2020
Page range: 152 - 157
Received: Oct 06, 2020
Accepted: Nov 17, 2020
DOI: https://doi.org/10.2478/acb-2020-0019
Keywords
© 2020 Artur Bryja, Wojciech Pieńkowski, Katarzyna Stefańska, Błażej Chermuła, Rut Bryl, Maria Wieczorkiewicz, Jakub Kulus, Grzegorz Wąsiatycz, Dorota Bukowska, Kornel Ratajczak, Jędrzej M. Jaśkowski, James N. Petitte, Paul Mozdziak, Leszek Pawelczyk, Robert Z. Spaczyński, Paweł Antosik, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
The human granulosa cells (GCs) surround the oocyte and form the ovarian follicle’s proper architecture.
These sub-populations include mural granulosa cells, antral granulosa cells, and cumulus granulosa cells.
Their main functions are to support the oocyte’s growth (cumulus granulosa cells) and estradiol production (mural granulosa cells). After ovulation, the granulosa cells transform into the luteal cells of the corpus luteum and produce progesterone.
Our study investigated the expression profile of three genes: TGFB1, CD105, and FSP1 during a 7-day
Changes in the expression of CD105 and FSP1 could be observed during the 7-day