Initial Fluid Resuscitation Following Adjusted Body Weight Dosing in Sepsis and Septic Shock
, , , oraz | 27 lis 2019
O artykule
Article Category: Research Article
Data publikacji: 27 lis 2019
Zakres stron: 130 - 135
Otrzymano: 01 cze 2019
Przyjęty: 28 paź 2019
DOI: https://doi.org/10.2478/jccm-2019-0025
Słowa kluczowe
© 2019 Oana Antal, Elena Ștefănescu, Monica Mleșnițe, Andrei Mihai Bălan, Natalia Hagău, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
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The haemodynamic parameters of the patients included in the study
| N=71 patients | Time of presentation | Study inclusion (time 0) | p value* | 3rd hour | p value** |
|---|---|---|---|---|---|
| Heart rate b/min (SD) | # | 103.92 (18.67) | - | 98.7 (18.8) | 0.10 |
| Systolic blood pressure mm Hg (SD) | 98 (22.5) | 118.0 (21.07) | <0.0001 | 122.7 (18.1) | 0.15 |
| Diastolic blood pressure mm Hg (SD) | 49.5 (13.6) | 56.64 (13.13) | 0.0003 | 55.5 (11.8) | 0.60 |
| Mean arterial blood pressure mm Hg (SD) | 64.6 (15) | 75.22 (13.69) | <0.0001 | 74.8 (11.6) | 0.86 |
| Central venous pressure mm Hg (SD) | # | 7.34 (4.64) | - | 8.5 (4.7) | 0.13 |
| CI l/min Mean (SD) | # | # | - | 3.5 (0.7) | - |
| SVI Mean (SD) ml/m2/beat ) | # | # | - | 35.78 (10.7) | - |
| SVRI Mean (SD) dynes-sec/cm–5/m2 | # | # | - | 1691.6 (630.06) | - |
| GEDI Mean (SD) ml/kg | # | # | - | 647.5 (166.7) | - |
| ITBI Mean (SD) ml/m2 | # | # | - | 829.7 (233.1) | - |
| ELWI Mean (SD) Mean (SD) ml/kg | # | # | - | 8.75 (3.76) | - |
| Norepinephrine mcg/kg/min | 0.07 (0.1) | 0.12 (0.15) | 0.01 | 0.11 (0.14) | 0.49 |
| VDI | 0.11 (0.1) | 0.12 (0.15) | 0.03 | 0.16 (0.21) | 0.54 |
| Creatinine mean (SD) μmol/l | # | 218.34 (192.7) | - | # | - |
| Ureea mean (SD) mmol/l | # | 16.2 (12.1) | - | # | - |
| lactate (septic shock patients) mmol/l (SD) | # | 3.93 (2.53) | - | 3.80 (3.03) | 0.30 |
| oliguria/anuria no of patients (%) | # | 40 (56.3) | - | 28 (39.43) | 0.04 |
| Capilary refill time >3 sec no of patients (%) | # | 17 (23.94)) | - | 12 (16.9) | 0.29 |
The demographic and physiologic characteristics of the patients enrolled
| Diagnosis | N (%) |
|---|---|
| Sepsis | 37 (52.1%) |
| Septic shock | 34 (47.9%) |
| Type of sepsis | N (%) |
| Medical | 26 (36.6%) |
| Surgical | 45 (63.4%) |
| Sex | N (%) |
| Female | 21 (29.6%) |
| Male | 50 (70.4%) |
| Age Mean (SD) | 62.68 (14.78) |
| Weight kg Mean (SD) | 82.58 (20.03) |
| Body Surface Area Mean (SD) | 1.92 (0.24) |
| Ventilation | N (%) |
| Mechanically ventilated | 49 (69%) |
| Spontaneous ventilation | 22 (31%) |
| PEEP for Mechanically ventilated at study incluion (time 0) Mean (SD) | 5.69 (1.1) |
| SOFA Score at study inclusion (time 0) Mean (SD) | 9.58 (3.27) |
| Cardiovascular SOFA at study incluion (time 0) Mean (SD) | 2.85 (1.4) |
| APACHE II Score at study incluion (time 0) Mean (SD) | 21.94 (8.64) |
| Heart Rate at study incluion (time 0) Mean (SD) beats/min | 105.01 (20.64) |
| Mean arterial blood pressure (MAP) at presentation Mean (SD) mm Hg | 64.6 (15.0) |
| Lactate at study inclusion (time zero) mmol/l | 22.74 (20.25) |