<abstract xmlns="http://www.w3.org/1999/xhtml"><p>At present, concentrations of pharmaceuticals in surface and ground waters are low; however, even low concentrations of certain substances may prove very harmful. One of such pharmaceutical drugs is diclofenac, a popular non-steroidal anti-inflammatory drug (NSAID). For this reason, it is important to determine its mobility in groundwater and to estimate parameters of migration. Authors conducted column tests for two porous media: an artificial one, consisting of glass granules, and a natural one, i.e., sandur sand obtained from a site north of the city of Poznań (Poland). During the test, impulse breakthrough curves of chloride ions and diclofenac were recorded. The results were used to identify a specific sorption model and to determine values of migration parameters. Solutions of the inverse problem using optimisation methods and of equations of mathematical migration models were carried out in a MATLAB environment. Based on test results, the mobility of diclofenac is shown to be very high and comparable to that of chloride ions. The tests also revealed a slight and irreversible sorption of diclofenac on grains of both porous media.</p></abstract>

At present, concentrations of pharmaceuticals in surface and ground waters are low; however, even low concentrations of certain substances may prove very harmful. One of such pharmaceutical drugs is diclofenac, a popular non-steroidal anti-inflammatory drug (NSAID). For this reason, it is important to determine its mobility in groundwater and to estimate parameters of migration. Authors conducted column tests for two porous media: an artificial one, consisting of glass granules, and a natural one, i.e., sandur sand obtained from a site north of the city of Poznań (Poland). During the test, impulse breakthrough curves of chloride ions and diclofenac were recorded. The results were used to identify a specific sorption model and to determine values of migration parameters. Solutions of the inverse problem using optimisation methods and of equations of mathematical migration models were carried out in a MATLAB environment. Based on test results, the mobility of diclofenac is shown to be very high and comparable to that of chloride ions. The tests also revealed a slight and irreversible sorption of diclofenac on grains of both porous media.

Laboratory investigations of diclofenac migration in saturated porous media – a case study

Institute of Physical Geography and Environmental Planning

Institute of Chemistry and Technical Electrochemistry

Institute of Mechanical Engineering of the Environment and Applied Information Technology

Geologos

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

At present, concentrations of pharmaceuticals in surface and ground waters are low; however, even low concentrations of certain substances may prove very...

Laboratory investigations of diclofenac migration in saturated porous media – a case study

Data publikacji: 31 gru 2019

Zakres stron: 213 - 223

Otrzymano: 01 kwi 2019

Przyjęty: 22 lip 2019

DOI: https://doi.org/10.2478/logos-2019-0023

Słowa kluczowe
non-steroidal anti-inflammatory drug, column test, parameter estimation, optimisation method, MATLAB

© 2019 Monika Okońska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Laboratory investigations of diclofenac migration in saturated porous media – a case study

Data publikacji: 31 gru 2019

Zakres stron: 213 - 223

Otrzymano: 01 kwi 2019

Przyjęty: 22 lip 2019

DOI: https://doi.org/10.2478/logos-2019-0023

Słowa kluczowenon-steroidal anti-inflammatory drug, column test, parameter estimation, optimisation method, MATLAB

© 2019 Monika Okońska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
non-steroidal anti-inflammatory drug, column test, parameter estimation, optimisation method, MATLAB