O artykule
Data publikacji: 13 lis 2012
Zakres stron: 115 - 130
DOI: https://doi.org/10.2478/v10127-012-0012-1
Słowa kluczowe
This content is open access.
We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of individual Fisher information matrix and describe a user-defined option of the library.